PMID- 38052615
OWN - NLM
STAT- MEDLINE
DCOM- 20231207
LR  - 20231216
IS  - 1551-0018 (Electronic)
IS  - 1547-1063 (Linking)
VI  - 20
IP  - 11
DP  - 2023 Oct 25
TI  - Aberrant intrinsic functional brain topology in methamphetamine-dependent 
      individuals after six-months of abstinence.
PG  - 19565-19583
LID - 10.3934/mbe.2023867 [doi]
AB  - Our aim was to explore the aberrant intrinsic functional topology in 
      methamphetamine-dependent individuals after six months of abstinence using 
      resting-state functional magnetic imaging (rs-fMRI). Eleven methamphetamines (MA) 
      abstainers who have abstained for six months and eleven healthy controls (HC) 
      were recruited for rs-fMRI examination. The graph theory and functional 
      connectivity (FC) analysis were employed to investigate the aberrant intrinsic 
      functional brain topology between the two groups at multiple levels. Compared 
      with the HC group, the characteristic shortest path length ($ L_p $) showed a 
      significant decrease at the global level, while the global efficiency ($ 
      E_glob $) and local efficiency ($ E_loc $) showed an increase 
      considerably. After FDR correction, we found significant group differences in 
      nodal degree and nodal efficiency at the regional level in the ventral 
      attentional network (VAN), dorsal attentional network (DAN), somatosensory 
      network (SMN), visual network (VN) and default mode network (DMN). In addition, 
      the NBS method presented the aberrations in edge-based FC, including 
      frontoparietal network (FPN), subcortical network (SCN), VAN, DAN, SMN, VN and 
      DMN. Moreover, the FC of large-scale functional brain networks revealed a 
      decrease within the VN and SCN and between the networks. These findings suggest 
      that some functions, e.g., visual processing skills, object recognition and 
      memory, may not fully recover after six months of withdrawal. This leads to the 
      possibility of relapse behavior when confronted with MA-related cues, which may 
      contribute to explaining the relapse mechanism. We also provide an imaging basis 
      for revealing the neural mechanism of MA-dependency after six months of 
      abstinence.
FAU - Li, Xiang
AU  - Li X
AD  - First Clinical Medical College, Shandong University of Traditional Chinese 
      Medicine, Jinan 250355, China.
AD  - Center for Medical Artificial Intelligence, Shandong University of Traditional 
      Chinese Medicine, Qingdao 266112, China.
AD  - Qingdao Academy of Chinese Medical Sciences, Shandong University of Traditional 
      Chinese Medicine, Qingdao 266112, China.
FAU - Cong, Jinyu
AU  - Cong J
AD  - Center for Medical Artificial Intelligence, Shandong University of Traditional 
      Chinese Medicine, Qingdao 266112, China.
AD  - Qingdao Academy of Chinese Medical Sciences, Shandong University of Traditional 
      Chinese Medicine, Qingdao 266112, China.
FAU - Liu, Kunmeng
AU  - Liu K
AD  - Center for Medical Artificial Intelligence, Shandong University of Traditional 
      Chinese Medicine, Qingdao 266112, China.
AD  - Qingdao Academy of Chinese Medical Sciences, Shandong University of Traditional 
      Chinese Medicine, Qingdao 266112, China.
FAU - Wang, Pingping
AU  - Wang P
AD  - Center for Medical Artificial Intelligence, Shandong University of Traditional 
      Chinese Medicine, Qingdao 266112, China.
AD  - Qingdao Academy of Chinese Medical Sciences, Shandong University of Traditional 
      Chinese Medicine, Qingdao 266112, China.
FAU - Sun, Min
AU  - Sun M
AD  - Shandong Detoxification Monitoring and Treatment Institute, Zibo 255311, China.
FAU - Wei, Benzheng
AU  - Wei B
AD  - Center for Medical Artificial Intelligence, Shandong University of Traditional 
      Chinese Medicine, Qingdao 266112, China.
AD  - Qingdao Academy of Chinese Medical Sciences, Shandong University of Traditional 
      Chinese Medicine, Qingdao 266112, China.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Math Biosci Eng
JT  - Mathematical biosciences and engineering : MBE
JID - 101197794
RN  - 44RAL3456C (Methamphetamine)
SB  - IM
MH  - Humans
MH  - *Methamphetamine
MH  - Brain Mapping/methods
MH  - Brain/diagnostic imaging
MH  - Visual Perception
MH  - Recurrence
OTO - NOTNLM
OT  - abstainers
OT  - functional connectivity
OT  - graph theory
OT  - mechanism
OT  - methamphetamine
EDAT- 2023/12/06 03:43
MHDA- 2023/12/07 12:42
CRDT- 2023/12/05 21:37
PHST- 2023/12/07 12:42 [medline]
PHST- 2023/12/06 03:43 [pubmed]
PHST- 2023/12/05 21:37 [entrez]
AID - 10.3934/mbe.2023867 [doi]
PST - ppublish
SO  - Math Biosci Eng. 2023 Oct 25;20(11):19565-19583. doi: 10.3934/mbe.2023867.