PMID- 38051451
OWN - NLM
STAT- MEDLINE
DCOM- 20240126
LR  - 20240308
IS  - 1573-7446 (Electronic)
IS  - 0165-7380 (Print)
IS  - 0165-7380 (Linking)
VI  - 48
IP  - 1
DP  - 2024 Feb
TI  - The effect of enterocin A/P dipeptide on growth performance, 
      glutathione-peroxidase activity, IgA secretion and jejunal morphology in rabbits 
      after experimental methicillin-resistant Staphylococcus epidermidis P3Tr2a 
      Infection.
PG  - 507-517
LID - 10.1007/s11259-023-10277-w [doi]
AB  - The increasing frequency of methicillin-resistant (MR) staphylococci in humans 
      and animals need special attention for their difficult treatment and zoonotic 
      character, therefore novel antimicrobial compounds on a natural base against 
      antibiotic-resistant bacteria are requested. Currently, bacteriocins/enterocins 
      present a new promising way to overcome this problem, both in prevention and 
      treatment. Therefore, the preventive and medicinal effect of dipeptide enterocin 
      EntA/P was evaluated against MR Staphylococcus epidermidis SEP3/Tr2a strain in a 
      rabbit model, testing their influence on growth performance, 
      glutathione-peroxidase (GPx) enzyme activity, phagocytic activity (PA), secretory 
      (s)IgA, and jejunal morphometry (JM). Eighty-eight rabbits (aged 35 days, meat 
      line M91, both sexes) were divided into experimental groups S (SEP3/Tr2a strain; 
      1.0 x 10(5) CFU/mL; dose 500microL/animal/day for 7 days, between days 14 and 21 to 
      simulate the pathogen attack), E (EntA/P; 50 microL/animal/day, 25,600 AU/mL in two 
      intervals, for preventive effect between days 0 and 14; for medicinal effect 
      between days 28 and 42), E + S (EntA/P + SEP3/Tr2a; preventive effect; 
      SEP3/Tr2a + EntA/P; medicinal effect) and control group (C; without additives). 
      Higher body weight was recorded in all experimental groups (p < 0.001) compared 
      to control data. The negative influence/attack of the SEP3Tra2 strain on the 
      intestinal immunity and environment was reflected as decreased GPx activity, 
      worse JM parameters and higher sIgA concentration in infected rabbits. These 
      results suggest the promising preventive use of EntA/P to improve the immunity 
      and growth of rabbits, as well as its therapeutic potential and protective role 
      against staphylococcal infections in rabbit breeding.
CI  - (c) 2023. The Author(s).
FAU - Pogany Simonova, Monika
AU  - Pogany Simonova M
AUID- ORCID: 0000-0002-0377-4672
AD  - Centre of Biosciences of the Slovak Academy of Sciences, Institute of Animal 
      Physiology, Soltesovej 4-6, Kosice, 04001, Slovakia. simonova@saske.sk.
FAU - Chrastinova, Lubica
AU  - Chrastinova L
AD  - Department of Animal Nutrition, National Agricultural and Food Centre, Hlohovecka 
      2, Nitra-Luzianky, 95141, Slovakia.
FAU - Scerbova, Jana
AU  - Scerbova J
AUID- ORCID: 0000-0002-8704-3657
AD  - Centre of Biosciences of the Slovak Academy of Sciences, Institute of Animal 
      Physiology, Soltesovej 4-6, Kosice, 04001, Slovakia.
FAU - Fockova, Valentina
AU  - Fockova V
AUID- ORCID: 0000-0002-9113-3540
AD  - Centre of Biosciences of the Slovak Academy of Sciences, Institute of Animal 
      Physiology, Soltesovej 4-6, Kosice, 04001, Slovakia.
FAU - Placha, Iveta
AU  - Placha I
AUID- ORCID: 0000-0002-8724-0159
AD  - Centre of Biosciences of the Slovak Academy of Sciences, Institute of Animal 
      Physiology, Soltesovej 4-6, Kosice, 04001, Slovakia.
FAU - Tokarcikova, Katarina
AU  - Tokarcikova K
AUID- ORCID: 0000-0002-9117-7869
AD  - Centre of Biosciences of the Slovak Academy of Sciences, Institute of Animal 
      Physiology, Soltesovej 4-6, Kosice, 04001, Slovakia.
FAU - Zitnan, Rudolf
AU  - Zitnan R
AD  - Department of Animal Nutrition, National Agricultural and Food Centre, Hlohovecka 
      2, Nitra-Luzianky, 95141, Slovakia.
FAU - Laukova, Andrea
AU  - Laukova A
AUID- ORCID: 0000-0001-7413-3816
AD  - Centre of Biosciences of the Slovak Academy of Sciences, Institute of Animal 
      Physiology, Soltesovej 4-6, Kosice, 04001, Slovakia.
LA  - eng
PT  - Journal Article
DEP - 20231205
PL  - Switzerland
TA  - Vet Res Commun
JT  - Veterinary research communications
JID - 8100520
RN  - 0 (enterocin A)
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Bacteriocins)
RN  - GAN16C9B8O (Glutathione)
RN  - EC 1.11.1.- (Peroxidases)
RN  - 0 (Immunoglobulin A)
SB  - IM
EIN - Vet Res Commun. 2023 Dec 19;:. PMID: 38110730
MH  - Humans
MH  - Male
MH  - Female
MH  - Rabbits
MH  - Animals
MH  - *Methicillin-Resistant Staphylococcus aureus
MH  - Staphylococcus epidermidis
MH  - Methicillin Resistance
MH  - Anti-Bacterial Agents/pharmacology/therapeutic use
MH  - *Bacteriocins/pharmacology
MH  - *Staphylococcal Infections/drug therapy/veterinary/microbiology
MH  - Glutathione/pharmacology/therapeutic use
MH  - Peroxidases/pharmacology/therapeutic use
MH  - Immunoglobulin A/pharmacology/therapeutic use
PMC - PMC10810977
OTO - NOTNLM
OT  - Enterocin
OT  - Immunity
OT  - Jejunal morphometry
OT  - Methicillin-resistant Staphylococcus
OT  - Rabbits
COIS- The authors declare no competing interests.
EDAT- 2023/12/05 17:45
MHDA- 2024/01/26 06:43
PMCR- 2023/12/05
CRDT- 2023/12/05 11:10
PHST- 2023/09/05 00:00 [received]
PHST- 2023/12/02 00:00 [accepted]
PHST- 2024/01/26 06:43 [medline]
PHST- 2023/12/05 17:45 [pubmed]
PHST- 2023/12/05 11:10 [entrez]
PHST- 2023/12/05 00:00 [pmc-release]
AID - 10.1007/s11259-023-10277-w [pii]
AID - 10277 [pii]
AID - 10.1007/s11259-023-10277-w [doi]
PST - ppublish
SO  - Vet Res Commun. 2024 Feb;48(1):507-517. doi: 10.1007/s11259-023-10277-w. Epub 
      2023 Dec 5.