PMID- 38054701 OWN - NLM STAT- MEDLINE DCOM- 20231207 LR - 20240210 IS - 1552-9924 (Electronic) IS - 0091-6765 (Print) IS - 0091-6765 (Linking) VI - 131 IP - 12 DP - 2023 Dec TI - Associations of Prenatal Per- and Polyfluoroalkyl Substance (PFAS) Exposures with Offspring Adiposity and Body Composition at 16-20 Years of Age: Project Viva. PG - 127002 LID - 10.1289/EHP12597 [doi] LID - 127002 AB - BACKGROUND: Findings on the associations between prenatal PFAS exposures and offspring adiposity are inconsistent. Whether such associations may extend to adolescence is especially understudied. OBJECTIVES: We investigated associations of prenatal PFAS exposures with offspring adiposity and body composition at 16-20 years of age. METHODS: We studied 545 mother-child pairs in the prospective prebirth cohort Project Viva (Boston, Massachusetts). We measured six PFAS (PFOA, PFOS, PFNA, PFHxS, EtFOSAA, and MeFOSAA) in maternal early pregnancy (median age = 9.6 wk, range: 5.7-19.6 wk) plasma samples. At the late adolescence visit (median age = 17.4 y, range: 15.9-20.0 y), we obtained anthropometric measures and assessed body composition using bioelectrical impedance analysis and dual-energy X-ray absorptiometry. We examined associations of individual PFAS with obesity [i.e., age- and sex-specific body mass index (BMI) >/= 95th percentile] and adiposity and body composition using multivariable Poisson and linear regression models, respectively. We assessed PFAS mixture effects using Bayesian kernel machine regression (BKMR) and quantile g-computation. We used fractional-polynomial models to assess BMI trajectories (at 3-20 years of age) by prenatal PFAS levels. RESULTS: Thirteen percent (n = 73) of the children had obesity in late adolescence. After multivariable adjustment, higher prenatal PFAS concentrations were associated with higher obesity risk [e.g., 1.59 (95% CI: 1.19, 2.12), 1.24 (95% CI: 0.98, 1.57), and 1.49 (95% CI: 1.11, 1.99) times the obesity risk per doubling of PFOS, PFOA, and PFNA, respectively]. BKMR showed an interaction between PFOA and PFOS, where the positive association between PFOS and obesity was stronger when PFOA levels were lower. Each quartile increment of the PFAS mixture was associated with 1.52 (95% CI: 1.03, 2.25) times the obesity risk and 0.52 (95% CI: - 0.02, 1.06) kg/m2 higher BMI. Children with higher prenatal PFOS, EtFOSAA, and MeFOSAA concentrations had higher rates of BMI increase starting from 9-11 years of age. DISCUSSION: Prenatal PFAS exposures may have obesogenic effects into late adolescence. https://doi.org/10.1289/EHP12597. FAU - Zhang, Mingyu AU - Zhang M AUID- ORCID: 0000-0003-3628-0983 AD - Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts, USA. AD - Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA. FAU - Rifas-Shiman, Sheryl L AU - Rifas-Shiman SL AUID- ORCID: 0000-0003-0033-920X AD - Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts, USA. FAU - Aris, Izzuddin M AU - Aris IM AUID- ORCID: 0000-0002-9239-7476 AD - Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts, USA. FAU - Fleisch, Abby F AU - Fleisch AF AUID- ORCID: 0000-0002-2789-6412 AD - Center for Interdisciplinary Population Health Research, MaineHealth Institute for Research, Portland, Maine, USA. AD - Pediatric Endocrinology and Diabetes, Maine Medical Center, Portland, Maine, USA. FAU - Lin, Pi-I Debby AU - Lin PD AUID- ORCID: 0000-0003-3564-4255 AD - Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts, USA. FAU - Nichols, Amy R AU - Nichols AR AUID- ORCID: 0000-0002-3085-7377 AD - Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts, USA. AD - Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA. FAU - Oken, Emily AU - Oken E AUID- ORCID: 0000-0003-2513-3339 AD - Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts, USA. AD - Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA. FAU - Hivert, Marie-France AU - Hivert MF AUID- ORCID: 0000-0001-7752-2585 AD - Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts, USA. AD - Diabetes Unit, Massachusetts General Hospital, Boston, Massachusetts, USA. LA - eng GR - R01 ES030101/ES/NIEHS NIH HHS/United States GR - R01 HD034568/HD/NICHD NIH HHS/United States GR - R24 ES030894/ES/NIEHS NIH HHS/United States GR - UG3 OD023286/OD/NIH HHS/United States PT - Journal Article DEP - 20231206 PL - United States TA - Environ Health Perspect JT - Environmental health perspectives JID - 0330411 RN - 0 (Fluorocarbons) RN - 0 (Alkanesulfonic Acids) RN - 0 (Environmental Pollutants) SB - IM MH - Male MH - Pregnancy MH - Female MH - Adolescent MH - Humans MH - Adiposity MH - Prospective Studies MH - Bayes Theorem MH - *Fluorocarbons MH - *Alkanesulfonic Acids MH - Obesity MH - Body Composition MH - *Environmental Pollutants PMC - PMC10699168 EDAT- 2023/12/06 12:42 MHDA- 2023/12/07 12:42 PMCR- 2023/12/06 CRDT- 2023/12/06 09:03 PHST- 2023/12/07 12:42 [medline] PHST- 2023/12/06 12:42 [pubmed] PHST- 2023/12/06 09:03 [entrez] PHST- 2023/12/06 00:00 [pmc-release] AID - EHP12597 [pii] AID - 10.1289/EHP12597 [doi] PST - ppublish SO - Environ Health Perspect. 2023 Dec;131(12):127002. doi: 10.1289/EHP12597. Epub 2023 Dec 6.