PMID- 38036684
OWN - NLM
STAT- MEDLINE
DCOM- 20231204
LR  - 20231221
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 13
IP  - 1
DP  - 2023 Nov 30
TI  - Endoscopic gallbladder inside-stenting combined with aspirated lavage for 
      calculous cholecystitis in poor surgical candidates: a prospective pilot study.
PG  - 21156
LID - 10.1038/s41598-023-48543-1 [doi]
LID - 21156
AB  - Although long-term stent placement via endoscopic gallbladder stenting (EGBS) 
      reportedly reduces cholecystitis recurrence in patients unfit to undergo 
      cholecystectomy, it can increase the frequency of other late adverse events (AEs) 
      such as cholangitis. This study aimed to examine the feasibility of endoscopic 
      gallbladder inside-stenting (EGB-IS) with lavage and aspiration. This 
      prospective, single-center, pilot study enrolled 83 patients with acute calculous 
      cholecystitis who were poor candidates for surgery. A dedicated catheter with 
      eight side holes was used for lavage and aspiration, and a dedicated 
      single-pigtail stent equipped with a thread was used for EGB-IS. Outcomes such as 
      technical success, clinical success, early AEs, recurrence of cholecystitis, and 
      other symptomatic late AEs associated with EGB-IS with lavage and aspiration were 
      evaluated. The technical and clinical success rates were 80.7% (67/83) and 98.5% 
      (66/67), respectively. The rate of early AEs was 3.6% (3/83). The rate of 
      recurrent cholecystitis was 4.5% (3/66) and that of symptomatic late AEs (besides 
      cholecystitis) was 6.1% (4/66). Consequently, the rate of overall late AEs 
      (cholecystitis plus other events) was 10.6% (7/66). The 1-, 2-, and 3-year 
      cumulative incidence rates of all late AEs were 3.2%, 11.2%, and 18.9%, 
      respectively. EGB-IS with lavage and aspiration for calculous cholecystitis 
      showed promising results in poor surgical candidates. EGB-IS may be useful when 
      EGBS with long-term stent placement is planned, since prevention of cholecystitis 
      recurrence, without a rise in the incidence of other AEs, is anticipated.
CI  - (c) 2023. The Author(s).
FAU - Inoue, Tadahisa
AU  - Inoue T
AD  - Department of Gastroenterology, Aichi Medical University, 1-1 Yazakokarimata, 
      Nagakute, Aichi, 480-1195, Japan. tinoue-tag@umin.ac.jp.
FAU - Kitano, Rena
AU  - Kitano R
AD  - Department of Gastroenterology, Aichi Medical University, 1-1 Yazakokarimata, 
      Nagakute, Aichi, 480-1195, Japan.
FAU - Ibusuki, Mayu
AU  - Ibusuki M
AD  - Department of Gastroenterology, Aichi Medical University, 1-1 Yazakokarimata, 
      Nagakute, Aichi, 480-1195, Japan.
FAU - Kobayashi, Yuji
AU  - Kobayashi Y
AD  - Department of Gastroenterology, Aichi Medical University, 1-1 Yazakokarimata, 
      Nagakute, Aichi, 480-1195, Japan.
FAU - Ito, Kiyoaki
AU  - Ito K
AD  - Department of Gastroenterology, Aichi Medical University, 1-1 Yazakokarimata, 
      Nagakute, Aichi, 480-1195, Japan.
FAU - Yoneda, Masashi
AU  - Yoneda M
AD  - Department of Gastroenterology, Aichi Medical University, 1-1 Yazakokarimata, 
      Nagakute, Aichi, 480-1195, Japan.
LA  - eng
PT  - Journal Article
DEP - 20231130
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
SB  - IM
MH  - Humans
MH  - Gallbladder/surgery
MH  - Pilot Projects
MH  - Prospective Studies
MH  - Therapeutic Irrigation/adverse effects
MH  - Drainage/methods
MH  - *Cholecystitis/surgery/complications
MH  - *Cholecystitis, Acute/surgery
MH  - Stents/adverse effects
MH  - Retrospective Studies
MH  - Treatment Outcome
PMC - PMC10689747
COIS- The authors declare no competing interests.
EDAT- 2023/12/01 00:43
MHDA- 2023/12/04 12:41
PMCR- 2023/11/30
CRDT- 2023/11/30 23:40
PHST- 2023/08/01 00:00 [received]
PHST- 2023/11/28 00:00 [accepted]
PHST- 2023/12/04 12:41 [medline]
PHST- 2023/12/01 00:43 [pubmed]
PHST- 2023/11/30 23:40 [entrez]
PHST- 2023/11/30 00:00 [pmc-release]
AID - 10.1038/s41598-023-48543-1 [pii]
AID - 48543 [pii]
AID - 10.1038/s41598-023-48543-1 [doi]
PST - epublish
SO  - Sci Rep. 2023 Nov 30;13(1):21156. doi: 10.1038/s41598-023-48543-1.