PMID- 38060717
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231207
IS  - 2168-8184 (Print)
IS  - 2168-8184 (Electronic)
IS  - 2168-8184 (Linking)
VI  - 15
IP  - 11
DP  - 2023 Nov
TI  - Intradermal Immunoglobulin E (IgE) Injection in a Specific Interval With 
      Emollient in the Control of Chronic Idiopathic Urticaria and Allergic Rhinitis.
PG  - e48358
LID - 10.7759/cureus.48358 [doi]
LID - e48358
AB  - Background and objective: Urticaria is distinguished by the activation of mast 
      cells and basophils via degranulation, predominantly induced by the cross-linkage 
      of allergens with specific immunoglobulin E (IgE) antibodies. Several hypotheses 
      propose that intradermal injections of IgE stimulate the production of antibodies 
      that are specifically targeted towards the histamine/immunoglobulin complex. 
      Subsequently, these antibodies exhibit binding affinity towards and exert 
      inhibitory effects on the generation of histamine during the occurrence of 
      allergic responses. The administration of many histaglobulin injections results 
      in an increase in the concentration of these specific antibodies. Consequently, 
      the present study was devised to assess the effectiveness of intradermal IgE 
      injection in conjunction with an emollient for managing chronic idiopathic 
      urticaria and allergic rhinitis at varying time intervals. Methods: This study 
      employed a cross-sectional design and included a sample of 104 participants. The 
      sample was divided into two groups: persons diagnosed with chronic idiopathic 
      urticaria (n=54) and individuals diagnosed with both allergic rhinitis and 
      chronic urticaria (n=50). A 1 ml intradermal IgE injection was provided on a 
      weekly basis over a duration of six months. A total of 49 patients were treated 
      with intradermal IgE injection alone, while 93 patients were treated with 
      intradermal IgE injection combined with emollient application. The evaluation of 
      the treatment's efficacy involved the utilization of the urticaria activity score 
      (UAS) for chronic urticaria, as well as the assessment of symptomatic improvement 
      in cases of allergic rhinitis. The weekly examination was conducted over a span 
      of three consecutive weeks, followed by subsequent evaluations after four, 12, 
      and 24 weeks of attendance, culminating in the final assessment. Results: Within 
      the sample of 104 participants, a substantial majority of 93 individuals 
      exhibited good outcomes in the management of their condition with the utilization 
      of emollients, whereas a minority of 11 patients experienced inadequate control. 
      In contrast, a group of 49 participants had a therapy regimen that did not 
      include the application of emollients, while another group of 55 persons 
      displayed symptoms that were not effectively managed. Based on recent research 
      findings, a noticeable decrease in symptoms of modest magnitude was observed by 
      the end of the third month. Furthermore, it is important to note that all 
      symptoms were successfully alleviated during a six-month therapeutic regimen, but 
      there was a minor residual dissatisfaction with the impairment of the sense of 
      smell.  Conclusion: Following the administration of six intradermal IgE 
      injections, a significant improvement in symptoms was observed in over 97% of 
      patients, regardless of whether their IgE levels remained unaltered, decreased, 
      or rose.
CI  - Copyright (c) 2023, Sumi et al.
FAU - Sumi, Farhana Rashid
AU  - Sumi FR
AD  - Department of Dermatology, City Medical College and Hospital, Gazipur, BGD.
FAU - Bhuiyan, Md Abul Kalam A
AU  - Bhuiyan MAKA
AD  - Department of Otolaryngology, City Medical College and Hospital, Gazipur, BGD.
FAU - Mukit, Md Abdul
AU  - Mukit MA
AD  - Department of Otolaryngology, City Medical College and Hospital, Gazipur, BGD.
FAU - Shamim, Sarker Mahbub A
AU  - Shamim SMA
AD  - Department of Dermatology and Venereology, MH Samorita Hospital and Medical 
      College, Dhaka, BGD.
FAU - Tabassum Orthy, Rehnuma
AU  - Tabassum Orthy R
AD  - Department of Dermatology, City Medical College and Hospital, Gazipur, BGD.
FAU - Jesmin, Saimun
AU  - Jesmin S
AD  - Department of Dermatology and Venereology, Dhaka Dermatology Institute, Dhaka, 
      BGD.
LA  - eng
PT  - Journal Article
DEP - 20231106
PL  - United States
TA  - Cureus
JT  - Cureus
JID - 101596737
PMC - PMC10698291
OTO - NOTNLM
OT  - allergic rhinitis
OT  - chronic idiopathic urticaria
OT  - dermatology
OT  - emollient
OT  - intradermal ige injection
COIS- The authors have declared that no competing interests exist.
EDAT- 2023/12/07 18:42
MHDA- 2023/12/07 18:43
PMCR- 2023/11/06
CRDT- 2023/12/07 14:44
PHST- 2023/09/04 00:00 [received]
PHST- 2023/11/05 00:00 [accepted]
PHST- 2023/12/07 18:43 [medline]
PHST- 2023/12/07 18:42 [pubmed]
PHST- 2023/12/07 14:44 [entrez]
PHST- 2023/11/06 00:00 [pmc-release]
AID - 10.7759/cureus.48358 [doi]
PST - epublish
SO  - Cureus. 2023 Nov 6;15(11):e48358. doi: 10.7759/cureus.48358. eCollection 2023 
      Nov.