PMID- 38042587
OWN - NLM
STAT- MEDLINE
DCOM- 20231204
LR  - 20240512
IS  - 1557-8445 (Electronic)
IS  - 0065-2776 (Print)
IS  - 0065-2776 (Linking)
VI  - 160
DP  - 2023
TI  - Immunometabolism of dendritic cells in health and disease.
PG  - 83-116
LID - S0065-2776(23)00032-9 [pii]
LID - 10.1016/bs.ai.2023.10.002 [doi]
AB  - Dendritic cells (DCs) are crucial mediators that bridge the innate and adaptive 
      immune responses. Cellular rewiring of metabolism is an emerging regulator of the 
      activation, migration, and functional specialization of DC subsets in specific 
      microenvironments and immunological conditions. DCs undergo metabolic adaptation 
      to exert immunogenic or tolerogenic effects in different contexts. Also, beyond 
      their intracellular metabolic and signaling roles, metabolites and nutrients 
      mediate the intercellular crosstalk between DCs and other cell types, and such 
      crosstalk orchestrates DC function and immune responses. Here, we provide a 
      comprehensive review of the metabolic regulation of DC biology in various 
      contexts and summarize the current understanding of such regulation in directing 
      immune homeostasis and inflammation, specifically with respect to infections, 
      autoimmunity, tolerance, cancer, metabolic diseases, and crosstalk with gut 
      microbes. Understanding context-specific metabolic alterations in DCs may 
      identify mechanisms for physiological and pathological functions of DCs and yield 
      potential opportunities for therapeutic targeting of DC metabolism in many 
      diseases.
CI  - Copyright (c) 2023. Published by Elsevier Inc.
FAU - Guo, Chuansheng
AU  - Guo C
AD  - Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, 
      United States.
FAU - Chi, Hongbo
AU  - Chi H
AD  - Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, 
      United States. Electronic address: hongbo.chi@stjude.org.
LA  - eng
GR  - R01 AI131703/AI/NIAID NIH HHS/United States
GR  - R01 AI150514/AI/NIAID NIH HHS/United States
GR  - R01 AI150544/AI/NIAID NIH HHS/United States
GR  - R37 AI105887/AI/NIAID NIH HHS/United States
GR  - R35 CA253188/CA/NCI NIH HHS/United States
GR  - R01 AI150241/AI/NIAID NIH HHS/United States
GR  - R01 AI140761/AI/NIAID NIH HHS/United States
GR  - R01 AI105887/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20231025
PL  - United States
TA  - Adv Immunol
JT  - Advances in immunology
JID - 0370425
SB  - IM
MH  - Humans
MH  - *Autoimmunity
MH  - *Immune Tolerance
MH  - Signal Transduction
MH  - Inflammation/metabolism
MH  - Dendritic Cells
PMC - PMC11086980
MID - NIHMS1980539
COIS- Declaration of competing interest H.C. consulted for consulted Kumquat 
      Biosciences and Chugai Pharmaceutical Co.
EDAT- 2023/12/03 00:41
MHDA- 2023/12/04 12:42
PMCR- 2024/10/25
CRDT- 2023/12/02 21:01
PHST- 2024/10/25 00:00 [pmc-release]
PHST- 2023/12/04 12:42 [medline]
PHST- 2023/12/03 00:41 [pubmed]
PHST- 2023/12/02 21:01 [entrez]
AID - S0065-2776(23)00032-9 [pii]
AID - 10.1016/bs.ai.2023.10.002 [doi]
PST - ppublish
SO  - Adv Immunol. 2023;160:83-116. doi: 10.1016/bs.ai.2023.10.002. Epub 2023 Oct 25.