PMID- 38058041
OWN - NLM
STAT- MEDLINE
DCOM- 20231218
LR  - 20231218
IS  - 0529-5807 (Print)
IS  - 0529-5807 (Linking)
VI  - 52
IP  - 12
DP  - 2023 Dec 8
TI  - [Primary pulmonary NUT carcinoma: a clinicopathological analysis of seven cases].
PG  - 1244-1248
LID - 10.3760/cma.j.cn112151-20230912-00165 [doi]
AB  - Objective: To investigate the clinicopathological characteristics of primary 
      pulmonary NUT carcinoma. Methods: A total of 7 cases of primary pulmonary NUT 
      carcinoma were collected from Fujian Provincial Hospital (n=5), Fuzhou Taijiang 
      Hospital (n=1) and Binzhou City People's Hospital of Shandong Province (n=1) from 
      January 2021 to April 2023. The clinical, histopathological, and 
      immunohistochemical features were analyzed, and NUT rearrangement were detected 
      by fluorescence in situ hybridization (FISH) with break-apart probes. Results: 
      Seven cases were all male with age ranging from 32 to 73 years. The main clinical 
      manifestations were cough, expectoration and chest tightness. Microscopically, 
      NUT carcinoma was composed of monotonous proliferation of primitive-appearing 
      small-to-medium round cells, with few eosinophilic cytoplasm, arranged in solid 
      sheets, nests or clusters. Abrupt keratinization was typically observed in 4 
      cases (4/7), with high mitotic activities and necrosis. Immunohistochemistry 
      (IHC) showed that the tumors were positive for NUT (7/7), CK7 (4/4), CK5/6 (5/6), 
      p40 (6/7). Ki-67 index were 30%-80%. NUT gene segregation (7/7) was detected by 
      FISH break probes. Conclusions: Primary pulmonary NUT carcinoma is rare and 
      highly malignant. Diagnosis depends on histopathology and IHC, with molecular 
      detection as an adjunct for diagnosis. Pathologists should be aware of the 
      clinicopathological characteristics to avoid misdiagnosis.
FAU - Zhuang, X P
AU  - Zhuang XP
AD  - Department of Pathology, Shengli Clinical Medical College of Fujian Medical 
      University/Fujian Provincial Hospital, Fuzhou 350001, China.
FAU - Huang, H J
AU  - Huang HJ
AD  - Department of Pathology, Shengli Clinical Medical College of Fujian Medical 
      University/Fujian Provincial Hospital, Fuzhou 350001, China.
FAU - Chen, X
AU  - Chen X
AD  - Department of Pathology, Shengli Clinical Medical College of Fujian Medical 
      University/Fujian Provincial Hospital, Fuzhou 350001, China.
FAU - Zheng, S L
AU  - Zheng SL
AD  - Department of Pathology, Fuzhou Taijiang Hospital, Fuzhou 350001, China.
FAU - Li, B C
AU  - Li BC
AD  - Department of Pathology, Binzhou City People's Hospital of Shandong Province, 
      Binzhou 256610, China.
FAU - Sun, H
AU  - Sun H
AD  - Department of Pathology, Xiapu Hospital of Fujian Province, Ningde 355100, China.
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Bing Li Xue Za Zhi
JT  - Zhonghua bing li xue za zhi = Chinese journal of pathology
JID - 0005331
RN  - 0 (Neoplasm Proteins)
RN  - 0 (NUTM1 protein, human)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Carcinoma/genetics/pathology
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - *Lung Neoplasms/pathology
MH  - Neoplasm Proteins/genetics
EDAT- 2023/12/07 06:42
MHDA- 2023/12/11 12:41
CRDT- 2023/12/07 01:06
PHST- 2023/12/11 12:41 [medline]
PHST- 2023/12/07 06:42 [pubmed]
PHST- 2023/12/07 01:06 [entrez]
AID - 10.3760/cma.j.cn112151-20230912-00165 [doi]
PST - ppublish
SO  - Zhonghua Bing Li Xue Za Zhi. 2023 Dec 8;52(12):1244-1248. doi: 
      10.3760/cma.j.cn112151-20230912-00165.