PMID- 38038863
OWN - NLM
STAT- MEDLINE
DCOM- 20240104
LR  - 20240116
IS  - 1749-0774 (Electronic)
IS  - 0914-7470 (Linking)
VI  - 37
IP  - 1
DP  - 2024 Jan
TI  - Treatment of type 2 diabetes mellitus with stem cells and antidiabetic drugs: a 
      dualistic and future-focused approach.
PG  - 54-84
LID - 10.1007/s13577-023-01007-0 [doi]
AB  - Type 2 Diabetes Mellitus (T2DM) accounts for more than 90% of total diabetes 
      mellitus cases all over the world. Obesity and lack of balance between energy 
      intake and energy expenditure are closely linked to T2DM. Initial pharmaceutical 
      treatment and lifestyle interventions can at times lead to remission but usually 
      help alleviate it to a certain extent and the condition remains, thus, recurrent 
      with the patient being permanently pharmaco-dependent. Mesenchymal stromal cells 
      (MSCs) are multipotent, self-renewing cells with the ability to secrete a variety 
      of biological factors that can help restore and repair injured tissues. 
      MSC-derived exosomes possess these properties of the original stem cells and are 
      potentially able to confer superior effects due to advanced cell-to-cell 
      signaling and the presence of stem cell-specific miRNAs. On the other hand, the 
      repository of antidiabetic agents is constantly updated with novel T2DM 
      disease-modifying drugs, with higher efficacy and increasingly convenient 
      delivery protocols. Delving deeply, this review details the latest progress and 
      ongoing studies related to the amalgamation of stem cells and antidiabetic drugs, 
      establishing how this harmonized approach can exert superior effects in the 
      management and potential reversal of T2DM.
CI  - (c) 2023. The Author(s) under exclusive licence to Japan Human Cell Society.
FAU - Arte, Priyamvada Amol
AU  - Arte PA
AUID- ORCID: 0000-0001-5078-2643
AD  - School of Biotechnology and Bioinformatics, DY Patil Deemed to Be University, CBD 
      Belapur, Navi Mumbai, Maharashtra, 400614, India. arte.priyamvada15@gmail.com.
AD  - Anatek Services PVT LTD, Sai Chamber, 10, Near Santacruz Railway Bridge, Sen 
      Nagar, Santacruz East, Mumbai, Maharashtra, 400055, India. 
      arte.priyamvada15@gmail.com.
FAU - Tungare, Kanchanlata
AU  - Tungare K
AUID- ORCID: 0000-0002-8130-4158
AD  - School of Biotechnology and Bioinformatics, DY Patil Deemed to Be University, CBD 
      Belapur, Navi Mumbai, Maharashtra, 400614, India.
FAU - Bhori, Mustansir
AU  - Bhori M
AUID- ORCID: 0000-0001-6493-1195
AD  - Inveniolife Technology PVT LTD, Office No.118, Grow More Tower, Plot No.5, Sector 
      2, Kharghar, Navi Mumbai, Maharashtra, 410210, India.
FAU - Jobby, Renitta
AU  - Jobby R
AUID- ORCID: 0000-0002-4804-5174
AD  - Amity Institute of Biotechnology, Amity University Maharashtra, Mumbai-Pune 
      Expressway, Bhatan, Panvel, Navi Mumbai, Maharashtra, 410206, India.
AD  - Amity Centre of Excellence in Astrobiology, Amity University Maharashtra, 
      Mumbai-Pune Expressway, Bhatan, Panvel, Navi Mumbai, Maharashtra, 410206, India.
FAU - Aich, Jyotirmoi
AU  - Aich J
AUID- ORCID: 0000-0002-6180-3785
AD  - School of Biotechnology and Bioinformatics, DY Patil Deemed to Be University, CBD 
      Belapur, Navi Mumbai, Maharashtra, 400614, India.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20231201
PL  - Japan
TA  - Hum Cell
JT  - Human cell
JID - 8912329
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (MicroRNAs)
SB  - IM
MH  - Humans
MH  - *Diabetes Mellitus, Type 2/drug therapy
MH  - Hypoglycemic Agents/pharmacology/therapeutic use
MH  - *Mesenchymal Stem Cells
MH  - *MicroRNAs
MH  - Multipotent Stem Cells
OTO - NOTNLM
OT  - Antidiabetic drugs
OT  - Combination therapy
OT  - Exosomes
OT  - Mesenchymal stromal cells
OT  - Novel approach
OT  - Type 2 diabetes mellitus
EDAT- 2023/12/01 12:41
MHDA- 2024/01/04 11:44
CRDT- 2023/12/01 11:10
PHST- 2023/05/06 00:00 [received]
PHST- 2023/10/31 00:00 [accepted]
PHST- 2024/01/04 11:44 [medline]
PHST- 2023/12/01 12:41 [pubmed]
PHST- 2023/12/01 11:10 [entrez]
AID - 10.1007/s13577-023-01007-0 [pii]
AID - 10.1007/s13577-023-01007-0 [doi]
PST - ppublish
SO  - Hum Cell. 2024 Jan;37(1):54-84. doi: 10.1007/s13577-023-01007-0. Epub 2023 Dec 1.