PMID- 38041410
OWN - NLM
STAT- MEDLINE
DCOM- 20240319
LR  - 20240320
IS  - 1097-0096 (Electronic)
IS  - 0091-2751 (Linking)
VI  - 52
IP  - 3
DP  - 2024 Mar-Apr
TI  - Association of the TNF-alpha-308G>A gene polymorphism with left ventricular geometry 
      and functional abnormalities in obstructive sleep apnea subjects.
PG  - 241-248
LID - 10.1002/jcu.23624 [doi]
AB  - OBJECTIVE: Tumor necrosis factor-alpha (TNF-alpha) can induce left ventricular 
      remodeling. In this study, we investigated whether the TNF-alpha-308G>A polymorphism 
      is associated with left ventricular geometry (LVG) and left ventricular 
      functional abnormalities in obstructive sleep apnea (OSA) subjects. METHODS: Two 
      hundred and seventy-eight subjects were enrolled. Echocardiography and genetic 
      data were assessed in all patients. Geometric patterns of the left ventricle were 
      determined from the relative wall thickness and left ventricular mass index 
      (LVMI). Genetic analysis for the TNF-alpha-308G>A SNP rs1800629 was identified by 
      Sanger sequencing. The correlations of the TNF-alpha-308G>A polymorphism with LVG and 
      left ventricular function were analyzed by difference analysis and logistic 
      regression. RESULTS: The chi-square test showed that there were differences in 
      genotype distributions among the four groups (p = 0.033), such that the frequency 
      of GA+AA genotypes was significantly higher in the concentric hypertrophy group 
      than in the normal geometry group (p < 0.05). Independent sample T tests showed 
      that the GA+AA genotypes had higher IVST, LVPWT, LVMI, E/e' values, and lower e' 
      values than those of the GG genotype (p < 0.05). Logistic regression analysis 
      showed that the TNF-alpha-308G>A polymorphism was independently correlated with 
      eccentric hypertrophy (OR = 2.456, p = 0.047) and concentric hypertrophy 
      (OR = 2.456, p = 0.047). CONCLUSION: In OSA patients, the TNF-alpha-308G>A 
      polymorphism was linked to LVG and abnormal left ventricular diastolic function, 
      suggesting that the TNF-alpha-308G>A polymorphism may have an important influence on 
      LVG alterations.
CI  - (c) 2023 Wiley Periodicals LLC.
FAU - Chen, Shuqiong
AU  - Chen S
AUID- ORCID: 0009-0006-0672-8619
AD  - Department of Ultrasound, First Hospital of Shanxi Medical University, Taiyuan, 
      Shanxi, China.
FAU - Wang, Jian
AU  - Wang J
AD  - Department of Ultrasound, First Hospital of Shanxi Medical University, Taiyuan, 
      Shanxi, China.
FAU - Shui, Wen
AU  - Shui W
AD  - Department of Ultrasound, First Hospital of Shanxi Medical University, Taiyuan, 
      Shanxi, China.
FAU - Xing, Xueqing
AU  - Xing X
AD  - Department of Ultrasound, First Hospital of Shanxi Medical University, Taiyuan, 
      Shanxi, China.
FAU - Zhang, Zhenxia
AU  - Zhang Z
AD  - Department of Respiratory, First Hospital of Shanxi Medical University, Taiyuan, 
      Shanxi, China.
FAU - Hou, Ran
AU  - Hou R
AD  - Department of Ultrasound, First Hospital of Shanxi Medical University, Taiyuan, 
      Shanxi, China.
LA  - eng
GR  - 82371989/National Natural Science Foundation of China/
GR  - 202204041101045/Shanxi Province Science and Technology Cooperation and Exchange 
      Special Project/
PT  - Journal Article
DEP - 20231201
PL  - United States
TA  - J Clin Ultrasound
JT  - Journal of clinical ultrasound : JCU
JID - 0401663
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0 (TNF protein, human)
SB  - IM
MH  - Humans
MH  - Heart Ventricles/diagnostic imaging
MH  - Hypertrophy, Left Ventricular
MH  - Polymorphism, Genetic
MH  - *Sleep Apnea, Obstructive/genetics/complications
MH  - *Tumor Necrosis Factor-alpha/genetics
OTO - NOTNLM
OT  - echocardiography
OT  - gene polymorphism
OT  - left ventricular geometry
OT  - obstructive sleep apnea
OT  - tumor necrosis factor-alpha
EDAT- 2023/12/02 06:41
MHDA- 2024/03/19 06:44
CRDT- 2023/12/02 03:38
PHST- 2023/11/18 00:00 [revised]
PHST- 2023/10/08 00:00 [received]
PHST- 2023/11/22 00:00 [accepted]
PHST- 2024/03/19 06:44 [medline]
PHST- 2023/12/02 06:41 [pubmed]
PHST- 2023/12/02 03:38 [entrez]
AID - 10.1002/jcu.23624 [doi]
PST - ppublish
SO  - J Clin Ultrasound. 2024 Mar-Apr;52(3):241-248. doi: 10.1002/jcu.23624. Epub 2023 
      Dec 1.