PMID- 38063106
OWN - NLM
STAT- MEDLINE
DCOM- 20240105
LR  - 20240105
IS  - 1165-158X (Electronic)
IS  - 0145-5680 (Linking)
VI  - 69
IP  - 12
DP  - 2023 Nov 30
TI  - Vitamin D receptor gene polymorphism and serum vitamin D level as risk factors 
      for acquiring Type II diabetes mellitus.
PG  - 131-138
LID - 10.14715/cmb/2023.69.12.21 [doi]
AB  - The studies on the relationship between type 2 diabetes mellitus (T2DM) risk and 
      vitamin D receptor (VDR) gene polymorphisms are still inconclusive. Therefore, 
      the objective of the study was to assess possible risks of acquiring T2DM due to 
      polymorphisms in the VDR gene or abnormal serum levels of VD. 362 participants 
      (181 T2DM patients and 181 healthy controls) from the Diabetic Center, 
      Sulaimaniyah/Iraq, from December 2020 to May 2021 were volumtarily enrolled in 
      the study. For each participant, HbA1c, fasting blood sugar (FBS), serum 
      cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), 
      triglyceride (TG), markers of calcium homeostasis, alkaline phosphatase (ALP), 
      phosphorus, VD and insulin were measured. In addition, FokI, TaqI, ApaI, and BsmI 
      genotypes were also performed using Polymerase Chain Reaction (PCR). The results 
      showed that VD level was significantly lower in T2DM compared to the control 
      group. While, HbA1c was significantly higher in T2DM than in the control group. 
      In contrast to  AA (P=0.034) and CC (P=0.011) genotype of ApaI (rs7975232) gene 
      polymorphism, which were dominant among the control group, AC-genotype was 
      significantly (P=0.0001) dominat among T2DM group. Meanwhile, TT-genotype of TaqI 
      (rs731236) was  significantly (P=0.05) dominant among control group. While there 
      were not any significant differences between other genotypes among T2DM and 
      control groups. In conclusion, low VD-level is a possible risk factor for 
      developing T2DM, and an association was found, especially between ApaI genotypes 
      and T2DM.
FAU - Mohammed, Maryam Salih
AU  - Mohammed MS
AD  - Department of Biochemistry, College of Medicine, University of Sulaimani, 
      Sulaimaniyah, Iraq. maryam.mohammed@univsul.edu.iq.
FAU - Ahmed Jaff, Basima Sadiq
AU  - Ahmed Jaff BS
AD  - Department of Chemistry and Clinical Biochemistry, College of Pharmacy, 
      University of Sulaimani, Sulaimaniyah, Iraq. basima.ahmed@univsul.edu.iq.
FAU - Aziz, Sadat Abdulla
AU  - Aziz SA
AD  - Department of Anesthesia, College of Health Sciences, Cihan University 
      Sulaimaniya, Sulaymaniyah 46001, Kurdistan Region, Iraq. 
      sadat.aziz@univsul.edu.iq.
LA  - eng
PT  - Journal Article
DEP - 20231130
PL  - France
TA  - Cell Mol Biol (Noisy-le-grand)
JT  - Cellular and molecular biology (Noisy-le-Grand, France)
JID - 9216789
RN  - 0 (Glycated Hemoglobin)
RN  - 73710-32-4 (methyl 4-azidophenylacetimidate)
RN  - 0 (Receptors, Calcitriol)
RN  - 1406-16-2 (Vitamin D)
SB  - IM
MH  - Humans
MH  - Case-Control Studies
MH  - *Diabetes Mellitus, Type 2/genetics/metabolism
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Glycated Hemoglobin
MH  - Polymorphism, Genetic
MH  - Polymorphism, Single Nucleotide/genetics
MH  - *Receptors, Calcitriol/genetics
MH  - Risk Factors
MH  - *Vitamin D/blood/chemistry
EDAT- 2023/12/08 06:41
MHDA- 2023/12/17 13:19
CRDT- 2023/12/08 05:36
PHST- 2023/07/25 00:00 [received]
PHST- 2023/12/17 13:19 [medline]
PHST- 2023/12/08 06:41 [pubmed]
PHST- 2023/12/08 05:36 [entrez]
AID - 10.14715/cmb/2023.69.12.21 [doi]
PST - epublish
SO  - Cell Mol Biol (Noisy-le-grand). 2023 Nov 30;69(12):131-138. doi: 
      10.14715/cmb/2023.69.12.21.