PMID- 38057480
OWN - NLM
STAT- MEDLINE
DCOM- 20231211
LR  - 20231222
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 13
IP  - 1
DP  - 2023 Dec 6
TI  - Association between brain cancer immunogenetic profile and in silico 
      immunogenicities of 11 viruses.
PG  - 21528
LID - 10.1038/s41598-023-48843-6 [doi]
LID - 21528
AB  - Several viruses including human herpes viruses (HHVs), human polyomavirus JCV, 
      and human papilloma virus (HPV) have been implicated in brain cancer, albeit 
      inconsistently. Since human leukocyte antigen (HLA) is centrally involved in the 
      human immune response to viruses and has been implicated in brain cancer, we 
      evaluated in silico the immunogenicity between 69 Class I HLA alleles with 
      epitopes of proteins of 9 HHVs, JCV, and HPV with respect to a population-based 
      HLA-brain cancer profile. We found that immunogenicity varied widely across HLA 
      alleles with HLA-C alleles exhibiting the highest immunogenicity, and that 
      immunogenicity scores were negatively associated with the population-based 
      HLA-brain cancer profile, particularly for JCV, HHV6A, HHV5, HHV3, HHV8, and 
      HHV7. Consistent with the role of HLA in foreign antigen elimination, the 
      findings suggest that viruses with proteins of high HLA immunogenicity are 
      eliminated more effectively and, consequently, less likely to cause brain cancer; 
      conversely, the absence of highly immunogenic HLA may allow the viral antigens to 
      persist, contributing to cancer.
CI  - (c) 2023. This is a U.S. Government work and not under copyright protection in the 
      US; foreign copyright protection may apply.
FAU - Georgopoulos, Apostolos P
AU  - Georgopoulos AP
AD  - The HLA Research Group, Brain Sciences Center, Department of Veterans Affairs 
      Health Care System, Minneapolis VAMC, One Veterans Drive, Minneapolis, MN, 55417, 
      USA. omega@umn.edu.
AD  - Department of Neuroscience, University of Minnesota Medical School, Minneapolis, 
      MN, USA. omega@umn.edu.
AD  - Department of Psychiatry, University of Minnesota Medical School, Minneapolis, 
      MN, USA. omega@umn.edu.
AD  - Department of Neurology, University of Minnesota Medical School, Minneapolis, MN, 
      USA. omega@umn.edu.
FAU - James, Lisa M
AU  - James LM
AD  - The HLA Research Group, Brain Sciences Center, Department of Veterans Affairs 
      Health Care System, Minneapolis VAMC, One Veterans Drive, Minneapolis, MN, 55417, 
      USA.
AD  - Department of Neuroscience, University of Minnesota Medical School, Minneapolis, 
      MN, USA.
AD  - Department of Psychiatry, University of Minnesota Medical School, Minneapolis, 
      MN, USA.
LA  - eng
PT  - Journal Article
DEP - 20231206
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (HLA Antigens)
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - Humans
MH  - *Papillomavirus Infections
MH  - Immunogenetics
MH  - Histocompatibility Antigens Class I/genetics
MH  - HLA Antigens/genetics
MH  - Histocompatibility Antigens Class II
MH  - *JC Virus/genetics
MH  - *Brain Neoplasms/genetics
MH  - Alleles
PMC - PMC10700375
COIS- The authors declare no competing interests.
EDAT- 2023/12/07 00:42
MHDA- 2023/12/11 12:43
PMCR- 2023/12/06
CRDT- 2023/12/06 23:39
PHST- 2023/07/27 00:00 [received]
PHST- 2023/11/30 00:00 [accepted]
PHST- 2023/12/11 12:43 [medline]
PHST- 2023/12/07 00:42 [pubmed]
PHST- 2023/12/06 23:39 [entrez]
PHST- 2023/12/06 00:00 [pmc-release]
AID - 10.1038/s41598-023-48843-6 [pii]
AID - 48843 [pii]
AID - 10.1038/s41598-023-48843-6 [doi]
PST - epublish
SO  - Sci Rep. 2023 Dec 6;13(1):21528. doi: 10.1038/s41598-023-48843-6.