PMID- 38062913
OWN - NLM
STAT- MEDLINE
DCOM- 20240318
LR  - 20240318
IS  - 1753-0407 (Electronic)
IS  - 1753-0393 (Print)
IS  - 1753-0407 (Linking)
VI  - 16
IP  - 3
DP  - 2024 Mar
TI  - Association of methylation risk score with incident type 2 diabetes mellitus: A 
      nested case-control study.
PG  - e13512
LID - 10.1111/1753-0407.13512 [doi]
LID - e13512
AB  - AIMS: To investigate the association of methylation risk score (MRS) and its 
      interactions with environmental factors with type 2 diabetes mellitus (T2DM) 
      risk. METHODS: We conducted a nested case-control study with 241 onset cases and 
      241 matched controls. Conditional logistic regression models were employed to 
      identify risk CpG sites. Simple and weighted MRSs were constructed based on the 
      methylation levels of ATP-binding cassette G1 gene, fat mass and obesity 
      associated gene, potassium voltage-gated channel member 1 gene, and 
      thioredoxin-interacting protein gene previously associated with T2DM to estimate 
      the association of MRS with T2DM risk. Stratified analyses were used to 
      investigate interactions between MRS and environmental factors. RESULTS: A total 
      of 10 CpG loci were identified from the aforementioned genes to calculate MRS. 
      After controlling for potential confounding factors, taking tertile 1 as 
      reference, the odds ratios (ORs) and 95% confidence intervals (CIs) for T2DM of 
      tertile 3 was 2.39 (1.36-4.20) for simple MRS and 2.59 (1.45-4.63) for weighted 
      MRS. With per SD score increment in MRS, the OR (95% CI) was 1.66 (1.29-2.14) and 
      1.60 (1.24-2.08) for simple and weighted MRSs, respectively. J-curved 
      associations were observed between both simple and weighted MRSs and T2DM risks. 
      Additionally, multiplication interactions for smoking and hypertension with 
      simple MRS on the risk of T2DM were found, similarly for smoking and obesity with 
      weighted MRS on the risk of T2DM (all P(interaction)  < .05). CONCLUSION: 
      Elevated simple and weighted MRSs were associated with increased risk of T2DM. 
      Environmental risk factors may influence the association between MRS and T2DM.
CI  - (c) 2023 The Authors. Journal of Diabetes published by Ruijin Hospital, Shanghai 
      Jiaotong University School of Medicine and John Wiley & Sons Australia, Ltd.
FAU - Huo, Weifeng
AU  - Huo W
AD  - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou 
      University, Zhengzhou, China.
FAU - Hu, Huifang
AU  - Hu H
AD  - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou 
      University, Zhengzhou, China.
FAU - Li, Tianze
AU  - Li T
AD  - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou 
      University, Zhengzhou, China.
FAU - Yuan, Lijun
AU  - Yuan L
AD  - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou 
      University, Zhengzhou, China.
FAU - Zhang, Jinli
AU  - Zhang J
AD  - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou 
      University, Zhengzhou, China.
FAU - Feng, Yifei
AU  - Feng Y
AD  - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou 
      University, Zhengzhou, China.
FAU - Wu, Yuying
AU  - Wu Y
AD  - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou 
      University, Zhengzhou, China.
FAU - Fu, Xueru
AU  - Fu X
AD  - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou 
      University, Zhengzhou, China.
FAU - Ke, Yamin
AU  - Ke Y
AD  - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou 
      University, Zhengzhou, China.
FAU - Wang, Mengmeng
AU  - Wang M
AD  - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou 
      University, Zhengzhou, China.
FAU - Zhang, Wenkai
AU  - Zhang W
AD  - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou 
      University, Zhengzhou, China.
FAU - Wang, Longkang
AU  - Wang L
AD  - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou 
      University, Zhengzhou, China.
FAU - Chen, Yaobing
AU  - Chen Y
AD  - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou 
      University, Zhengzhou, China.
