PMID- 38057389
OWN - NLM
STAT- MEDLINE
DCOM- 20240327
LR  - 20240328
IS  - 1432-5233 (Electronic)
IS  - 0940-5429 (Print)
IS  - 0940-5429 (Linking)
VI  - 61
IP  - 4
DP  - 2024 Apr
TI  - Alanine transferase levels (ALT) and triglyceride-glucose index are risk factors 
      for type 2 diabetes mellitus in obese patients.
PG  - 435-440
LID - 10.1007/s00592-023-02209-6 [doi]
AB  - AIMS: The role of liver steatosis and increased liver enzymes (ALT) in increasing 
      incident type 2 diabetes mellitus (T2DM) is debated, because of their 
      differential effects on different ethnicities and populations. The aim of this 
      study was to evaluate the role of elevated ALT in the development of T2DM in 
      non-diabetic obese subjects receiving routine medical treatment. METHODS: A total 
      of 1005 subjects [296 men and 709 women, aged 45.7 +/- 13.12 years, body mass index 
      (BMI) 39.5 +/- 4.86 kg/m(2)] were followed for a mean period of 14.3 +/- 4.44 years. 
      Subjects were evaluated for several metabolic variables, including the 
      triglyceride-glucose index and the presence of metabolic syndrome (IDF 2005 
      definition), and were subdivided into ALT quartiles. RESULTS: T2DM developed in 
      136 subjects, and the difference was significant between the first and the fourth 
      ALT quartile (p = 0.048). Both at univariate analysis and at stepwise regression, 
      ALT quartiles were associated with incident T2DM. Traditional risk factors for 
      T2DM coexisted, with a somehow greater predictive value, such as 
      triglyceride-glucose index, age, arterial hypertension, LDL-cholesterol, and 
      metabolic syndrome. CONCLUSIONS: These data suggest an association between 
      elevated ALT levels and the risk of incident T2DM in obesity.
CI  - (c) 2023. The Author(s).
FAU - Folli, Franco
AU  - Folli F
AUID- ORCID: 0000-0001-9824-5222
AD  - Dipartimento di Scienze della Salute, Universita degli Studi di Milano, Milan, 
      Italy. franco.folli@unimi.it.
FAU - Pontiroli, Antonio E
AU  - Pontiroli AE
AD  - Dipartimento di Scienze della Salute, Universita degli Studi di Milano, Milan, 
      Italy.
FAU - Zakaria, Ahmed S
AU  - Zakaria AS
AD  - Ospedale San Paolo, Milan, Italy.
FAU - Centofanti, Lucia
AU  - Centofanti L
AD  - Dipartimento di Scienze della Salute, Universita degli Studi di Milano, Milan, 
      Italy.
FAU - Tagliabue, Elena
AU  - Tagliabue E
AD  - Laboratory of Cardiovascular and Dysmetabolic Diseases, IRCCS MultiMedica, Milan, 
      Italy.
FAU - La Sala, Lucia
AU  - La Sala L
AD  - Laboratory of Cardiovascular and Dysmetabolic Diseases, IRCCS MultiMedica, Milan, 
      Italy.
LA  - eng
PT  - Journal Article
DEP - 20231206
PL  - Germany
TA  - Acta Diabetol
JT  - Acta diabetologica
JID - 9200299
RN  - 0 (Triglycerides)
RN  - IY9XDZ35W2 (Glucose)
RN  - EC 2.- (Transferases)
RN  - EC 2.6.1.2 (Alanine Transaminase)
RN  - OF5P57N2ZX (Alanine)
SB  - IM
MH  - Male
MH  - Humans
MH  - Female
MH  - *Diabetes Mellitus, Type 2/complications/epidemiology
MH  - *Metabolic Syndrome/complications/epidemiology
MH  - Triglycerides
MH  - Glucose
MH  - Transferases
MH  - Risk Factors
MH  - Obesity/complications
MH  - Body Mass Index
MH  - Alanine Transaminase
MH  - Alanine
PMC - PMC10963574
OTO - NOTNLM
OT  - Liver
OT  - Metabolic syndrome
OT  - Triglyceride-glucose index
OT  - Type 2 diabetes
COIS- The authors declare no conflict of interest.
EDAT- 2023/12/07 00:42
MHDA- 2024/03/27 06:43
PMCR- 2023/12/06
CRDT- 2023/12/06 23:29
PHST- 2023/09/07 00:00 [received]
PHST- 2023/11/07 00:00 [accepted]
PHST- 2024/03/27 06:43 [medline]
PHST- 2023/12/07 00:42 [pubmed]
PHST- 2023/12/06 23:29 [entrez]
PHST- 2023/12/06 00:00 [pmc-release]
AID - 10.1007/s00592-023-02209-6 [pii]
AID - 2209 [pii]
AID - 10.1007/s00592-023-02209-6 [doi]
PST - ppublish
SO  - Acta Diabetol. 2024 Apr;61(4):435-440. doi: 10.1007/s00592-023-02209-6. Epub 2023 
      Dec 6.