PMID- 38030790
OWN - NLM
STAT- MEDLINE
DCOM- 20240131
LR  - 20240412
IS  - 1476-5594 (Electronic)
IS  - 0950-9232 (Linking)
VI  - 43
IP  - 5
DP  - 2024 Jan
TI  - Functional evaluation of dendritic cells and extracellular vesicles as 
      immunotherapy for breast cancer.
PG  - 319-327
LID - 10.1038/s41388-023-02893-2 [doi]
AB  - Dendritic cells (DCs) play critical roles in recognizing and presenting antigens 
      to T cells. They secrete dendritic cell-derived extracellular vesicles (DC-sEVs), 
      which could mimic the function of DCs. Therefore, we explore the possibility of 
      using DC-sEVs as a potential personalized vaccine in this study. We compared the 
      efficacy of DCs and DC-sEVs on stimulating the immune system to target breast 
      cancer cells and found that DC-sEVs had significantly more MHC molecules on the 
      surface when compared to the parental DCs. In our in vivo and in vitro testing, 
      Dc-sEVs showed significant advantages over DCs, regarding efficacy, safety, 
      storage, and potential delivery advantages. DC-sEVs were able to suppress the 
      growth of immune-cold breast tumors, while DCs failed to do so. These results 
      indicate the strong potential utility of DC-sEVs as a personalized immunotherapy 
      for breast cancer.
CI  - (c) 2023. This is a U.S. Government work and not under copyright protection in the 
      US; foreign copyright protection may apply.
FAU - Lyu, Feng
AU  - Lyu F
AD  - Department of Cancer Biology, Wake Forest University School of Medicine, 
      Winston-Salem, NC, 27157, USA.
AD  - Department of Breast Surgery, Henan Provincial People's Hospital, People's 
      Hospital of Zhengzhou University; People's Hospital of Henan University, 450003, 
      Zhengzhou, Henan, China.
FAU - Wu, Kerui
AU  - Wu K
AD  - Department of Cancer Biology, Wake Forest University School of Medicine, 
      Winston-Salem, NC, 27157, USA.
AD  - Department of Nanoscience, The Joint School of Nanoscience and Nanoengineering, 
      University of North Carolina Greensboro, Greensboro, NC, 27401, USA.
FAU - Wu, Shih-Ying
AU  - Wu SY
AD  - Department of Cancer Biology, Wake Forest University School of Medicine, 
      Winston-Salem, NC, 27157, USA.
FAU - Deshpande, Ravindra Pramod
AU  - Deshpande RP
AD  - Department of Cancer Biology, Wake Forest University School of Medicine, 
      Winston-Salem, NC, 27157, USA.
FAU - Tyagi, Abhishek
AU  - Tyagi A
AUID- ORCID: 0000-0002-0155-2099
AD  - Department of Cancer Biology, Wake Forest University School of Medicine, 
      Winston-Salem, NC, 27157, USA.
FAU - Ruiz, Isabella
AU  - Ruiz I
AD  - Department of Cancer Biology, Wake Forest University School of Medicine, 
      Winston-Salem, NC, 27157, USA.
FAU - Yalavarthi, Sindhu
AU  - Yalavarthi S
AD  - Department of Nanoscience, The Joint School of Nanoscience and Nanoengineering, 
      University of North Carolina Greensboro, Greensboro, NC, 27401, USA.
FAU - Watabe, Kounosuke
AU  - Watabe K
AUID- ORCID: 0000-0001-7441-6322
AD  - Department of Cancer Biology, Wake Forest University School of Medicine, 
      Winston-Salem, NC, 27157, USA. kwatabe@wakehealth.edu.
LA  - eng
GR  - R01 CA205067/CA/NCI NIH HHS/United States
PT  - Journal Article
DEP - 20231129
PL  - England
TA  - Oncogene
JT  - Oncogene
JID - 8711562
SB  - IM
MH  - Humans
MH  - Female
MH  - *Breast Neoplasms/therapy
MH  - Dendritic Cells
MH  - T-Lymphocytes
MH  - Immunotherapy/methods
MH  - *Extracellular Vesicles
EDAT- 2023/11/30 00:43
MHDA- 2024/01/31 06:42
CRDT- 2023/11/29 23:33
PHST- 2023/06/06 00:00 [received]
PHST- 2023/11/10 00:00 [accepted]
PHST- 2023/11/06 00:00 [revised]
PHST- 2024/01/31 06:42 [medline]
PHST- 2023/11/30 00:43 [pubmed]
PHST- 2023/11/29 23:33 [entrez]
AID - 10.1038/s41388-023-02893-2 [pii]
AID - 10.1038/s41388-023-02893-2 [doi]
PST - ppublish
SO  - Oncogene. 2024 Jan;43(5):319-327. doi: 10.1038/s41388-023-02893-2. Epub 2023 Nov 
      29.