PMID- 38043716
OWN - NLM
STAT- MEDLINE
DCOM- 20240129
LR  - 20240206
IS  - 1873-2968 (Electronic)
IS  - 0006-2952 (Linking)
VI  - 220
DP  - 2024 Feb
TI  - Gestational exposure to bisphenol AF causes endocrine disorder of corpus luteum 
      by altering ovarian SIRT-1/Nrf2/NF-kB expressions and macrophage proangiogenic 
      function in mice.
PG  - 115954
LID - S0006-2952(23)00547-6 [pii]
LID - 10.1016/j.bcp.2023.115954 [doi]
AB  - Bisphenol AF (BPAF) is extensively used in industrial production as an emerging 
      substitute for the earlier-used bisphenol A (BPA). Studies have found that BPAF 
      had stronger estrogenic activities than BPA. However, the effects of BPAF on the 
      luteal function of pregnancy and its possible mechanisms are largely unknown. In 
      this study, pregnant mice were orally administered 3.0 and 30 mg/kg/day of BPAF 
      from gestational day (GD) 1 to 8, and samples were collected on GD 8 and GD 19. 
      Results showed that maternal exposure to BPAF impaired embryo implantation and 
      reduced ovarian weight, and interfered with steroid hormone secretion, and 
      decreased the numbers and areas of corpus luteum. BPAF treatment significantly 
      down-regulated expression levels of ovarian Star, Cyp11a, Hsd3b1, and Cyp19a1 
      mRNA and CYP19a1 and ERalpha proteins. BPAF also disrupted markers of 
      redox/inflammation key, including silent information regulator of transcript-1 
      (SIRT-1), nuclear factor erythroid 2-related factor 2 (Nrf2), and nuclear factor 
      kappa-B (NF-kB) expressions along with reduced ovarian antioxidant (CAT and SOD) 
      capacity, enhanced oxidant (H(2)O(2) and MDA) and inflammatory factor (Il6 and 
      Tnfa) activities. Furthermore, BPAF exposure inhibited macrophages with a 
      pro-angiogenic phenotype that specifically expressed TIE-2, accompanied by 
      inhibition of angiogenic factors (HIF1a, VEGFA, and Angpt1) and promotion of 
      anti-angiogenic factor Ang-2 to suppress luteal angiogenesis. In addition, BPAF 
      administration also induced luteolysis and apoptosis by up-regulation of COX-2, 
      BAX/BCL-2, and Cleaved-Caspase-3 protein. Collectively, our current data 
      demonstrated that gestational exposure to BPAF caused luteal endocrine disorder 
      by altering ovarian SIRT-1/Nrf2/NF-kB expressions and macrophage proangiogenic 
      function in mice.
CI  - Copyright (c) 2023 Elsevier Inc. All rights reserved.
FAU - Lu, Siying
AU  - Lu S
AD  - Department of Physiology, Basic Medical College, Nanchang University, Nanchang, 
      Jiangxi 330006, PR China. Electronic address: lusiying@email.ncu.edu.cn.
FAU - Liu, Mengling
AU  - Liu M
AD  - Nursing School of Jiujiang University, Jiujiang, Jiangxi 332000, PR China. 
      Electronic address: 304916968@qq.com.
FAU - Liu, Hui
AU  - Liu H
AD  - Department of Physiology, Basic Medical College, Nanchang University, Nanchang, 
      Jiangxi 330006, PR China. Electronic address: hhcomeon@126.com.
FAU - Yang, Chuanzhen
AU  - Yang C
AD  - Department of Physiology, Basic Medical College, Nanchang University, Nanchang, 
      Jiangxi 330006, PR China. Electronic address: yangczhen@126.com.
FAU - Zhu, Jun
AU  - Zhu J
AD  - Department of Physiology, Basic Medical College, Nanchang University, Nanchang, 
      Jiangxi 330006, PR China. Electronic address: zj78_12@163.com.
FAU - Ling, Yan
AU  - Ling Y
AD  - Department of Obstetrics and Gynecology, Jiangxi Provincial People's Hospital 
      Affiliated Nanchang University, Nanchang, Jiangxi 330006, PR China. Electronic 
      address: lingyan1205@163.com.
FAU - Kuang, Haibin
AU  - Kuang H
AD  - Department of Physiology, Basic Medical College, Nanchang University, Nanchang, 
      Jiangxi 330006, PR China. Electronic address: kuanghaibin@ncu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20231201
PL  - England
TA  - Biochem Pharmacol
JT  - Biochemical pharmacology
JID - 0101032
RN  - 0 (NF-kappa B)
RN  - OH7IX8A37J (4,4'-hexafluorisopropylidene diphenol)
RN  - 0 (NF-E2-Related Factor 2)
RN  - BBX060AN9V (Hydrogen Peroxide)
RN  - MLT3645I99 (bisphenol A)
RN  - 0 (Benzhydryl Compounds)
RN  - 0 (Fluorocarbons)
RN  - 0 (Phenols)
SB  - IM
MH  - Pregnancy
MH  - Female
MH  - Mice
MH  - Animals
MH  - *NF-kappa B/genetics
MH  - *NF-E2-Related Factor 2/genetics
MH  - Hydrogen Peroxide
MH  - Benzhydryl Compounds
MH  - Corpus Luteum
MH  - Macrophages
MH  - *Fluorocarbons
MH  - *Phenols
OTO - NOTNLM
OT  - Angiogenesis
OT  - Corpus luteum
OT  - Endocrine-disrupting compounds
OT  - Macrophage
OT  - SIRT-1/Nrf2/NF-kB
OT  - bisphenol AF
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2023/12/04 00:42
MHDA- 2024/01/29 06:43
CRDT- 2023/12/03 19:27
PHST- 2023/07/18 00:00 [received]
PHST- 2023/11/27 00:00 [revised]
PHST- 2023/11/28 00:00 [accepted]
PHST- 2024/01/29 06:43 [medline]
PHST- 2023/12/04 00:42 [pubmed]
PHST- 2023/12/03 19:27 [entrez]
AID - S0006-2952(23)00547-6 [pii]
AID - 10.1016/j.bcp.2023.115954 [doi]
PST - ppublish
SO  - Biochem Pharmacol. 2024 Feb;220:115954. doi: 10.1016/j.bcp.2023.115954. Epub 2023 
      Dec 1.