PMID- 38060978 OWN - NLM STAT- MEDLINE DCOM- 20240318 LR - 20240318 IS - 1365-2133 (Electronic) IS - 0007-0963 (Print) IS - 0007-0963 (Linking) VI - 190 IP - 4 DP - 2024 Mar 15 TI - Atopic dermatitis, cognitive function and psychiatric comorbidities across early childhood and adolescence in a population-based UK birth cohort. PG - 501-509 LID - 10.1093/bjd/ljad486 [doi] AB - BACKGROUND: Atopic dermatitis (AD) may affect cognitive function, but studies are limited and inconsistent. The effect of AD severity on cognition remains underexplored and few previous studies have examined clinically validated or repeated measures of cognition throughout childhood. OBJECTIVES: To evaluate the relationship of AD activity and severity with validated measures of general cognition in a longitudinal birth cohort. METHODS: We conducted cross-sectional analyses using data from the Avon Longitudinal Study of Parents and Children (ALSPAC), a UK cohort of 14 975 individuals followed prospectively since their birth in 1991-92. AD was assessed 11 times between the age of 6 and 166 months. Mothers were asked if their child had an 'itchy, dry skin rash in the joints and creases', and AD status was time-updated accordingly as 'never', 'maybe', 'inactive', 'active/mild' or 'active/moderate-severe'. General cognition [i.e. intelligence quotient (IQ)] was measured at 18, 49, 103 and 186 months of age using the Griffiths Mental Development Scales (GMDS), Wechsler Preschool and Primary Scale of Intelligence (WPPSI), Wechsler Intelligence Scale for Children (WISC) and Wechsler Abbreviated Scale of Intelligence (WASI), respectively. Multivariable linear regression was used to compare IQ with respect to nearest time-updated AD status. Secondary analyses were stratified by the presence or absence of psychiatric or learning disorders. An exploratory longitudinal analysis of IQ across all four outcome assessments was conducted using generalized estimating equations. RESULTS: No significant associations between AD status and full-scale IQ scores on the GMDS, WPPSI, WISC and WASI were observed after adjustment for sociodemographic factors, atopic comorbidities and sleep characteristics. However, at 8 years of age, WISC Performance IQ was slightly, although statistically significantly, lower among children with active/moderate-severe AD [beta coefficient -2.16, 95% confidence interval (CI) -4.12 to -0.19] and Verbal IQ was slightly, but statistically significantly, higher among those with inactive AD (beta coefficient 1.31, 95% CI 0.28-2.34) compared with those without AD. Analyses stratified by psychiatric or learning disorders, and exploratory longitudinal analyses of cognition revealed similar findings. CONCLUSIONS: We did not find any clinically meaningful associations between AD activity and severity and general cognitive function during early childhood and adolescence. Future studies should incorporate objective measures of AD severity and investigate outcomes beyond IQ. CI - (c) The Author(s) 2023. Published by Oxford University Press on behalf of British Association of Dermatologists. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. FAU - Sockler, Patrick G AU - Sockler PG AUID- ORCID: 0000-0003-2569-9447 AD - Departments of Dermatology. AD - Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA. FAU - Hooper, Stephen R AU - Hooper SR AD - Department of Health Sciences, School of Medicine, University of North Carolina-Chapel Hill, Chapel Hill, NC, USA. FAU - Abuabara, Katrina AU - Abuabara K AD - Department of Dermatology, University of California-San Francisco School of Medicine, San Francisco, CA, USA. FAU - Ma, Emily Z AU - Ma EZ AD - University of Maryland School of Medicine, Baltimore, MD, USA. FAU - Radtke, Sarah AU - Radtke S AD - Child and Adolescent Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA. FAU - Bao, Aaron AU - Bao A AD - Departments of Dermatology. FAU - Kim, Elle AU - Kim E AD - Departments of Dermatology. AD - Departments of Biostatistics. FAU - Musci, Rashelle J AU - Musci RJ AD - Mental Health. FAU - Kartawira, Karin AU - Kartawira K AD - Departments of Dermatology. FAU - Wan, Joy AU - Wan J AUID- ORCID: 0000-0002-0189-0442 AD - Departments of Dermatology. AD - Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA. LA - eng GR - MC_PC_19009/MRC_/Medical Research Council/United Kingdom GR - MC_PC_15018/MRC_/Medical Research Council/United Kingdom GR - G9815508/MRC_/Medical Research Council/United Kingdom GR - WT_/Wellcome Trust/United Kingdom GR - K23 AR077629/AR/NIAMS NIH HHS/United States GR - K23AR077629/NH/NIH HHS/United States PT - Journal Article PL - England TA - Br J Dermatol JT - The British journal of dermatology JID - 0004041 SB - IM CIN - Br J Dermatol. 2024 Mar 15;190(4):e41. PMID: 38488649 MH - Child MH - Female MH - Humans MH - Child, Preschool MH - Adolescent MH - Longitudinal Studies MH - *Dermatitis, Atopic/epidemiology/psychology MH - Birth Cohort MH - Cross-Sectional Studies MH - Cognition MH - *Learning Disabilities MH - United Kingdom/epidemiology PMC - PMC10941325 MID - NIHMS1965390 COIS- J.W. has received research and fellowship funding (paid to her institution) from Pfizer and has served as an advisor to Janssen and Sun Pharmaceuticals (DMC), receiving honoraria. K.A. has received consulting fees from TARGET RWE and grants (paid to her institution) from Pfizer and Cosmetique Internacional SNC. The other authors declare no conflicts of interest. EDAT- 2023/12/07 18:42 MHDA- 2024/03/18 06:43 PMCR- 2024/12/07 CRDT- 2023/12/07 16:22 PHST- 2023/07/03 00:00 [received] PHST- 2023/10/27 00:00 [revised] PHST- 2023/12/01 00:00 [accepted] PHST- 2024/12/07 00:00 [pmc-release] PHST- 2024/03/18 06:43 [medline] PHST- 2023/12/07 18:42 [pubmed] PHST- 2023/12/07 16:22 [entrez] AID - 7462197 [pii] AID - ljad486 [pii] AID - 10.1093/bjd/ljad486 [doi] PST - ppublish SO - Br J Dermatol. 2024 Mar 15;190(4):501-509. doi: 10.1093/bjd/ljad486.