PMID- 38049036
OWN - NLM
STAT- MEDLINE
DCOM- 20240214
LR  - 20240214
IS  - 1872-8227 (Electronic)
IS  - 0168-8227 (Linking)
VI  - 207
DP  - 2024 Jan
TI  - Potential risk factors for mild cognitive impairment among patients with type 2 
      diabetes experiencing hypoglycemia.
PG  - 111036
LID - S0168-8227(23)00799-4 [pii]
LID - 10.1016/j.diabres.2023.111036 [doi]
AB  - AIMS: This study examined the association between hypoglycemia and mild cognitive 
      impairment (MCI) among patients with type 2 diabetes mellitus (T2DM) and 
      identified risk factors for MCI in patients with hypoglycemia. METHODS: In this 
      retrospective study, 328 patients with T2DM were screened in 2019 and followed up 
      in 2022. Cognitive performance was assessed using the Montreal Cognitive 
      Assessment (MoCA). The diagnosis of MCI was based on established criteria. Risk 
      ratio (RR) with 95 % confidence intervals (CI) was calculated to estimate the 
      risk of MCI. Univariate and multivariate logistic regression analyses were 
      conducted to identify risk factors for MCI in those with hypoglycemia. RESULTS: 
      Patients with hypoglycemia had lower cognitive performance 3 years later. The RR 
      of MCI was 2.221 (95 % CI 1.269-3.885). Multivariate logistic analysis showed 
      that low grip strength, existing diabetic retinopathy (DR), and multiple 
      hypoglycemia episodes were associated with higher odds of MCI in patients with 
      hypoglycemia (adjusted odds ratio [OR] 0.909 [95 % CI 0.859-0.963]), 3.078 [95 % 
      CI 1.158-12.358], and 4.642 [95 % CI 1.284-16.776], respectively, all P < 0.05). 
      CONCLUSIONS: Hypoglycemia increased MCI risk among patients with T2DM. Low grip 
      strength, DR, and multiple hypoglycemia episodes may be potential risk factors 
      for hypoglycemia-associated MCI.
CI  - Copyright (c) 2023. Published by Elsevier B.V.
FAU - Gao, Ruonan
AU  - Gao R
AD  - Department of Endocrinology, Fujian Medical University Union Hospital, Fuzhou, 
      China.
FAU - Zhan, Menglan
AU  - Zhan M
AD  - Department of Endocrinology, Fujian Medical University Union Hospital, Fuzhou, 
      China.
FAU - Ke, Sujie
AU  - Ke S
AD  - Department of Endocrinology, Fujian Medical University Union Hospital, Fuzhou, 
      China.
FAU - Wu, Kejun
AU  - Wu K
AD  - Department of Endocrinology, Fujian Medical University Union Hospital, Fuzhou, 
      China.
FAU - He, Guanlian
AU  - He G
AD  - Department of Endocrinology, Fujian Medical University Union Hospital, Fuzhou, 
      China.
FAU - Qi, Liqin
AU  - Qi L
AD  - Department of Endocrinology, Fujian Medical University Union Hospital, Fuzhou, 
      China.
FAU - Liu, Xiaoying
AU  - Liu X
AD  - Department of Endocrinology, Fujian Medical University Union Hospital, Fuzhou, 
      China.
FAU - Liu, Xiaohong
AU  - Liu X
AD  - Department of Endocrinology, Fujian Medical University Union Hospital, Fuzhou, 
      China.
FAU - Wang, Lijing
AU  - Wang L
AD  - Department of Endocrinology, Fujian Medical University Union Hospital, Fuzhou, 
      China. Electronic address: fjxhwlj@126.com.
FAU - Liu, Libin
AU  - Liu L
AD  - Department of Endocrinology, Fujian Medical University Union Hospital, Fuzhou, 
      China. Electronic address: Libinliu@fjmu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20231202
PL  - Ireland
TA  - Diabetes Res Clin Pract
JT  - Diabetes research and clinical practice
JID - 8508335
SB  - IM
MH  - Humans
MH  - *Diabetes Mellitus, Type 2/complications/psychology
MH  - Retrospective Studies
MH  - Risk Factors
MH  - *Cognitive Dysfunction/epidemiology/etiology
MH  - *Hypoglycemia/complications/epidemiology
OTO - NOTNLM
OT  - Grip strength
OT  - Hypoglycemia
OT  - Mild cognitive impairment
OT  - Potential risk factors
OT  - Type 2 diabetes mellitus
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2023/12/05 00:41
MHDA- 2024/02/10 14:45
CRDT- 2023/12/04 19:26
PHST- 2023/10/13 00:00 [received]
PHST- 2023/11/25 00:00 [revised]
PHST- 2023/12/01 00:00 [accepted]
PHST- 2024/02/10 14:45 [medline]
PHST- 2023/12/05 00:41 [pubmed]
PHST- 2023/12/04 19:26 [entrez]
AID - S0168-8227(23)00799-4 [pii]
AID - 10.1016/j.diabres.2023.111036 [doi]
PST - ppublish
SO  - Diabetes Res Clin Pract. 2024 Jan;207:111036. doi: 10.1016/j.diabres.2023.111036. 
      Epub 2023 Dec 2.