PMID- 38029399
OWN - NLM
STAT- Publisher
LR  - 20231129
IS  - 2152-5250 (Print)
IS  - 2152-5250 (Linking)
DP  - 2023 Nov 21
TI  - Multi-Trajectories of Intrinsic Capacity Decline and Their Impact on Age-Related 
      Outcomes: A 20-Year National Longitudinal Cohort Study.
LID - 10.14336/AD.2023.1115-1 [doi]
AB  - The existence of intrinsic capacity (IC) subtypes and their distinct impacts on 
      age-related outcomes remain unexplored. This study sought to investigate IC 
      impairment trajectories across domains and their associations with the risk of 
      age-related outcomes, including falls, functional limitations, reduced quality of 
      life (QoL) and mortality at 4- and 8-year follow-ups. The study sample comprised 
      1,782 older adults residing in the community from the Taiwan Longitudinal Study 
      on Ageing (TLSA). Utilizing group-based multitrajectory modeling, distinct 
      subtypes of IC decline trajectories across various domains were identified. Cox 
      proportional hazard models and multivariable logistic regression analyses were 
      employed to assess the associations between the identified subtypes and 
      age-related outcomes. We identified four subtypes of IC decline: robust with mild 
      decline (n=902), hearing loss with cognitive decline (n=197), physio-cognitive 
      decline (PCD) with depression (n=373), and severe IC decline (n=310). Over the 
      4-year study period, compared to the robust with mild decline group, hearing loss 
      with cognitive decline group exhibited a significantly higher risk of diminished 
      QoL (OR=2.53 [1.66-3.86], p>0.01), whereas those in the PCD with depression group 
      experienced an elevated risk of falls (OR=1.62 [1.18-2.23], p>0.01), as well as 
      functional limitation (OR=2.61 [1.81-3.75], p>.01). Individuals in the severe IC 
      decline group faced a substantially increased risk of all outcomes of interest. 
      Distinct subtypes of IC decline across different domains have varying impacts on 
      age-related outcomes, highlighting the need for a personalized approach to 
      promote healthy ageing at the population level, while further investigation into 
      specific pathophysiological mechanisms is warranted as well.
FAU - Meng, Lin-Chieh
AU  - Meng LC
AD  - Graduate Institute of Clinical Pharmacy, College of Medicine, National Taiwan 
      University, Taipei, Taiwan.
FAU - Chuang, Hui-Min
AU  - Chuang HM
AD  - Graduate Institute of Clinical Pharmacy, College of Medicine, National Taiwan 
      University, Taipei, Taiwan.
FAU - Lu, Wan-Hsuan
AU  - Lu WH
AD  - Gerontopole of Toulouse, Institute of Ageing, Toulouse University Hospital (CHU 
      Toulouse), Toulouse, France.
AD  - Maintain Aging Research Team, CERPOP, Inserm, Universite Paul Sabatier, Toulouse, 
      France.
FAU - Lee, Wei-Ju
AU  - Lee WJ
AD  - Center for Healthy Longevity and Aging Sciences, National Yang Ming Chiao Tung 
      University, Taipei, Taiwan.
AD  - Center for Geriatrics and Gerontology, Taipei Veterans General Hospital, Taipei, 
      Taiwan.
AD  - Department of Family Medicine, Taipei Veterans General Hospital Yuanshan Branch, 
      Yi-Lan County, Taiwan.
FAU - Liang, Chih-Kuang
AU  - Liang CK
AD  - Center for Healthy Longevity and Aging Sciences, National Yang Ming Chiao Tung 
      University, Taipei, Taiwan.
AD  - Center for Geriatrics and Gerontology, Kaohsiung Veterans General Hospital, 
      Kaohsiung City, Taiwan.
FAU - Loh, Ching-Hui
AU  - Loh CH
AD  - Center for Healthy Longevity and Aging Sciences, National Yang Ming Chiao Tung 
      University, Taipei, Taiwan.
AD  - Center for Healthy Longevity, Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical 
      Foundation, Hualien County, Taiwan.
FAU - Hsiao, Fei-Yuan
AU  - Hsiao FY
AD  - Graduate Institute of Clinical Pharmacy, College of Medicine, National Taiwan 
      University, Taipei, Taiwan.
AD  - School of Pharmacy, College of Medicine, National Taiwan University, Taipei, 
      Taiwan.
AD  - Department of Pharmacy, National Taiwan University Hospital, Taipei, Taiwan.
FAU - Chen, Liang-Kung
AU  - Chen LK
AD  - Taipei Municipal Gan-Dau Hospital (Managed by Taipei Veterans General Hospital), 
      Taipei, Taiwan.
AD  - Center for Healthy Longevity and Aging Sciences, National Yang Ming Chiao Tung 
      University, Taipei, Taiwan.
AD  - Center for Geriatrics and Gerontology, Taipei Veterans General Hospital, Taipei, 
      Taiwan.
LA  - eng
PT  - Journal Article
DEP - 20231121
PL  - United States
TA  - Aging Dis
JT  - Aging and disease
JID - 101540533
EDAT- 2023/11/29 18:42
MHDA- 2023/11/29 18:42
CRDT- 2023/11/29 17:31
PHST- 2023/08/08 00:00 [received]
PHST- 2023/11/15 00:00 [accepted]
PHST- 2023/11/29 18:42 [medline]
PHST- 2023/11/29 18:42 [pubmed]
PHST- 2023/11/29 17:31 [entrez]
AID - AD.2023.1115-1 [pii]
AID - 10.14336/AD.2023.1115-1 [doi]
PST - aheadofprint
SO  - Aging Dis. 2023 Nov 21. doi: 10.14336/AD.2023.1115-1.