PMID- 38039622
OWN - NLM
STAT- MEDLINE
DCOM- 20240108
LR  - 20240108
IS  - 1873-3778 (Electronic)
IS  - 0021-9673 (Linking)
VI  - 1713
DP  - 2024 Jan 4
TI  - Dummy molecularly imprinted polymer-based solid-phase extraction method for the 
      determination of some phthalate monoesters in urine by gas chromatography-mass 
      spectrometry analysis.
PG  - 464532
LID - S0021-9673(23)00757-4 [pii]
LID - 10.1016/j.chroma.2023.464532 [doi]
AB  - A dummy molecularly imprinted polymer-based solid-phase extraction (SPE) sorbent 
      was used for the selective extraction of some phthalate monoesters, monoethyl 
      phthalate (MEP), monobutyl phthalate (MnBP) and mono-(2-ethylhexyl) phthalate 
      (MEHP) in urine prior to gas-chromatography-mass spectrometry (GC-MS) analysis. 
      Diethyl phthalate (DEP), a phthalate ester, was successfully used as a dummy 
      template to prepare selective sorbent for MEP, MnBP, and MEHP extraction. 
      DEP-imprinted poly(ethylene glycol dimethacrylate N-methacryloyl-l-tryptophan 
      methyl ester) (DPEMT) microbeads were synthesized by suspension polymerization 
      and characterized by Fourier Transform infrared spectroscopy (FTIR), scanning 
      electron microscopy (SEM) and Brunauer Emmet Teller (BET) analysis. The critical 
      parameters (i.e., pH, sorbent amount, ionic strength, sample volume, elution 
      solvent) affecting the extraction performance of the DPEMT-SPE sorbent were 
      optimized. Under optimum conditions, good linearities were obtained in the 
      concentration range of 4 to 60 ng/mL with determination coefficients (R(2)) of 
      greater than 0.9959. The developed SPE method provided low limits of detection 
      (LOD) of 0.05-1.20 ng/mL and limits of quantification (LOQ) of 0.18-4.01 ng/mL 
      with relative standard deviations (RSDs) of less than 8.95 % for intra- and 
      inter-day analyses. The proposed SPE method was used to analyze phthalate 
      monoesters in spiked urine samples, and recoveries of 97.45-109.26 % were 
      obtained. DPEMT-SPE sorbent was reused for 15 times without any losses of 
      performance. Consequently, a highly selective and sensitive SPE method based on a 
      dummy molecularly imprinted polymer combined with GC-MS was successfully 
      developed to monitor human phthalate exposure via urine samples.
CI  - Copyright (c) 2023. Published by Elsevier B.V.
FAU - Kucuk, Melike
AU  - Kucuk M
AD  - Department of Chemistry, Faculty of Arts and Science, Bursa Uludag University, 
      Gorukle, Bursa 16059, Turkey.
FAU - Osman, Bilgen
AU  - Osman B
AD  - Department of Chemistry, Faculty of Arts and Science, Bursa Uludag University, 
      Gorukle, Bursa 16059, Turkey.
FAU - Tumay Ozer, Elif
AU  - Tumay Ozer E
AD  - Department of Chemistry, Faculty of Arts and Science, Bursa Uludag University, 
      Gorukle, Bursa 16059, Turkey. Electronic address: etumay@uludag.edu.tr.
LA  - eng
PT  - Journal Article
DEP - 20231125
PL  - Netherlands
TA  - J Chromatogr A
JT  - Journal of chromatography. A
JID - 9318488
RN  - 0 (Molecularly Imprinted Polymers)
RN  - 6O7F7IX66E (phthalic acid)
RN  - FU2EWB60RT (mono-(2-ethylhexyl)phthalate)
RN  - ZI46LWZ45G (monobutyl phthalate)
RN  - 0 (monoethyl phthalate)
SB  - IM
MH  - Humans
MH  - Gas Chromatography-Mass Spectrometry/methods
MH  - *Molecularly Imprinted Polymers
MH  - Solid Phase Extraction/methods
MH  - *Molecular Imprinting/methods
OTO - NOTNLM
OT  - Dummy molecular imprinting
OT  - GC-MS
OT  - Phthalate monoester
OT  - SPE
OT  - Urine
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2023/12/02 00:41
MHDA- 2024/01/08 06:43
CRDT- 2023/12/01 18:03
PHST- 2023/09/06 00:00 [received]
PHST- 2023/11/13 00:00 [revised]
PHST- 2023/11/24 00:00 [accepted]
PHST- 2024/01/08 06:43 [medline]
PHST- 2023/12/02 00:41 [pubmed]
PHST- 2023/12/01 18:03 [entrez]
AID - S0021-9673(23)00757-4 [pii]
AID - 10.1016/j.chroma.2023.464532 [doi]
PST - ppublish
SO  - J Chromatogr A. 2024 Jan 4;1713:464532. doi: 10.1016/j.chroma.2023.464532. Epub 
      2023 Nov 25.