PMID- 38058671
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231208
IS  - 0970-9371 (Print)
IS  - 0974-5165 (Electronic)
IS  - 0970-9371 (Linking)
VI  - 40
IP  - 4
DP  - 2023 Oct-Dec
TI  - MASC Gets UNMASKED: Visiting a Rare Tumor with Emphasis on Cytomorphological 
      Features.
PG  - 192-199
LID - 10.4103/joc.joc_155_22 [doi]
AB  - BACKGROUND: Secretory carcinoma (SC) is a newly described entity which has been 
      often misdiagnosed earlier as acinic cell carcinoma on cytology. Diagnosing SC 
      was initially based upon identifying the ETV6:NTRK3 fusion gene with the help of 
      fluorescence in situ hybridization (FISH). Lately, with more knowledge of the 
      reliable histomorphology, cytology, and immunohistochemistry features, definitive 
      diagnosis can be confidently made without the help of FISH in almost every case. 
      MATERIALS AND METHODS: Six histologically confirmed cases of SC were studied. The 
      cytology slides of all the six cases were retrieved and reviewed to identify the 
      characteristic features which could have helped in raising the possibility of SC 
      on fine needle aspiration cytology itself. Cell blocks were also studied, 
      wherever available. RESULTS: Patients were all male with average age of 35.2 
      years. The six cases in the current study demonstrated at least focal cytoplasmic 
      vacuolization of varying sizes, papillae formations, and bland nuclear features 
      on fine needle aspirate smears. It was also seen that S-100 and mammaglobin 
      immunohistochemistry (IHC) are very helpful in confirming the diagnosis. 
      CONCLUSIONS: The results of the current study highlight the cytomorphological 
      features which may help in clinching the diagnosis SC on cytology itself. They 
      also highlight certain cytological features which help to rule out the other 
      differential diagnoses.
CI  - Copyright: (c) 2023 Journal of Cytology.
FAU - Anthony, Michael L
AU  - Anthony ML
AD  - Department of Pathology, Andhra Medical College, Vishakhapatnam, Andhra Pradesh, 
      India.
FAU - Kumari, Neha
AU  - Kumari N
AD  - Department of Pathology, Dr. B R Ambedkar State Institute of Medical Sciences 
      S.A.S Nagar Mohali, Punjab, India.
FAU - Jeladharan, Reshma
AU  - Jeladharan R
AD  - Amrita Institute of Medical Sciences, Amrita Vishwa Vidyapeetham, Kochi, Kerala, 
      India.
FAU - Gowda, Vinay N
AU  - Gowda VN
AD  - Department of Pathology, AIIMS, Jodhpur, Rajasthan, India.
FAU - Joshi, Prashant Pranesh
AU  - Joshi PP
AD  - Department of Pathology, AIIMS Manglagiri, Andhra Pradesh, India.
FAU - Durgapal, Prashant
AU  - Durgapal P
AD  - Department of Pathology, AIIMS, Rishikesh, Uttarakhand, India.
FAU - Kumar, Arvind
AU  - Kumar A
AD  - Department of Pathology, AIIMS, Rishikesh, Uttarakhand, India.
FAU - Singh, Ashok
AU  - Singh A
AD  - Department of Pathology, AIIMS, Rishikesh, Uttarakhand, India.
LA  - eng
PT  - Journal Article
DEP - 20231016
PL  - India
TA  - J Cytol
JT  - Journal of cytology
JID - 8915204
PMC - PMC10697318
OTO - NOTNLM
OT  - Histological-cytological correlation
OT  - IHC
OT  - parotid gland
OT  - salivary gland cytology
OT  - secretory carcinoma
COIS- There are no conflicts of interest.
EDAT- 2023/12/07 06:42
MHDA- 2023/12/07 06:43
PMCR- 2023/10/01
CRDT- 2023/12/07 04:08
PHST- 2022/11/09 00:00 [received]
PHST- 2023/05/24 00:00 [revised]
PHST- 2023/08/16 00:00 [accepted]
PHST- 2023/12/07 06:43 [medline]
PHST- 2023/12/07 06:42 [pubmed]
PHST- 2023/12/07 04:08 [entrez]
PHST- 2023/10/01 00:00 [pmc-release]
AID - JCytol-40-192 [pii]
AID - 10.4103/joc.joc_155_22 [doi]
PST - ppublish
SO  - J Cytol. 2023 Oct-Dec;40(4):192-199. doi: 10.4103/joc.joc_155_22. Epub 2023 Oct 
      16.