PMID- 38029397
OWN - NLM
STAT- Publisher
LR  - 20240215
IS  - 2152-5250 (Print)
IS  - 2152-5250 (Linking)
DP  - 2023 Nov 15
TI  - Type-2 Diabetes Alters Hippocampal Neural Oscillations and Disrupts Synchrony 
      between the Hippocampus and Cortex.
LID - 10.14336/AD.2023.1106 [doi]
AB  - Type 2 diabetes mellitus (T2DM) increases the risk of neurological diseases, yet 
      how brain oscillations change as age and T2DM interact is not well characterized. 
      To delineate the age and diabetic effect on neurophysiology, we recorded local 
      field potentials with multichannel electrodes spanning the somatosensory cortex 
      and hippocampus (HPC) under urethane anesthesia in diabetic and normoglycemic 
      control mice, at 200 and 400 days of age. We analyzed the signal power of brain 
      oscillations, brain state, sharp wave associate ripples (SPW-Rs), and functional 
      connectivity between the cortex and HPC. We found that while both age and T2DM 
      were correlated with a breakdown in long-range functional connectivity and 
      reduced neurogenesis in the dentate gyrus and subventricular zone, T2DM further 
      slowed brain oscillations and reduced theta-gamma coupling. Age and T2DM also 
      prolonged the duration of SPW-Rs and increased gamma power during SPW-R phase. 
      Our results have identified potential electrophysiological substrates of 
      hippocampal changes associated with T2DM and age. The perturbed brain oscillation 
      features and diminished neurogenesis may underlie T2DM-accelerated cognitive 
      impairment.
FAU - Rabiller, Gratianne
AU  - Rabiller G
AD  - Department of Neurological Surgery, University of California at San Francisco, 
      San Francisco, CA, USA.
AD  - San Francisco VA medical Center, San Francisco, CA, USA.
FAU - Ip, Zachary
AU  - Ip Z
AD  - Departments of Bioengineering, University of Washington, Seattle, WA, USA.
FAU - Zarrabian, Shahram
AU  - Zarrabian S
AD  - Department of Neurological Surgery, University of California at San Francisco, 
      San Francisco, CA, USA.
AD  - San Francisco VA medical Center, San Francisco, CA, USA.
FAU - Zhang, Hongxia
AU  - Zhang H
AD  - Department of Neurological Surgery, University of California at San Francisco, 
      San Francisco, CA, USA.
AD  - San Francisco VA medical Center, San Francisco, CA, USA.
FAU - Sato, Yoshimichi
AU  - Sato Y
AD  - Department of Neurological Surgery, University of California at San Francisco, 
      San Francisco, CA, USA.
AD  - San Francisco VA medical Center, San Francisco, CA, USA.
AD  - Department of Neurosurgery, Tohoku University Graduate School of Medicine, 
      Sendai, Japan.
FAU - Yazdan-Shahmorad, Azadeh
AU  - Yazdan-Shahmorad A
AD  - Departments of Bioengineering, University of Washington, Seattle, WA, USA.
AD  - Electrical and Computer Engineering, University of Washington, Seattle, WA, USA.
FAU - Liu, Jialing
AU  - Liu J
AD  - Department of Neurological Surgery, University of California at San Francisco, 
      San Francisco, CA, USA.
AD  - San Francisco VA medical Center, San Francisco, CA, USA.
LA  - eng
GR  - IK6 BX004600/BX/BLRD VA/United States
GR  - I01 BX003335/BX/BLRD VA/United States
GR  - IS1 BX005033/BX/BLRD VA/United States
GR  - R21 NS120193/NS/NINDS NIH HHS/United States
GR  - R01 NS102886/NS/NINDS NIH HHS/United States
PT  - Journal Article
DEP - 20231115
PL  - United States
TA  - Aging Dis
JT  - Aging and disease
JID - 101540533
UOF - bioRxiv. 2023 May 26;:. PMID: 37292743
EDAT- 2023/11/29 18:42
MHDA- 2023/11/29 18:42
CRDT- 2023/11/29 17:31
PHST- 2023/09/06 00:00 [received]
PHST- 2023/11/06 00:00 [accepted]
PHST- 2023/11/29 18:42 [medline]
PHST- 2023/11/29 18:42 [pubmed]
PHST- 2023/11/29 17:31 [entrez]
AID - AD.2023.1106 [pii]
AID - 10.14336/AD.2023.1106 [doi]
PST - aheadofprint
SO  - Aging Dis. 2023 Nov 15. doi: 10.14336/AD.2023.1106.