PMID- 38029886
OWN - NLM
STAT- MEDLINE
DCOM- 20240122
LR  - 20240201
IS  - 1098-8823 (Print)
IS  - 1098-8823 (Linking)
VI  - 170
DP  - 2024 Feb
TI  - Moringa oleifera leaves extract loaded gold nanoparticles offers a promising 
      approach in protecting against experimental nephrotoxicity.
PG  - 106800
LID - S1098-8823(23)00097-7 [pii]
LID - 10.1016/j.prostaglandins.2023.106800 [doi]
AB  - Cisplatin is one of the most important antitumor drugs, however; it has numerous 
      adverse effects like nephrotoxicity which is considered one of cisplatin uses . 
      The study was planned to evaluate the nephroprotective effect of M. oleifera 
      leaves extract loaded gold nanoparticles (Au-NPs) against cisplatin-induced 
      nephrotoxicity in rats. Initially, total phenolic contents (TPC) and the 
      antioxidant activity of the M. oleifera leaves extract were evaluated and 
      recorded 8.50 mg/g and 39.89 % respectively. After that, the dry leaves of M. 
      oleifera were grinded into fine powder and extracted using water extraction 
      system. Then, different volumes (0.5, 1 and 2 mL) of M. Oleifera were blended 
      with constant volume of Au-NPs (1 mL). Both Au-NPs and M. oleifera extract loaded 
      Au-NPs were investigated using transmission electron microscope (TEM) that 
      illustrated the deposition of M. Oleifera onto Au-NPs. The experimental study was 
      performed on seventy male albino rats alienated into seven groups. Group I 
      healthy rats, group II injected with one dose of cisplatin (CisPt), groups from 
      III to VII treated groups received CisPt then received M. Oleifera leaves extract 
      alone and /or Au-NPs with different ratios and concentrations. After the 
      experiment' time, serum urea and creatinine, kidney injury molecule-1 
      (KIM-1), advanced oxidation protein products (AOPP), monocyte chemoattractant 
      protein-1 (MCP-1), tumor necrotic factor-alpha (TNF-alpha), and interleukin-6 (IL-6) were 
      evaluated as markers of renal nephrotoxicity. The kidneys of rats were excised 
      for malondialdehyde (MDA), nitric oxide (NO), and superoxide dismutase (SOD) 
      assessments. Induction of CisPt showed a highly significant disturbance in 
      oxidant/anti-oxidant balance and inducing inflammatory cascades supporting 
      nephrotoxicity, while treatment with M. Oleifera leaves extract, Au-NPs, and the 
      different concentrations of the extract loaded on Au-NPs had a crucial role in 
      attenuating oxidative stress, enhancing antioxidant systems, and reducing 
      inflammatory biomarkers, although the most significant results showed a powerful 
      scavenging activity against nephrotoxicity induced by CisPt was obtained with M. 
      Oleifera leaves extract loaded on Au-NPs with a concentration of 2:1 
      respectively.
CI  - Copyright (c) 2023 Elsevier Inc. All rights reserved.
FAU - Hussein, Jihan
AU  - Hussein J
AD  - Medical Biochemistry Department, National Research Centre, Dokki 12622, Egypt. 
      Electronic address: jihan_husein@yahoo.com.
FAU - El-Bana, Mona
AU  - El-Bana M
AD  - Medical Biochemistry Department, National Research Centre, Dokki 12622, Egypt.
FAU - Abdel-Latif, Yasmin
AU  - Abdel-Latif Y
AD  - Medical Biochemistry Department, National Research Centre, Dokki 12622, Egypt; 
      Faculty of Biotechnology, October University for Modern Sciences and Arts, Giza, 
      Egypt.
FAU - El-Sayed, Samah
AU  - El-Sayed S
AD  - Dairy Science Department, National Research Centre, Dokki 12622, Egypt.
FAU - Shaarawy, Sahar
AU  - Shaarawy S
AD  - Pre-Treatment and Finishing of Cellulosic Fabric Department, National Research 
      Centre, Dokki 12622, Egypt.
FAU - Medhat, Dalia
AU  - Medhat D
AD  - Medical Biochemistry Department, National Research Centre, Dokki 12622, Egypt.
LA  - eng
PT  - Journal Article
DEP - 20231127
PL  - United States
TA  - Prostaglandins Other Lipid Mediat
JT  - Prostaglandins & other lipid mediators
JID - 9808648
RN  - 7440-57-5 (Gold)
RN  - Q20Q21Q62J (Cisplatin)
RN  - 0 (Plant Extracts)
RN  - 0 (Antioxidants)
SB  - IM
MH  - Rats
MH  - Male
MH  - Animals
MH  - *Moringa oleifera/metabolism
MH  - Gold/pharmacology
MH  - Cisplatin/pharmacology
MH  - Plant Extracts/pharmacology
MH  - *Metal Nanoparticles
MH  - Antioxidants/metabolism
MH  - Oxidative Stress
OTO - NOTNLM
OT  - Cisplatin
OT  - Gold nanoparticle
OT  - Kidney injury molecule-1
OT  - Monocyte chemoattractant protein-1
OT  - Moringa oleifera leaves
COIS- Conflict of interest The authors declare that there is no conflict of interest.
EDAT- 2023/11/30 00:42
MHDA- 2024/01/22 06:42
CRDT- 2023/11/29 19:26
PHST- 2023/09/13 00:00 [received]
PHST- 2023/11/02 00:00 [revised]
PHST- 2023/11/15 00:00 [accepted]
PHST- 2024/01/22 06:42 [medline]
PHST- 2023/11/30 00:42 [pubmed]
PHST- 2023/11/29 19:26 [entrez]
AID - S1098-8823(23)00097-7 [pii]
AID - 10.1016/j.prostaglandins.2023.106800 [doi]
PST - ppublish
SO  - Prostaglandins Other Lipid Mediat. 2024 Feb;170:106800. doi: 
      10.1016/j.prostaglandins.2023.106800. Epub 2023 Nov 27.