PMID- 38034261
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231202
IS  - 2168-8184 (Print)
IS  - 2168-8184 (Electronic)
IS  - 2168-8184 (Linking)
VI  - 15
IP  - 10
DP  - 2023 Oct
TI  - Association Between Serum Uric Acid Levels and Oxido-Inflammatory Biomarkers With 
      Coronary Artery Disease in Type 2 Diabetic Patients.
PG  - e47913
LID - 10.7759/cureus.47913 [doi]
LID - e47913
AB  - BACKGROUND: Cardiovascular disease signifies a major cause of morbidity and 
      mortality among patients with type 2 diabetes mellitus (T2DM). Serum uric acid 
      (SUA) levels are elevated during the initial phases of impaired glucose 
      metabolism. This work was designed to explore the association between SUA levels, 
      serum oxido-inflammatory biomarkers, and the risk of coronary artery disease 
      (CAD) in T2DM patients as the primary outcome. The secondary outcome was to 
      assess the prognostic role of SUA in the prediction of the risk of CAD in T2DM 
      patients. METHODS: In this case-control study, we enrolled 110 patients with T2DM 
      who were further divided into patients with CAD and without CAD. In addition, 55 
      control participants were stringently matched to cases by age. RESULTS: Diabetic 
      patients with CAD had significantly higher serum levels of the inflammatory 
      biomarkers and the oxidative malondialdehyde but significantly lower levels of 
      serum total antioxidant capacity (TAC) compared with the controls and diabetic 
      patients without CAD. Significant positive correlations existed between SUA 
      levels and serum levels of the inflammatory biomarkers and malondialdehyde, while 
      a significant negative correlation existed between SUA levels and serum TAC. SUA 
      demonstrated an accepted discrimination ability. SUA can differentiate between 
      T2DM patients with CAD and patients without CAD, an area under the curve of 
      0.759. CONCLUSIONS: Elevated serum levels of SUA and oxido-inflammatory 
      biomarkers are associated with an increased risk of CAD in T2DM. SUA levels 
      reflect the body's inflammatory status and oxidant injury in T2DM. SUA could be 
      utilized as a simple biomarker in the prediction of CAD risk in T2DM.
CI  - Copyright (c) 2023, Gharib et al.
FAU - Gharib, Amal F
AU  - Gharib AF
AD  - Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, 
      Taif University, Taif, SAU.
FAU - Nafea, Ola E
AU  - Nafea OE
AD  - Department of Clinical Pharmacy, College of Pharmacy, Taif University, Taif, SAU.
FAU - Alrehaili, Amani A
AU  - Alrehaili AA
AD  - Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, 
      Taif University, Taif, SAU.
FAU - Almalki, Abdulraheem
AU  - Almalki A
AD  - Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, 
      Taif University, Taif, SAU.
FAU - Alharthi, Afaf
AU  - Alharthi A
AD  - Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, 
      Taif University, Taif, SAU.
FAU - Alsalmi, Ohud
AU  - Alsalmi O
AD  - Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, 
      Taif University, Taif, SAU.
FAU - Alsaeedi, Fouzeyyah A
AU  - Alsaeedi FA
AD  - Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, 
      Taif University, Taif, SAU.
FAU - Alhazmi, Ayman
AU  - Alhazmi A
AD  - Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, 
      Taif University, Taif, SAU.
FAU - Allahyani, Mamdouh
AU  - Allahyani M
AD  - Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, 
      Taif University, Taif, SAU.
FAU - Etewa, Rasha L
AU  - Etewa RL
AD  - Department of Pathology, College of Medicine, Jouf University, Sakaka, SAU.
FAU - Alsulimani, Alaa H
AU  - Alsulimani AH
AD  - Department of Laboratory, King Faisal Medical Complex (KFMC) and Research Center, 
      Taif, SAU.
FAU - Badr, Sara O
AU  - Badr SO
AD  - Department of Internal Medicine, Faculty of Medicine, Port Said University, Port 
      Said, EGY.
LA  - eng
PT  - Journal Article
DEP - 20231029
PL  - United States
TA  - Cureus
JT  - Cureus
JID - 101596737
PMC - PMC10683838
OTO - NOTNLM
OT  - coronary artery disease
OT  - inflammation
OT  - oxidative injury
OT  - type 2 diabetes mellitus
OT  - uric acid
COIS- The authors have declared that no competing interests exist.
EDAT- 2023/11/30 18:45
MHDA- 2023/11/30 18:46
PMCR- 2023/10/29
CRDT- 2023/11/30 17:31
PHST- 2023/10/27 00:00 [accepted]
PHST- 2023/11/30 18:46 [medline]
PHST- 2023/11/30 18:45 [pubmed]
PHST- 2023/11/30 17:31 [entrez]
PHST- 2023/10/29 00:00 [pmc-release]
AID - 10.7759/cureus.47913 [doi]
PST - epublish
SO  - Cureus. 2023 Oct 29;15(10):e47913. doi: 10.7759/cureus.47913. eCollection 2023 
      Oct.