PMID- 38028989
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231201
IS  - 1178-7007 (Print)
IS  - 1178-7007 (Electronic)
IS  - 1178-7007 (Linking)
VI  - 16
DP  - 2023
TI  - Can Antidiabetic Medications Affect Telomere Length in Patients with Type 2 
      Diabetes? A Mini-Review.
PG  - 3739-3750
LID - 10.2147/DMSO.S428560 [doi]
AB  - The fight against aging is an eternal pursuit of humankind. The aging rate of 
      patients with type 2 diabetes mellitus (T2DM) is higher than that of healthy 
      individuals. Reducing the aging rate of patients with T2DM and extending their 
      life expectancy are challenges that endocrinologists are eager to overcome. Many 
      studies have shown that antidiabetic medications have potent anti-aging 
      potential. Telomeres are repetitive DNA sequences located at the ends of 
      chromosomes, and telomere shortening is a hallmark of aging. This review 
      summarizes clinical trials that have explored the association between 
      antidiabetic medications and telomere length (TL) in patients with T2DM and 
      explore the mystery of delaying aging in patients with T2DM from the perspective 
      of telomeres. Various antidiabetic medications may have different effects on TL 
      in patients with T2DM. Metformin and sitagliptin may protect telomeres in 
      patients with T2DM, while exogenous insulin may promote telomere shortening in 
      patients with T2DM. The effect of acarbose and glyburide on TL in patients with 
      T2DM is still uncertain due to the absence of evidence from longitudinal studies.
CI  - (c) 2023 Qin.
FAU - Qin, Baoding
AU  - Qin B
AUID- ORCID: 0009-0003-5518-6156
AD  - Department of Endocrinology, the Third Affiliated Hospital of Sun Yat-sen 
      University, Guangzhou, Guangdong, People's Republic of China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20231122
PL  - New Zealand
TA  - Diabetes Metab Syndr Obes
JT  - Diabetes, metabolic syndrome and obesity : targets and therapy
JID - 101515585
PMC - PMC10676684
OTO - NOTNLM
OT  - aging
OT  - antidiabetic medications
OT  - telomere length
OT  - type 2 diabetes
COIS- The author reports no conflicts of interest in this work.
EDAT- 2023/11/29 18:43
MHDA- 2023/11/29 18:44
PMCR- 2023/11/22
CRDT- 2023/11/29 17:20
PHST- 2023/07/02 00:00 [received]
PHST- 2023/10/07 00:00 [accepted]
PHST- 2023/11/29 18:44 [medline]
PHST- 2023/11/29 18:43 [pubmed]
PHST- 2023/11/29 17:20 [entrez]
PHST- 2023/11/22 00:00 [pmc-release]
AID - 428560 [pii]
AID - 10.2147/DMSO.S428560 [doi]
PST - epublish
SO  - Diabetes Metab Syndr Obes. 2023 Nov 22;16:3739-3750. doi: 10.2147/DMSO.S428560. 
      eCollection 2023.