PMID- 38046672
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231205
IS  - 2633-1055 (Electronic)
IS  - 2633-1055 (Linking)
VI  - 18
DP  - 2023
TI  - Positive Association Between the Immunogenetic Human Leukocyte Antigen (HLA) 
      Profiles of Multiple Sclerosis and Brain Cancer.
PG  - 26331055231214543
LID - 10.1177/26331055231214543 [doi]
LID - 26331055231214543
AB  - Previous research has documented elevated risk of brain cancer in patients with 
      multiple sclerosis (MS). Separately, human leukocyte antigen (HLA) has been 
      implicated in protection or susceptibility for both conditions. The aim of the 
      current study was to assess a possible role of shared immunogenetic influence on 
      risk of MS and brain cancer. We first identified an immunogenetic profile for 
      each condition based on the covariance between the population frequency of 127 
      high-resolution HLA alleles and the population prevalence of each condition in 14 
      Continental Western European countries and then evaluated the correspondence 
      between MS and brain cancer immunogenetic profiles. Also, since each individual 
      carries 12 HLA alleles (2 x 6 genes), we estimated HLA protection and 
      susceptibility for MS and brain cancer at the individual level. We found that the 
      immunogenetic profiles of MS and brain cancer were highly correlated overall 
      (P < .001) and across all 6 HLA genes with the strongest association observed for 
      DRB1, followed by DQB1 and HLA-A. These findings of immunogenetic overlap between 
      MS and brain cancer are discussed in light of the role of HLA in the immune 
      system response to viruses and other foreign antigens.
CI  - (c) The Author(s) 2023.
FAU - James, Lisa M
AU  - James LM
AUID- ORCID: 0000-0001-9021-0690
AD  - Department of Veterans Affairs Health Care System, The HLA Research Group, Brain 
      Sciences Center, Minneapolis, MN, USA.
AD  - Department of Neuroscience, University of Minnesota Medical School, Minneapolis, 
      MN, USA.
AD  - Department of Psychiatry, University of Minnesota Medical School, Minneapolis, 
      MN, USA.
FAU - Georgopoulos, Apostolos P
AU  - Georgopoulos AP
AUID- ORCID: 0000-0003-4412-725X
AD  - Department of Veterans Affairs Health Care System, The HLA Research Group, Brain 
      Sciences Center, Minneapolis, MN, USA.
AD  - Department of Neuroscience, University of Minnesota Medical School, Minneapolis, 
      MN, USA.
AD  - Department of Psychiatry, University of Minnesota Medical School, Minneapolis, 
      MN, USA.
AD  - Department of Neurology, University of Minnesota Medical School, Minneapolis, MN, 
      USA.
LA  - eng
PT  - Journal Article
DEP - 20231201
PL  - United States
TA  - Neurosci Insights
JT  - Neuroscience insights
JID - 101760670
PMC - PMC10693228
OTO - NOTNLM
OT  - Multiple sclerosis
OT  - brain cancer
OT  - human leukocyte antigen
OT  - immunogenetics
COIS- The author(s) declared no potential conflicts of interest with respect to the 
      research, authorship, and/or publication of this article.
EDAT- 2023/12/04 06:42
MHDA- 2023/12/04 06:43
PMCR- 2023/12/01
CRDT- 2023/12/04 05:06
PHST- 2023/04/12 00:00 [received]
PHST- 2023/10/31 00:00 [revised]
PHST- 2023/12/04 06:43 [medline]
PHST- 2023/12/04 06:42 [pubmed]
PHST- 2023/12/04 05:06 [entrez]
PHST- 2023/12/01 00:00 [pmc-release]
AID - 10.1177_26331055231214543 [pii]
AID - 10.1177/26331055231214543 [doi]
PST - epublish
SO  - Neurosci Insights. 2023 Dec 1;18:26331055231214543. doi: 
      10.1177/26331055231214543. eCollection 2023.