PMID- 38034716
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231202
IS  - 2405-8440 (Print)
IS  - 2405-8440 (Electronic)
IS  - 2405-8440 (Linking)
VI  - 9
IP  - 11
DP  - 2023 Nov
TI  - Qi-Shen-Tang alleviates retinitis pigmentosa by inhibiting ferroptotic features 
      via the NRF2/GPX4 signaling pathway.
PG  - e22443
LID - 10.1016/j.heliyon.2023.e22443 [doi]
LID - e22443
AB  - Ferroptosis has been observed during retinal photoreceptor cell death, suggesting 
      that it plays a role in retinitis pigmentosa (RP) pathogenesis. Qi-Shen-Tang 
      (QST) is a combination of two traditional Chinese medicines used for the 
      treatment of ophthalmic diseases; however, its mechanism of action in RP and 
      ferroptosis remains unclear. Therefore, this study aimed to explore the effect 
      and potential molecular mechanisms of QST on RP. QST significantly improved 
      tissue morphology and function of the retina in the RP model mice. A significant 
      increase in retinal blood flow and normalization of the fundus structure were 
      observed in mice in the treatment group. After QST treatment, the level of iron 
      and the production of malondialdehyde decreased significantly; the levels of 
      superoxide dismutase and glutathione increased significantly; and the protein 
      expression of glutathione peroxidase 4 (GPX4), glutathione synthetase, solute 
      carrier family 7 member 11, and nuclear factor erythroid 2-related factor 2 
      (NRF2) increased significantly. The molecular docking results demonstrated 
      potential interactions between the small molecules of QST and the key proteins of 
      NRF2/GPX4 signaling pathway. Our results indicate that QST may inhibit 
      ferroptosis by inhibiting the NRF2/GPX4 signaling pathway, thereby reducing 
      RP-induced damage to retinal tissue.
CI  - (c) 2023 The Authors.
FAU - Xiong, Meng
AU  - Xiong M
AD  - Hunan Provincial Key Laboratory of Traditional Chinese Medicine Diagnostics, 
      Hunan University of Chinese Medicine, Changsha, Hunan 410208, China.
AD  - School of Traditional Chinese Medicine, Hunan University of Chinese Medicine, 
      Changsha, Hunan 410208, China.
FAU - Ou, Chen
AU  - Ou C
AD  - Hunan Provincial Key Laboratory for Prevention and Treatment of Ophthalmology and 
      Otolaryngology Diseases with Chinese Medicine, Hunan University of Chinese 
      Medicine, Changsha, Hunan 410208, China.
FAU - Yu, Chang
AU  - Yu C
AD  - Hunan Provincial Key Laboratory of Traditional Chinese Medicine Diagnostics, 
      Hunan University of Chinese Medicine, Changsha, Hunan 410208, China.
AD  - School of Traditional Chinese Medicine, Hunan University of Chinese Medicine, 
      Changsha, Hunan 410208, China.
FAU - Qiu, Jingyue
AU  - Qiu J
AD  - Hunan Provincial Key Laboratory of Traditional Chinese Medicine Diagnostics, 
      Hunan University of Chinese Medicine, Changsha, Hunan 410208, China.
AD  - School of Traditional Chinese Medicine, Hunan University of Chinese Medicine, 
      Changsha, Hunan 410208, China.
FAU - Lu, Jing
AU  - Lu J
AD  - School of Medicine, Hunan University of Chinese Medicine, Changsha, Hunan 410208, 
      China.
FAU - Fu, Chaojun
AU  - Fu C
AD  - School of Traditional Chinese Medicine, Hunan University of Chinese Medicine, 
      Changsha, Hunan 410208, China.
AD  - Hunan Provincial Key Laboratory for Prevention and Treatment of Ophthalmology and 
      Otolaryngology Diseases with Chinese Medicine, Hunan University of Chinese 
      Medicine, Changsha, Hunan 410208, China.
FAU - Peng, Qinghua
AU  - Peng Q
AD  - Hunan Provincial Key Laboratory for Prevention and Treatment of Ophthalmology and 
      Otolaryngology Diseases with Chinese Medicine, Hunan University of Chinese 
      Medicine, Changsha, Hunan 410208, China.
FAU - Zeng, Meiyan
AU  - Zeng M
AD  - School of Traditional Chinese Medicine, Hunan University of Chinese Medicine, 
      Changsha, Hunan 410208, China.
FAU - Song, Houpan
AU  - Song H
AD  - Hunan Provincial Key Laboratory of Traditional Chinese Medicine Diagnostics, 
      Hunan University of Chinese Medicine, Changsha, Hunan 410208, China.
AD  - School of Traditional Chinese Medicine, Hunan University of Chinese Medicine, 
      Changsha, Hunan 410208, China.
AD  - Hunan Provincial Key Laboratory for Prevention and Treatment of Ophthalmology and 
      Otolaryngology Diseases with Chinese Medicine, Hunan University of Chinese 
      Medicine, Changsha, Hunan 410208, China.
LA  - eng
PT  - Journal Article
DEP - 20231119
PL  - England
TA  - Heliyon
JT  - Heliyon
JID - 101672560
PMC - PMC10687062
OTO - NOTNLM
OT  - GPX4
OT  - NRF2
OT  - Qi-Shen-Tang
OT  - Retinitis pigmentosa
OT  - ferroptosis
COIS- The authors declare that they have no known competing financial interests or 
      personal relationships that could have appeared to influence the work reported in 
      this paper.
EDAT- 2023/11/30 18:45
MHDA- 2023/11/30 18:46
PMCR- 2023/11/19
CRDT- 2023/11/30 17:37
PHST- 2023/02/23 00:00 [received]
PHST- 2023/11/09 00:00 [revised]
PHST- 2023/11/13 00:00 [accepted]
PHST- 2023/11/30 18:46 [medline]
PHST- 2023/11/30 18:45 [pubmed]
PHST- 2023/11/30 17:37 [entrez]
PHST- 2023/11/19 00:00 [pmc-release]
AID - S2405-8440(23)09651-2 [pii]
AID - e22443 [pii]
AID - 10.1016/j.heliyon.2023.e22443 [doi]
PST - epublish
SO  - Heliyon. 2023 Nov 19;9(11):e22443. doi: 10.1016/j.heliyon.2023.e22443. 
      eCollection 2023 Nov.