PMID- 38032018
OWN - NLM
STAT- MEDLINE
DCOM- 20240123
LR  - 20240202
IS  - 1939-1676 (Electronic)
IS  - 0891-6640 (Print)
IS  - 0891-6640 (Linking)
VI  - 38
IP  - 1
DP  - 2024 Jan-Feb
TI  - Thyroid function tests during nonthyroidal illness syndrome and recovery in 
      acutely ill dogs.
PG  - 111-122
LID - 10.1111/jvim.16947 [doi]
AB  - BACKGROUND: Nonthyroidal illness syndrome (NTIS) can result in thyroid function 
      test alterations that mimic hypothyroidism. The duration of NTIS-induced changes 
      in dogs is not well-described. OBJECTIVES: Document alterations in thyroid 
      function tests during NTIS and recovery, and the time necessary for their 
      resolution. ANIMALS: From 103 dogs sampled, 25 euthyroid dogs with acute, 
      resolvable illness having a low serum total thyroxine (TT4) concentration on 
      admission were analyzed. METHODS: Prospective observational study. Serum TT4 
      concentration was measured in 103 dogs within 4 hours of admission. If below the 
      reference interval (RI), subsequent serum samples were obtained every 24 hours 
      from admission until discharge (acute phase) and at 2 weeks and 4 weeks after 
      discharge (recovery phase). Serum samples were submitted for batch measurement of 
      serum TT4, free thyroxine (fT4), total 3,5,3'-triiodothyronine (TT3), and 
      thyroid-stimulating hormone (TSH) concentrations. RESULTS: In the cohort of dogs 
      analyzed, serum TT4, TT3, and fT4 concentrations were below the RI in 100%, 80%, 
      and 16% at admission; 20%, 80%, and 0% at discharge; 4%, 8%, and 0% at 2 weeks; 
      and 0%, 0%, and 0% at 4 weeks, respectively. Serum TSH concentration was within 
      the RI in 100% at admission and discharge, and above the RI in 4% and 12% at 
      2 weeks and 4 weeks, respectively. CONCLUSIONS AND CLINICAL IMPORTANCE: Naturally 
      occurring NTIS in dogs induces alterations in thyroid function tests during acute 
      illness and recovery. Measurement of serum TT4 concentration 2 to 4 weeks after 
      discharge or serum fT4 concentration by ED during illness is recommended for 
      accurate assessment of thyroid function in acutely ill dogs.
CI  - (c) 2023 The Authors. Journal of Veterinary Internal Medicine published by Wiley 
      Periodicals LLC on behalf of American College of Veterinary Internal Medicine.
FAU - Bolton, Timothy A
AU  - Bolton TA
AUID- ORCID: 0000-0002-5970-6441
AD  - Department of Small Animal Clinical Sciences, Virginia-Maryland Regional College 
      of Veterinary Medicine, Virginia Tech University, Blacksburg, Virginia, USA.
FAU - Panciera, David L
AU  - Panciera DL
AD  - Department of Small Animal Clinical Sciences, Virginia-Maryland Regional College 
      of Veterinary Medicine, Virginia Tech University, Blacksburg, Virginia, USA.
FAU - Voudren, Caylie D
AU  - Voudren CD
AD  - Department of Small Animal Clinical Sciences, Virginia-Maryland Regional College 
      of Veterinary Medicine, Virginia Tech University, Blacksburg, Virginia, USA.
FAU - Crawford-Jennings, Matthew I
AU  - Crawford-Jennings MI
AD  - Department of Small Animal Clinical Sciences, Virginia-Maryland Regional College 
      of Veterinary Medicine, Virginia Tech University, Blacksburg, Virginia, USA.
LA  - eng
GR  - 02686-A/American Kennel Club Canine Health Foundation/
PT  - Journal Article
PT  - Observational Study, Veterinary
DEP - 20231130
PL  - United States
TA  - J Vet Intern Med
JT  - Journal of veterinary internal medicine
JID - 8708660
RN  - Q51BO43MG4 (Thyroxine)
RN  - 06LU7C9H1V (Triiodothyronine)
RN  - 0 (Thyroid Hormones)
RN  - 9002-71-5 (Thyrotropin)
SB  - IM
MH  - Humans
MH  - Dogs
MH  - Animals
MH  - *Thyroid Function Tests/veterinary
MH  - *Thyroxine
MH  - Triiodothyronine
MH  - Thyroid Hormones
MH  - Thyrotropin
PMC - PMC10800236
OTO - NOTNLM
OT  - dog
OT  - hypothyroidism
OT  - normalization
OT  - sick
COIS- Authors declare no conflict of interest.
EDAT- 2023/11/30 12:42
MHDA- 2024/01/23 06:42
PMCR- 2023/11/30
CRDT- 2023/11/30 07:13
PHST- 2023/05/01 00:00 [received]
PHST- 2023/11/13 00:00 [accepted]
PHST- 2024/01/23 06:42 [medline]
PHST- 2023/11/30 12:42 [pubmed]
PHST- 2023/11/30 07:13 [entrez]
PHST- 2023/11/30 00:00 [pmc-release]
AID - JVIM16947 [pii]
AID - 10.1111/jvim.16947 [doi]
PST - ppublish
SO  - J Vet Intern Med. 2024 Jan-Feb;38(1):111-122. doi: 10.1111/jvim.16947. Epub 2023 
      Nov 30.