PMID- 38052425
OWN - NLM
STAT- MEDLINE
DCOM- 20240301
LR  - 20240301
IS  - 1439-4286 (Electronic)
IS  - 0018-5043 (Linking)
VI  - 56
IP  - 3
DP  - 2024 Mar
TI  - Association Between VEGF-460C/T Gene Polymorphism and Risk of Diabetic 
      Retinopathy in Type 2 Diabetes Mellitus: A Meta-Analysis.
PG  - 214-222
LID - 10.1055/a-2223-2790 [doi]
AB  - The aim of the study was to investigate the relationship between VEGF-460C/T 
      polymorphism and susceptibility to diabetic retinopathy (DR) in type 2 diabetes 
      mellitus (T2DM) by meta-analysis. A comprehensive search was conducted across six 
      databases until September 2023 to identify studies examining the association 
      between VEGF-460C/T polymorphism and susceptibility to DR. Data process was 
      performed by Stata 15.0 software. Eight studies were included, involving 1463 
      patients with DR. In the overall analysis, the difference was statistically 
      significant only in the homozygous model (CC vs. TT: OR=1.86, p=0.048). A 
      subgroup analysis of 6 papers with genotype frequency satisfying HWE in the 
      control group indicated significant differences among the allele (C vs. T: 
      OR=1.34, p=0.037), recessive (CC vs. CT+TT: OR=1.96, p=0.022) and homozygous (CC 
      vs. TT: OR=2.28, p=0.015) models. However, in the dominant and heterozygous 
      models, the difference was not statistically significant. The sensitivity of the 
      HWE-based subgroup analysis showed that the conclusions in other gene models 
      except the heterozygote model were not robust. This meta-analysis indicated that 
      VEGF-460C/T gene polymorphism is associated with susceptibility to DR in T2DM. 
      Allele C and genotype CC at the VEGF-460C/T locus are associated with an 
      increased risk of DR in T2DM. However, considering that the results are not 
      robust, more trials involving more rigorous design are needed to verify the 
      findings of this review in the future.
CI  - Thieme. All rights reserved.
FAU - Cheng, Bo
AU  - Cheng B
AUID- ORCID: 0009-0006-2477-9022
AD  - Department of Ophthalmology, The People's Hospital of Fenghua, Ningbo, China.
FAU - Wu, Aimin
AU  - Wu A
AD  - Department of Ophthalmology, The People's Hospital of Fenghua, Ningbo, China.
FAU - Zhou, Xuewei
AU  - Zhou X
AD  - Department of Ophthalmology, The People's Hospital of Fenghua, Ningbo, China.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
DEP - 20231205
PL  - Germany
TA  - Horm Metab Res
JT  - Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et 
      metabolisme
JID - 0177722
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - 0 (VEGFA protein, human)
SB  - IM
MH  - Humans
MH  - *Diabetes Mellitus, Type 2/complications/genetics
MH  - *Diabetic Retinopathy/genetics
MH  - Genetic Predisposition to Disease
MH  - Polymorphism, Single Nucleotide/genetics
MH  - Vascular Endothelial Growth Factor A/genetics
COIS- The authors declare that they have no conflict of interest.
EDAT- 2023/12/06 03:43
MHDA- 2024/03/01 06:43
CRDT- 2023/12/05 19:23
PHST- 2024/03/01 06:43 [medline]
PHST- 2023/12/06 03:43 [pubmed]
PHST- 2023/12/05 19:23 [entrez]
AID - 10.1055/a-2223-2790 [doi]
PST - ppublish
SO  - Horm Metab Res. 2024 Mar;56(3):214-222. doi: 10.1055/a-2223-2790. Epub 2023 Dec 
      5.