PMID- 38037766
OWN - NLM
STAT- MEDLINE
DCOM- 20240425
LR  - 20240429
IS  - 1613-6829 (Electronic)
IS  - 1613-6810 (Linking)
VI  - 20
IP  - 17
DP  - 2024 Apr
TI  - Prepared MW-Immunosensitizers Precisely Release NO to Downregulate HIF-1alpha 
      Expression and Enhance Immunogenic Cell Death.
PG  - e2308055
LID - 10.1002/smll.202308055 [doi]
AB  - Microwave thermotherapy (MWTT) has limited its application in the clinic due to 
      its high rate of metastasis and recurrence after treatment. Nitric oxide (NO) is 
      a gaseous molecule that can address the high metastasis and recurrence rates 
      after MWTT by increasing thermal sensitivity, down-regulating the expression of 
      hypoxia-inducible factor-1 (HIF-1), and inducing the immunogenic cell death 
      (ICD). Therefore, GaMOF-Arg is designed, a gallium-based organic skeleton 
      material derivative loaded with L-arginine (L-Arg), and coupled the 
      mitochondria-targeting drug of triphenylphosphine (TPP) on its surface to obtain 
      GaMOF-Arg-TPP (GAT) MW-immunosensitizers. When GAT MW-immunosensitizers are 
      introduced into mice through the tail vein, reactive oxygen species (ROS) are 
      generated and L-Arg is released under MW action. Then, L-Arg reacts with ROS to 
      generate NO, which not only downregulates HIF-1 expression to improve tumor 
      hypoxia exacerbated by MW, but also enhances immune responses by augment 
      calreticulin (CRT) exposure, high mobility group box 1 (HMGB1) release, and 
      T-cell proliferation to achieve prevention of tumor metastasis and recurrence. In 
      addition, NO can induce mitochondria damage to increase their sensitivity to 
      MWTT. This study provides a unique insight into the use of metal-organic 
      framework MW-immunosensitizers to enhance tumor therapy and offers a new way to 
      treat cancer efficiently.
CI  - (c) 2023 Wiley-VCH GmbH.
FAU - Guo, Wenna
AU  - Guo W
AD  - School of Optoelectronic Science and Engineering, University of Electronic 
      Science and Technology of China, Chengdu, Sichuan, 610054, P. R. China.
AD  - Laboratory of Controllable Preparation and Application of Nanomaterials, CAS Key 
      Laboratory of Cryogenics, Technical Institute of Physics and Chemistry, Chinese 
      Academy of Sciences, Beijing, 100190, P. R. China.
FAU - Chen, Zengzhen
AU  - Chen Z
AD  - Laboratory of Controllable Preparation and Application of Nanomaterials, CAS Key 
      Laboratory of Cryogenics, Technical Institute of Physics and Chemistry, Chinese 
      Academy of Sciences, Beijing, 100190, P. R. China.
FAU - Wu, Qiong
AU  - Wu Q
AD  - Laboratory of Controllable Preparation and Application of Nanomaterials, CAS Key 
      Laboratory of Cryogenics, Technical Institute of Physics and Chemistry, Chinese 
      Academy of Sciences, Beijing, 100190, P. R. China.
FAU - Tan, Longfei
AU  - Tan L
AD  - Laboratory of Controllable Preparation and Application of Nanomaterials, CAS Key 
      Laboratory of Cryogenics, Technical Institute of Physics and Chemistry, Chinese 
      Academy of Sciences, Beijing, 100190, P. R. China.
FAU - Ren, Xiangling
AU  - Ren X
AD  - Laboratory of Controllable Preparation and Application of Nanomaterials, CAS Key 
      Laboratory of Cryogenics, Technical Institute of Physics and Chemistry, Chinese 
      Academy of Sciences, Beijing, 100190, P. R. China.
FAU - Fu, Changhui
AU  - Fu C
AD  - Laboratory of Controllable Preparation and Application of Nanomaterials, CAS Key 
      Laboratory of Cryogenics, Technical Institute of Physics and Chemistry, Chinese 
      Academy of Sciences, Beijing, 100190, P. R. China.
FAU - Cao, Feng
AU  - Cao F
AD  - National Clinical Research Center for Geriatric Diseases & 2nd Medical Center, 
      Chinese PLA General Hospital, Beijing, 100853, P. R. China.
FAU - Gu, Deen
AU  - Gu D
AD  - School of Optoelectronic Science and Engineering, University of Electronic 
      Science and Technology of China, Chengdu, Sichuan, 610054, P. R. China.
FAU - Meng, Xianwei
AU  - Meng X
AUID- ORCID: 0000-0002-0350-4760
AD  - Laboratory of Controllable Preparation and Application of Nanomaterials, CAS Key 
      Laboratory of Cryogenics, Technical Institute of Physics and Chemistry, Chinese 
      Academy of Sciences, Beijing, 100190, P. R. China.
LA  - eng
GR  - 4222019/Natural Science Foundation of Beijing Municipality/
GR  - U20A20335/National Natural Science Foundation of China/
GR  - 62274021/National Natural Science Foundation of China/
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20231201
PL  - Germany
TA  - Small
JT  - Small (Weinheim an der Bergstrasse, Germany)
JID - 101235338
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - 0 (Hypoxia-Inducible Factor 1, alpha Subunit)
RN  - 0 (Reactive Oxygen Species)
RN  - 94ZLA3W45F (Arginine)
RN  - 0 (HMGB1 Protein)
RN  - 26D26OA393 (triphenylphosphine)
RN  - 0 (Organophosphorus Compounds)
SB  - IM
MH  - Animals
MH  - *Nitric Oxide/metabolism
MH  - *Hypoxia-Inducible Factor 1, alpha Subunit/metabolism
MH  - *Immunogenic Cell Death/drug effects
MH  - *Down-Regulation/drug effects
MH  - Mice
MH  - *Reactive Oxygen Species/metabolism
MH  - Microwaves
MH  - Arginine/chemistry
MH  - HMGB1 Protein/metabolism
MH  - Cell Line, Tumor
MH  - Mitochondria/metabolism/drug effects
MH  - Organophosphorus Compounds/chemistry/pharmacology
MH  - Humans
OTO - NOTNLM
OT  - hypoxia-inducible factor-1
OT  - immunogenic cell death
OT  - microwave thermotherapy
OT  - nitric oxide
EDAT- 2023/12/01 06:43
MHDA- 2024/04/26 00:52
CRDT- 2023/12/01 04:43
PHST- 2023/11/03 00:00 [revised]
PHST- 2023/09/14 00:00 [received]
PHST- 2024/04/26 00:52 [medline]
PHST- 2023/12/01 06:43 [pubmed]
PHST- 2023/12/01 04:43 [entrez]
AID - 10.1002/smll.202308055 [doi]
PST - ppublish
SO  - Small. 2024 Apr;20(17):e2308055. doi: 10.1002/smll.202308055. Epub 2023 Dec 1.