PMID- 38053348
OWN - NLM
STAT- MEDLINE
DCOM- 20231222
LR  - 20231222
IS  - 1944-8252 (Electronic)
IS  - 1944-8244 (Linking)
VI  - 15
IP  - 50
DP  - 2023 Dec 20
TI  - Enantioselective Antiviral Activities of Chiral Zinc Oxide Nanoparticles.
PG  - 58251-58259
LID - 10.1021/acsami.3c15463 [doi]
AB  - Chiral nanoparticles (C-NPs) play a crucial role in biomedical applications, 
      especially in their biological effects on cytotoxicity and metabolism. However, 
      there are rare reports about the antivirus property of C-NPs and their working 
      mechanism. Here, three different types of chiral ZnO NPs (l-ZnO, d-ZnO, and 
      dl-ZnO) were prepared as enantioselective antivirals. Biocompatibility test 
      results showed that the three different chiral ZnO NPs varied significantly in 
      cytotoxicity. Evaluation of their effects against porcine reproductive and 
      respiratory syndrome virus (PRRSV) indicated that compared with d-ZnO and dl-ZnO 
      NPs, l-ZnO NPs exhibited stronger anti-PRRSV activity due to their higher cognate 
      cell adhesion and uptake. Furthermore, the high concentration of l-ZnO NPs can 
      obviously reduce cellular reactive oxygen species (ROS) in MARC-145 cells, thus 
      effectively preventing PRRSV-induced oxidative damage. This study demonstrated 
      the outstanding antiviral properties of l-ZnO NPs, which may facilitate the 
      development and application of C-NPs in antiviral drugs and tissue engineering.
FAU - Fan, Xiaoxia
AU  - Fan X
AD  - State Key Laboratory of Agricultural Microbiology, College of Science, College of 
      Resource and Environment, Huazhong Agricultural University, Wuhan 430070, P. R. 
      China.
FAU - Ren, Caifeng
AU  - Ren C
AD  - State Key Laboratory of Agricultural Microbiology, College of Science, College of 
      Resource and Environment, Huazhong Agricultural University, Wuhan 430070, P. R. 
      China.
FAU - Ning, Keke
AU  - Ning K
AD  - State Key Laboratory of Agricultural Microbiology, College of Science, College of 
      Resource and Environment, Huazhong Agricultural University, Wuhan 430070, P. R. 
      China.
FAU - Shoala, Mohamed A
AU  - Shoala MA
AD  - State Key Laboratory of Agricultural Microbiology, College of Science, College of 
      Resource and Environment, Huazhong Agricultural University, Wuhan 430070, P. R. 
      China.
FAU - Ke, Qiyun
AU  - Ke Q
AD  - State Key Laboratory of Agricultural Microbiology, College of Veterinary 
      Medicine, Key Laboratory of Preventive Veterinary Medicine in Hubei Province, 
      Huazhong Agricultural University, Wuhan 430070, P. R. China.
FAU - Zhou, Yanrong
AU  - Zhou Y
AD  - State Key Laboratory of Agricultural Microbiology, College of Veterinary 
      Medicine, Key Laboratory of Preventive Veterinary Medicine in Hubei Province, 
      Huazhong Agricultural University, Wuhan 430070, P. R. China.
FAU - Wu, Yuan
AU  - Wu Y
AD  - State Key Laboratory of Agricultural Microbiology, College of Science, College of 
      Resource and Environment, Huazhong Agricultural University, Wuhan 430070, P. R. 
      China.
FAU - Qiu, Runhui
AU  - Qiu R
AD  - State Key Laboratory of Agricultural Microbiology, College of Veterinary 
      Medicine, Key Laboratory of Preventive Veterinary Medicine in Hubei Province, 
      Huazhong Agricultural University, Wuhan 430070, P. R. China.
FAU - Liang, Jiangong
AU  - Liang J
AUID- ORCID: 0000-0002-8210-0210
AD  - State Key Laboratory of Agricultural Microbiology, College of Science, College of 
      Resource and Environment, Huazhong Agricultural University, Wuhan 430070, P. R. 
      China.
FAU - Xiao, Shaobo
AU  - Xiao S
AUID- ORCID: 0000-0003-0023-9188
AD  - State Key Laboratory of Agricultural Microbiology, College of Veterinary 
      Medicine, Key Laboratory of Preventive Veterinary Medicine in Hubei Province, 
      Huazhong Agricultural University, Wuhan 430070, P. R. China.
LA  - eng
PT  - Journal Article
DEP - 20231206
PL  - United States
TA  - ACS Appl Mater Interfaces
JT  - ACS applied materials & interfaces
JID - 101504991
RN  - SOI2LOH54Z (Zinc Oxide)
RN  - 0 (Reactive Oxygen Species)
RN  - 0 (Antiviral Agents)
SB  - IM
MH  - *Zinc Oxide/pharmacology
MH  - Stereoisomerism
MH  - *Nanoparticles
MH  - Oxidative Stress
MH  - Reactive Oxygen Species/metabolism
MH  - Antiviral Agents/pharmacology
MH  - *Metal Nanoparticles
OTO - NOTNLM
OT  - antiviral
OT  - chiral nanoparticles
OT  - chiral zinc oxide
OT  - porcine reproductive and respiratory syndrome virus
OT  - reactive oxygen species
EDAT- 2023/12/06 06:42
MHDA- 2023/12/22 06:42
CRDT- 2023/12/06 03:38
PHST- 2023/12/22 06:42 [medline]
PHST- 2023/12/06 06:42 [pubmed]
PHST- 2023/12/06 03:38 [entrez]
AID - 10.1021/acsami.3c15463 [doi]
PST - ppublish
SO  - ACS Appl Mater Interfaces. 2023 Dec 20;15(50):58251-58259. doi: 
      10.1021/acsami.3c15463. Epub 2023 Dec 6.