PMID- 38050866
OWN - NLM
STAT- MEDLINE
DCOM- 20240202
LR  - 20240410
IS  - 1469-445X (Electronic)
IS  - 0958-0670 (Print)
IS  - 0958-0670 (Linking)
VI  - 109
IP  - 2
DP  - 2024 Feb
TI  - Glucose metabolism and autonomic function in healthy individuals and patients 
      with type 2 diabetes mellitus at rest and during exercise.
PG  - 214-226
LID - 10.1113/EP091444 [doi]
AB  - Autonomic dysfunction is a common complication of type 2 diabetes mellitus 
      (T2DM). However, the character of dysfunction varies in different reports. 
      Differences in measurement methodology and complications might have influenced 
      the inconsistent results. We sought to evaluate comprehensively the relationship 
      between abnormal glucose metabolism and autonomic function at rest and the 
      response to exercise in healthy individuals and T2DM patients. We hypothesized 
      that both sympathetic and parasympathetic indices would decrease with the 
      progression of abnormal glucose metabolism in individuals with few complications 
      related to high sympathetic tone. Twenty healthy individuals and 11 T2DM patients 
      without clinically evident cardiovascular disease other than controlled 
      hypertension were examined. Resting muscle sympathetic nerve activity (MSNA), 
      heart rate variability, spontaneous cardiovagal baroreflex sensitivity (CBRS), 
      sympathetic baroreflex sensitivity and the MSNA response to handgrip exercise 
      were measured. Resting MSNA was lower in patients with T2DM than in healthy 
      control subjects (P = 0.011). Resting MSNA was negatively correlated with 
      haemoglobin A(1c) in all subjects (R = -0.45, P = 0.024). The parasympathetic 
      components of heart rate variability and CBRS were negatively correlated with 
      glycaemic/insulin indices in all subjects and even in the control group only 
      (all, P < 0.05). In all subjects, the MSNA response to exercise was positively 
      correlated with fasting blood glucose (R = 0.69, P < 0.001). Resting sympathetic 
      activity and parasympathetic modulation of heart rate were decreased in 
      relationship to abnormal glucose metabolism. Meanwhile, the sympathetic responses 
      to handgrip were preserved in diabetics. The responses were correlated with 
      glucose/insulin parameters throughout diabetic and control subjects. These 
      results suggest the importance of a comprehensive assessment of autonomic 
      function in T2DM.
CI  - (c) 2023 The Authors. Experimental Physiology published by John Wiley & Sons Ltd on 
      behalf of The Physiological Society.
FAU - Hamaoka, Takuto
AU  - Hamaoka T
AD  - Penn State Heart and Vascular Institute, Pennsylvania State University College of 
      Medicine, Hershey, Pennsylvania, USA.
FAU - Leuenberger, Urs A
AU  - Leuenberger UA
AD  - Penn State Heart and Vascular Institute, Pennsylvania State University College of 
      Medicine, Hershey, Pennsylvania, USA.
FAU - Drew, Rachel C
AU  - Drew RC
AUID- ORCID: 0000-0001-8001-1946
AD  - Penn State Heart and Vascular Institute, Pennsylvania State University College of 
      Medicine, Hershey, Pennsylvania, USA.
AD  - Department of Exercise and Health Sciences, University of Massachusetts Boston, 
      Boston, Massachusetts, USA.
FAU - Murray, Matthew
AU  - Murray M
AD  - Penn State Heart and Vascular Institute, Pennsylvania State University College of 
      Medicine, Hershey, Pennsylvania, USA.
FAU - Blaha, Cheryl
AU  - Blaha C
AD  - Penn State Heart and Vascular Institute, Pennsylvania State University College of 
      Medicine, Hershey, Pennsylvania, USA.
FAU - Luck, Jonathan Carter
AU  - Luck JC
AD  - Penn State Heart and Vascular Institute, Pennsylvania State University College of 
      Medicine, Hershey, Pennsylvania, USA.
FAU - Sinoway, Lawrence I
AU  - Sinoway LI
AD  - Penn State Heart and Vascular Institute, Pennsylvania State University College of 
      Medicine, Hershey, Pennsylvania, USA.
FAU - Cui, Jian
AU  - Cui J
AD  - Penn State Heart and Vascular Institute, Pennsylvania State University College of 
      Medicine, Hershey, Pennsylvania, USA.
LA  - eng
GR  - R01 HL144781/NH/NIH HHS/United States
GR  - R01 HL141198/HL/NHLBI NIH HHS/United States
GR  - UL1 TR002014/NH/NIH HHS/United States
GR  - UL1 TR002014/TR/NCATS NIH HHS/United States
GR  - R01 HL164571/HL/NHLBI NIH HHS/United States
GR  - R01HL164571/NH/NIH HHS/United States
GR  - R01 HL144781/HL/NHLBI NIH HHS/United States
GR  - R01 HL141198/NH/NIH HHS/United States
PT  - Journal Article
DEP - 20231205
PL  - England
TA  - Exp Physiol
JT  - Experimental physiology
JID - 9002940
RN  - IY9XDZ35W2 (Glucose)
RN  - 0 (Insulins)
SB  - IM
MH  - Humans
MH  - *Diabetes Mellitus, Type 2
MH  - Hand Strength
MH  - Blood Pressure/physiology
MH  - Sympathetic Nervous System/physiology
MH  - Baroreflex/physiology
MH  - Heart Rate/physiology
MH  - Glucose
MH  - *Insulins
MH  - Muscle, Skeletal/physiology
PMC - PMC10841625
MID - NIHMS1942866
OTO - NOTNLM
OT  - heart rate variability
OT  - muscle sympathetic nerve activity
OT  - type 2 diabetes mellitus
COIS- The authors declare no conflicts of interest.
EDAT- 2023/12/05 17:44
MHDA- 2024/02/02 06:43
PMCR- 2023/12/05
CRDT- 2023/12/05 07:13
PHST- 2023/08/03 00:00 [received]
PHST- 2023/10/31 00:00 [accepted]
PHST- 2024/02/02 06:43 [medline]
PHST- 2023/12/05 17:44 [pubmed]
PHST- 2023/12/05 07:13 [entrez]
PHST- 2023/12/05 00:00 [pmc-release]
AID - EPH13454 [pii]
AID - 10.1113/EP091444 [doi]
PST - ppublish
SO  - Exp Physiol. 2024 Feb;109(2):214-226. doi: 10.1113/EP091444. Epub 2023 Dec 5.