PMID- 38057124
OWN - NLM
STAT- MEDLINE
DCOM- 20231211
LR  - 20231211
IS  - 1476-4954 (Electronic)
IS  - 1476-4954 (Linking)
VI  - 36
IP  - 2
DP  - 2023 Dec
TI  - Evaluation of maternal-fetal outcomes in pregnancy complicated with severe 
      pulmonary hypertension and its influencing factors: a single-center retrospective 
      study in China.
PG  - 2290923
LID - 10.1080/14767058.2023.2290923 [doi]
AB  - OBJECTIVE: Pregnancy is not recommended for patients with severe pulmonary 
      hypertension (PH) due to the significant risks it poses to both the mother and 
      fetus. The objective of this study is to describe the maternal-fetal outcomes in 
      pregnant women with PH and identify the factors that influence these outcomes. 
      METHOD: This retrospective study analyzed clinical data from 25 patients with 
      severe PH who were admitted to our hospital between January 2018 and December 
      2022. The data we used came from a public general hospital in Fujian Province. 
      RESULTS: The mean systolic pulmonary artery pressure (sPAP) of 25 patients was 
      105.12 +/- 22.70 mmHg. All patients had received one or more multidisciplinary team 
      (MDT) treatments before terminating their pregnancies. Among the pregnant women, 
      four experienced a pulmonary hypertensive crisis (PHC), seven had heart failure, 
      and one had postpartum hemorrhage (PPH). Among them, seven (28%) pregnant women 
      died primarily due to heart failure and PHC. Among the fetal outcomes, twelve 
      resulted in therapeutic abortion, and eleven resulted in preterm birth. Among the 
      perinatal complications, eleven infants (84.6%) were born prematurely, six 
      infants (46.2%) experienced neonatal asphyxia, eight infants (61.5%) had low 
      birth weight, and two infants (15.4%) died during the perinatal period. According 
      to the etiology, seven individuals had idiopathic pulmonary arterial hypertension 
      (iPAH), ten had pulmonary arterial hypertension associated with congenital heart 
      disease (CHD-PAH), six had pulmonary hypertension associated with left heart 
      disease (LDH-PH), and two had pulmonary arterial hypertension caused by other 
      diseases (oPAH). The sPAP levels of iPAH and CHD-PAH were significantly higher 
      than those of LDH-PH and oPAH (p < 0.05). Additionally, the gestational weeks of 
      LDH-PH were higher than those of iPAH (p < 0.05). The number of patients with New 
      York Heart Association (NYHA) heart function grade III-V was higher in the death 
      group compared to the non-death group (p < 0.05). CONCLUSION: Pregnancy in women 
      with severe PH carries a high risk of mortality. Therefore, contraception is 
      strongly recommended for these women. NYHA cardiac function grade III-IV was 
      useful in predicting the risk of mortality.
FAU - Dai, Qiulan
AU  - Dai Q
AD  - Department of Obstetrics and Gynecology, Fujian Medical University Union 
      Hospital, Fuzhou, China.
FAU - Shang, Manman
AU  - Shang M
AD  - School of Public Health, Fujian Medical University, Fuzhou, China.
FAU - Zhou, Yu
AU  - Zhou Y
AD  - Department of Obstetrics and Gynecology, Fujian Medical University Union 
      Hospital, Fuzhou, China.
FAU - Wei, Qin
AU  - Wei Q
AD  - Department of Medical Administration, Fujian Medical University Union Hospital, 
      Fuzhou, China.
LA  - eng
PT  - Journal Article
DEP - 20231206
PL  - England
TA  - J Matern Fetal Neonatal Med
JT  - The journal of maternal-fetal & neonatal medicine : the official journal of the 
      European Association of Perinatal Medicine, the Federation of Asia and Oceania 
      Perinatal Societies, the International Society of Perinatal Obstetricians
JID - 101136916
SB  - IM
MH  - Infant
MH  - Female
MH  - Pregnancy
MH  - Infant, Newborn
MH  - Humans
MH  - *Hypertension, Pulmonary/etiology/complications
MH  - *Pulmonary Arterial Hypertension/complications
MH  - Retrospective Studies
MH  - Cesarean Section/adverse effects
MH  - *Premature Birth/epidemiology
MH  - Familial Primary Pulmonary Hypertension/complications
MH  - *Heart Defects, Congenital/complications
MH  - *Heart Failure
MH  - Parturition
MH  - Pregnancy Outcome/epidemiology
OTO - NOTNLM
OT  - Pregnancy
OT  - maternal-fetal outcome
OT  - multidisciplinary team
OT  - pulmonary hypertension
EDAT- 2023/12/07 00:42
MHDA- 2023/12/11 12:42
CRDT- 2023/12/06 21:13
PHST- 2023/12/11 12:42 [medline]
PHST- 2023/12/07 00:42 [pubmed]
PHST- 2023/12/06 21:13 [entrez]
AID - 10.1080/14767058.2023.2290923 [doi]
PST - ppublish
SO  - J Matern Fetal Neonatal Med. 2023 Dec;36(2):2290923. doi: 
      10.1080/14767058.2023.2290923. Epub 2023 Dec 6.