PMID- 38044549
OWN - NLM
STAT- MEDLINE
DCOM- 20231216
LR  - 20240220
IS  - 1520-6882 (Electronic)
IS  - 0003-2700 (Linking)
VI  - 95
IP  - 49
DP  - 2023 Dec 12
TI  - Enrichment-Sensing All-in-One Strategy Integrated in the La(OH)(3)-Au@AgNPs 
      Substrate for Rapid Surface-Enhanced Raman Spectroscopy Analysis of Purine 
      Components.
PG  - 18149-18157
LID - 10.1021/acs.analchem.3c03604 [doi]
AB  - Improving the speediness of complex sample analysis has attracted much research 
      interest in analytical science. In this work, an enrichment-sensing all-in-one 
      strategy was presented for rapid surface-enhanced Raman spectroscopy (SERS) 
      analysis of purine components by using the La(OH)(3)-Au@AgNPs nanocomposite. 
      Two-dimensional (2D) La(OH)(3) nanosheets with nanothickness and accessible 
      active sites not only acted as efficient media for the rapid enrichment of 
      analytes but also provided flat planes for the intensive decoration of Au@AgNPs 
      nanoparticles to amplify the SERS signals of adsorbed analytes. The nanocomposite 
      could realize the rapid enrichment-sensing of purine components in 1 min, 
      including mercaptopurine, thioguanine, adenine, and purine. Subsequently, the 
      surface adsorption behaviors were explored by density functional theory and the 
      enhancement mechanisms were simulated by the finite-difference time-domain 
      method. Moreover, the nanocomposite also exhibited good SERS performances with 
      relative standard deviations (RSDs) of uniformity less than 6.5% (n = 23), RSDs 
      of batch-to-batch stability less than 7.3% (n = 9), and long-term stability over 
      9 weeks with RSDs within 6.6%. Finally, the enrichment-sensing strategy was 
      applied for the rapid SERS analysis of two projects: mercaptopurine in tablets 
      and adenine in beers with detection limits of 6.0 and 0.76 mug/L and spiked 
      recoveries of 90.9-100 and 84.2-101%, respectively. Benefiting from the 
      high-performance enrichment medium and closely packed plasmonic nanoparticles, 
      the enrichment-sensing all-in-one strategy possesses great potential for rapid 
      on-site detection in food safety and pharmaceutical analysis.
FAU - Lai, Huasheng
AU  - Lai H
AUID- ORCID: 0000-0002-7985-8290
AD  - School of Chemistry, Sun Yat-sen University, Guangzhou 510006, China.
FAU - Li, Gongke
AU  - Li G
AUID- ORCID: 0000-0003-3750-6358
AD  - School of Chemistry, Sun Yat-sen University, Guangzhou 510006, China.
FAU - Zhang, Zhuomin
AU  - Zhang Z
AD  - School of Chemistry, Sun Yat-sen University, Guangzhou 510006, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20231203
PL  - United States
TA  - Anal Chem
JT  - Analytical chemistry
JID - 0370536
RN  - E7WED276I5 (Mercaptopurine)
RN  - JAC85A2161 (Adenine)
SB  - IM
MH  - Spectrum Analysis, Raman/methods
MH  - Mercaptopurine
MH  - *Nanocomposites/chemistry
MH  - Adenine
MH  - *Metal Nanoparticles/chemistry
EDAT- 2023/12/04 06:42
MHDA- 2023/12/17 09:45
CRDT- 2023/12/04 00:42
PHST- 2023/12/17 09:45 [medline]
PHST- 2023/12/04 06:42 [pubmed]
PHST- 2023/12/04 00:42 [entrez]
AID - 10.1021/acs.analchem.3c03604 [doi]
PST - ppublish
SO  - Anal Chem. 2023 Dec 12;95(49):18149-18157. doi: 10.1021/acs.analchem.3c03604. 
      Epub 2023 Dec 3.