PMID- 38061246
OWN - NLM
STAT- MEDLINE
DCOM- 20240222
LR  - 20240222
IS  - 1873-6750 (Electronic)
IS  - 0160-4120 (Linking)
VI  - 183
DP  - 2024 Jan
TI  - The association between prenatal per-and polyfluoroalkyl substance levels and 
      Kawasaki disease among children of up to 4 years of age: A prospective birth 
      cohort of the Japan Environment and Children's study.
PG  - 108321
LID - S0160-4120(23)00594-9 [pii]
LID - 10.1016/j.envint.2023.108321 [doi]
AB  - Kawasaki disease (KD) is common among pediatric patients and is associated with 
      an increased risk of later cardiovascular complications, though the precise 
      pathophysiology of KD remains unknown. Per- and polyfluoroalkyl substances (PFAS) 
      have gathered notoriety as the causal pathogens of numerous diseases as well as 
      for their immunosuppressive effects. The present epidemiological study aims to 
      assess whether PFAS may affect KD risk. We evaluated research participants 
      included in the ongoing prospective nationwide birth cohort of the Japan 
      Environment and Children's Study (JECS). Among the over 100,000 pregnant women 
      enrolled in the JECS study, 28 types of PFAS were measured in pregnancy in a 
      subset of participants (N = 25,040). The JECS followed their children born 
      between 2011 and 2014 (n total infants = 25,256; n Kawasaki disease 
      infants = 271), up to age four. Among the 28 types of PFAS, those which were 
      detected in >60 % of participants at levels above the method reporting limit 
      (MRL) were eligible for analyses. Multivariable logistic regressions were 
      implemented on the seven eligible PFAS, adjusting for multiple comparison 
      effects. Finally, we conducted Weighted Quantile Sum (WQS) and Bayesian kernel 
      machine regression (BKMR) to assess the effects of the PFAS mixture on KD. 
      Therefore, we ran the BKMR model using kernel mechanical regression equations to 
      examine PFAS exposure and the outcomes of KD. Upon analysis, the adjusted 
      multivariable regression results did not reach statistical significance for the 
      seven eligible substances on KD, while odds ratios were all under 1.0. WQS 
      regression was used to estimate the mixture effect of the seven eligible PFAS, 
      revealing a negative correlation with KD incidence; similarly, BKMR implied an 
      inverse association between the PFAS mixture effect and KD incidence. In 
      conclusion, PFAS exposure was not associated with increased KD incidence.
CI  - Copyright (c) 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.
FAU - Iwata, Hiroyoshi
AU  - Iwata H
AD  - Center for Environmental and Health Sciences, Hokkaido University, North-12, 
      West-7, Kita-ku, Sapporo 060-0812, Japan.
FAU - Kobayashi, Sumitaka
AU  - Kobayashi S
AD  - Center for Environmental and Health Sciences, Hokkaido University, North-12, 
      West-7, Kita-ku, Sapporo 060-0812, Japan; Division of Epidemiological Research 
      for Chemical Disorders, Research Center for Chemical Information and Management, 
      National Institute of Occupational Safety and Health, 6-21-1, Nagao, Tama-ku, 
      Kawasaki 214-8585, Japan.
FAU - Itoh, Mariko
AU  - Itoh M
AD  - Center for Environmental and Health Sciences, Hokkaido University, North-12, 
      West-7, Kita-ku, Sapporo 060-0812, Japan.
FAU - Itoh, Sachiko
AU  - Itoh S
AD  - Center for Environmental and Health Sciences, Hokkaido University, North-12, 
      West-7, Kita-ku, Sapporo 060-0812, Japan.
FAU - Mesfin Ketema, Rahel
AU  - Mesfin Ketema R
AD  - Center for Environmental and Health Sciences, Hokkaido University, North-12, 
      West-7, Kita-ku, Sapporo 060-0812, Japan; Faculty of Health Sciences, Hokkaido 
      University, North-12, West-5, Kita-ku, Sapporo 060-0812, Japan.
FAU - Tamura, Naomi
AU  - Tamura N
AD  - Center for Environmental and Health Sciences, Hokkaido University, North-12, 
      West-7, Kita-ku, Sapporo 060-0812, Japan.