FAU - Gao, Yajuan
AU  - Gao Y
AD  - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou 
      University, Zhengzhou, China.
FAU - Li, Xi
AU  - Li X
AD  - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou 
      University, Zhengzhou, China.
FAU - Liu, Jiong
AU  - Liu J
AD  - Department of Preventive Medicine, School of Public Health, Shenzhen University 
      Medical School, Shenzhen, China.
FAU - Huang, Zelin
AU  - Huang Z
AD  - Department of Preventive Medicine, School of Public Health, Shenzhen University 
      Medical School, Shenzhen, China.
FAU - Hu, Fulan
AU  - Hu F
AUID- ORCID: 0000-0002-2386-1503
AD  - Department of Biostatistics and Epidemiology, School of Public Health, Shenzhen 
      University Medical School, Shenzhen, China.
FAU - Zhang, Ming
AU  - Zhang M
AUID- ORCID: 0000-0002-2923-5335
AD  - Department of Biostatistics and Epidemiology, School of Public Health, Shenzhen 
      University Medical School, Shenzhen, China.
FAU - Sun, Liang
AU  - Sun L
AD  - Department of Social Medicine and Health Service Management, College of Public 
      Health, Zhengzhou University, Zhengzhou, China.
FAU - Hu, Dongsheng
AU  - Hu D
AUID- ORCID: 0000-0002-9998-8041
AD  - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou 
      University, Zhengzhou, China.
FAU - Zhao, Yang
AU  - Zhao Y
AD  - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou 
      University, Zhengzhou, China.
LA  - eng
GR  - 2021A1515012503/Guangdong Basic and Applied Basic Research Foundation/
GR  - 2022A1515010503/Guangdong Basic and Applied Basic Research Foundation/
GR  - 232102311017/Key R & D and promotion projects in Henan Province/
GR  - NS2022009/Nanshan District Science and Technology Program Key Project of 
      Shenzhen/
GR  - 81973152/National Natural Science Foundation of China/
GR  - 82073646/National Natural Science Foundation of China/
GR  - 82103940/National Natural Science Foundation of China/
GR  - 82273707/National Natural Science Foundation of China/
GR  - 82304228/National Natural Science Foundation of China/
GR  - 2021M692903/Postdoctoral Research Foundation of China/
GR  - JCYJ20210324093612032/Shenzhen Science and Technology Program/
GR  - JCYJ20220818095818040/Shenzhen Science and Technology Program/
PT  - Journal Article
DEP - 20231207
PL  - Australia
TA  - J Diabetes
JT  - Journal of diabetes
JID - 101504326
SB  - IM
MH  - Humans
MH  - *Diabetes Mellitus, Type 2/epidemiology/genetics
MH  - Case-Control Studies
MH  - Risk Factors
MH  - Obesity/complications/epidemiology/genetics
MH  - Methylation
PMC - PMC10940902
OTO - NOTNLM
OT  - DNA methylation
OT  - interaction analysis
OT  - methylation risk score
OT  - nested case-control study
OT  - type 2 diabetes mellitus
EDAT- 2023/12/08 06:42
MHDA- 2024/03/18 06:44
PMCR- 2023/12/07
CRDT- 2023/12/08 03:47
PHST- 2023/11/13 00:00 [revised]
PHST- 2023/09/11 00:00 [received]
PHST- 2023/11/14 00:00 [accepted]
PHST- 2024/03/18 06:44 [medline]
PHST- 2023/12/08 06:42 [pubmed]
PHST- 2023/12/08 03:47 [entrez]
PHST- 2023/12/07 00:00 [pmc-release]
AID - JDB13512 [pii]
AID - 10.1111/1753-0407.13512 [doi]
PST - ppublish
SO  - J Diabetes. 2024 Mar;16(3):e13512. doi: 10.1111/1753-0407.13512. Epub 2023 Dec 7.