PMID- 38058194
OWN - NLM
STAT- Publisher
LR  - 20231207
IS  - 1804-7521 (Electronic)
IS  - 1213-8118 (Linking)
DP  - 2023 Dec 6
TI  - Levels of retinol and retinoic acid in pancreatic cancer, type-2 diabetes and 
      chronic pancreatitis.
LID - 10.5507/bp.2023.049 [doi]
AB  - AIMS: Retinoids participate in multiple key processes in the human body e.g., 
      vision, cell differentiation and embryonic development. There is growing evidence 
      of the relationship between retinol, its active metabolite- all-trans retinoic 
      acid (ATRA) - and several pancreatic disorders. Although low levels of ATRA in 
      pancreatic ductal adenocarcinoma (PDAC) tissue have been reported, data on serum 
      levels of ATRA in PDAC is still limited. The aim of our work was to determine 
      serum concentrations of retinol and ATRA in patients with PDAC, type-2 diabetes 
      mellitus (T2DM), chronic pancreatitis (CHP) and healthy controls. METHODS: High 
      performance liquid chromatography with UV detection (HPLC) was used to measure 
      serum levels of retinol and ATRA in 246 patients with different stages of PDAC, 
      T2DM, CHP and healthy controls. RESULTS: We found a significant decrease in the 
      retinol concentration in PDAC (0.44(+/-0.18) mg/L) compared to T2DM 
      (0.65(+/-0.19) mg/L, P<0.001), CHP (0.60(+/-0.18) mg/L, P< 0.001) and healthy 
      controls (0.61(+/-0.15) mg/L, P<0.001), significant decrease of ATRA levels in 
      PDAC (1.14(+/-0.49) ug/L) compared to T2DM (1.37(+/-0.56) ug/L, P<0.001) and 
      healthy controls(1.43(+/-0.55) ug/L, P<0.001). Differences between early stages 
      (I+II) of PDAC and non-carcinoma groups were not significant. We describe 
      correlations between retinol, prealbumin and transferrin, and correlation of ATRA 
      and IGFBP-2. CONCLUSION: Significant decrease in retinol and ATRA levels in PDAC 
      compared to T2DM, healthy individuals and/or CHP supports existing evidence of 
      the role of retinoids in PDAC. However, neither ATRA nor retinol are suitable for 
      detection of early PDAC. Correlation of ATRA levels and IGFBP-2 provides new 
      information about a possible IGF and retinol relationship.
FAU - Hrabak, Pavel
AU  - Hrabak P
AD  - Fourth Department of Internal Medicine, First Faculty of Medicine, Charles 
      University and General University Hospital in Prague, Prague, Czech Republic.
FAU - Zelenkova, Miroslava
AU  - Zelenkova M
AD  - Institute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of 
      Medicine, Charles University and General University Hospital in Prague, Czech 
      Republic.
FAU - Krechler, Tomas
AU  - Krechler T
AD  - Fourth Department of Internal Medicine, First Faculty of Medicine, Charles 
      University and General University Hospital in Prague, Prague, Czech Republic.
FAU - Soupal, Jan
AU  - Soupal J
AD  - 3rd Department of Medicine - Department of Endocrinology and Metabolism, First 
      Faculty of Medicine, Charles University and General University Hospital in 
      Prague, Prague, Czech Republic.
FAU - Vocka, Michal
AU  - Vocka M
AD  - Department of Oncology, First Faculty of Medicine, Charles University and General 
      University Hospital in Prague, Czech Republic.
FAU - Hanus, Tomas
AU  - Hanus T
AD  - Department of Urology, First Faculty of Medicine, Charles University and General 
      University Hospital in Prague, Czech Republic.
FAU - Petruzelka, Lubos
AU  - Petruzelka L
AD  - Department of Oncology, First Faculty of Medicine, Charles University and General 
      University Hospital in Prague, Czech Republic.
FAU - Svacina, Stepan
AU  - Svacina S
AD  - 3rd Department of Medicine - Department of Endocrinology and Metabolism, First 
      Faculty of Medicine, Charles University and General University Hospital in 
      Prague, Prague, Czech Republic.
FAU - Zak, Ales
AU  - Zak A
AD  - Fourth Department of Internal Medicine, First Faculty of Medicine, Charles 
      University and General University Hospital in Prague, Prague, Czech Republic.
FAU - Zima, Tomas
AU  - Zima T
AD  - Institute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of 
      Medicine, Charles University and General University Hospital in Prague, Czech 
      Republic.
FAU - Kalousova, Marta
AU  - Kalousova M
AD  - Institute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of 
      Medicine, Charles University and General University Hospital in Prague, Czech 
      Republic.
LA  - eng
PT  - Journal Article
DEP - 20231206
PL  - Czech Republic
TA  - Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub
JT  - Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, 
      Czechoslovakia
JID - 101140142
SB  - IM
OTO - NOTNLM
OT  - all-trans-retinoic-acid
OT  - chronic pancreatitis
OT  - pancreatic ductal adenocarcinoma
OT  - type-2 diabetes mellitus
OT  - vitamin A
COIS- The authors report no conflicts of interest in this work.
EDAT- 2023/12/07 06:42
MHDA- 2023/12/07 06:42
CRDT- 2023/12/07 03:42
PHST- 2023/12/07 06:42 [medline]
PHST- 2023/12/07 06:42 [pubmed]
PHST- 2023/12/07 03:42 [entrez]
AID - 10.5507/bp.2023.049 [doi]
PST - aheadofprint
SO  - Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2023 Dec 6. doi: 
      10.5507/bp.2023.049.