FAU - Miyashita, Chihiro
AU  - Miyashita C
AD  - Center for Environmental and Health Sciences, Hokkaido University, North-12, 
      West-7, Kita-ku, Sapporo 060-0812, Japan.
FAU - Yamaguchi, Takeshi
AU  - Yamaguchi T
AD  - Center for Environmental and Health Sciences, Hokkaido University, North-12, 
      West-7, Kita-ku, Sapporo 060-0812, Japan.
FAU - Yamazaki, Keiko
AU  - Yamazaki K
AD  - Center for Environmental and Health Sciences, Hokkaido University, North-12, 
      West-7, Kita-ku, Sapporo 060-0812, Japan.
FAU - Masuda, Hideyuki
AU  - Masuda H
AD  - Pharmaceutical Sciences, Musashino University, 1-1-20 Shinmachi, Nishitokyo, 
      Tokyo 202-8585, Japan.
FAU - Ait Bamai, Yu
AU  - Ait Bamai Y
AD  - Center for Environmental and Health Sciences, Hokkaido University, North-12, 
      West-7, Kita-ku, Sapporo 060-0812, Japan; Department of Pharmaceutical Sciences, 
      University of Antwerp, University Square 1, 2610 Wilrijk, Belgium.
FAU - Saijo, Yasuaki
AU  - Saijo Y
AD  - Division of Public Health and Epidemiology, Department of Social Medicine, 
      Asahikawa Medical University, 1-1-1 Midorigaoka-higashi-2-jo, Asahikawa 078-8510, 
      Japan.
FAU - Ito, Yoshiya
AU  - Ito Y
AD  - Faculty of Nursing, Japanese Red Cross Hokkaido College of Nursing, 664-1 
      Akebono-cho, Kitami 090-0011, Japan.
FAU - Nakayama, Shoji F
AU  - Nakayama SF
AD  - Japan Environment and Children's Study Programme Office, National Institute for 
      Environmental Studies, 16-2 Onogawa, Tsukuba 305-8506, Japan.
FAU - Kamijima, Michihiro
AU  - Kamijima M
AD  - Department of Occupational and Environmental Health, Nagoya City University 
      Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, 
      Aichi 467-8601, Japan.
FAU - Kishi, Reiko
AU  - Kishi R
AD  - Center for Environmental and Health Sciences, Hokkaido University, North-12, 
      West-7, Kita-ku, Sapporo 060-0812, Japan. Electronic address: 
      rkishi@med.hokudai.ac.jp.
CN  - Japan Environment, Children's Study JECS Group
LA  - eng
PT  - Journal Article
DEP - 20231111
PL  - Netherlands
TA  - Environ Int
JT  - Environment international
JID - 7807270
RN  - 0 (Alkanesulfonic Acids)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Fluorocarbons)
RN  - 0 (Vitamins)
SB  - IM
MH  - Female
MH  - Humans
MH  - Infant
MH  - Pregnancy
MH  - *Alkanesulfonic Acids
MH  - Bayes Theorem
MH  - Birth Cohort
MH  - *Environmental Pollutants
MH  - *Fluorocarbons/toxicity
MH  - Japan
MH  - *Mucocutaneous Lymph Node Syndrome/chemically induced
MH  - Prospective Studies
MH  - Vitamins
MH  - Infant, Newborn
MH  - Child, Preschool
OTO - NOTNLM
OT  - Japan Environment and Children's Study
OT  - Kawasaki disease
OT  - Per- and polyfluoroalkyl substances
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2023/12/08 00:42
MHDA- 2024/01/25 06:43
CRDT- 2023/12/07 18:07
PHST- 2023/07/24 00:00 [received]
PHST- 2023/11/07 00:00 [revised]
PHST- 2023/11/09 00:00 [accepted]
PHST- 2024/01/25 06:43 [medline]
PHST- 2023/12/08 00:42 [pubmed]
PHST- 2023/12/07 18:07 [entrez]
AID - S0160-4120(23)00594-9 [pii]
AID - 10.1016/j.envint.2023.108321 [doi]
PST - ppublish
SO  - Environ Int. 2024 Jan;183:108321. doi: 10.1016/j.envint.2023.108321. Epub 2023 
      Nov 11.