PMID- 38064687
OWN - NLM
STAT- MEDLINE
DCOM- 20231225
LR  - 20240103
IS  - 2379-3694 (Electronic)
IS  - 2379-3694 (Linking)
VI  - 8
IP  - 12
DP  - 2023 Dec 22
TI  - R3-Noria-methanesulfonate: A Molecular Cage with Superior Hyperpolarized 
      Xenon-129 MRI Contrast.
PG  - 4707-4715
LID - 10.1021/acssensors.3c01791 [doi]
AB  - Hyperpolarized (HP) xenon-129 ((129)Xe) magnetic resonance imaging (MRI) has the 
      potential to be used as a molecular imaging modality. For this purpose, numerous 
      supramolecular cages have been developed and evaluated in the past. Herein, we 
      report a novel and unique macrocycle that can be successfully utilized for xenon 
      MRI, the resorcinarene trimer methanesulfonate (R3-Noria-MeSO(3)H). This molecule 
      is capable of two different contrast mechanisms for xenon-MRI, resulting from an 
      increase in the effective spin-spin relaxation and hyperpolarized chemical 
      exchange saturation transfer (HyperCEST). We have demonstrated a superior 
      negative contrast caused by R3-Noria-MeSO(3)H on HP (129)Xe MRI at 3.0 T as well 
      as HyperCEST imaging of the studied macrocycle. Additionally, we have found that 
      the complex aggregation behaviors of R3-Noria-methanesulfonate and its impact on 
      xenon-129 relaxivity are an area for future study.
FAU - Shepelytskyi, Yurii
AU  - Shepelytskyi Y
AUID- ORCID: 0000-0001-5526-7958
AD  - Chemistry Department, Lakehead University, 955 Oliver Road, Thunder Bay, Ontario 
      P7B 5E1, Canada.
AD  - Thunder Bay Regional Health Research Institute, 980 Oliver Road, Thunder Bay, 
      Ontario P7B 6V4, Canada.
FAU - Grynko, Vira
AU  - Grynko V
AD  - Thunder Bay Regional Health Research Institute, 980 Oliver Road, Thunder Bay, 
      Ontario P7B 6V4, Canada.
AD  - Chemistry and Materials Science Program, Lakehead University, 955 Oliver Road, 
      Thunder Bay, Ontario P7B 5E1, Canada.
FAU - Batarchuk, Viktoriia
AU  - Batarchuk V
AD  - Chemistry Department, Lakehead University, 955 Oliver Road, Thunder Bay, Ontario 
      P7B 5E1, Canada.
AD  - Thunder Bay Regional Health Research Institute, 980 Oliver Road, Thunder Bay, 
      Ontario P7B 6V4, Canada.
FAU - Hasselbrink, Carson L
AU  - Hasselbrink CL
AD  - Department of Chemistry, University of Rhode Island, Kingston, Rhode Island 
      02881, United States.
FAU - Kovacs, Antal H
AU  - Kovacs AH
AD  - Applied Life Science Program, Lakehead University, 955 Oliver Road, Thunder Bay, 
      Ontario P7B 5E1, Canada.
FAU - Ruset, Iulian C
AU  - Ruset IC
AD  - Xemed LCC, 16 Strafford Avenue, Durham, New Hampshire 03824, United States.
FAU - Rodriguez, Karla
AU  - Rodriguez K
AD  - Chemistry Department, Lakehead University, 955 Oliver Road, Thunder Bay, Ontario 
      P7B 5E1, Canada.
FAU - Al Taradeh, Nedal
AU  - Al Taradeh N
AD  - Chemistry Department, Lakehead University, 955 Oliver Road, Thunder Bay, Ontario 
      P7B 5E1, Canada.
FAU - Talwar, Tanu
AU  - Talwar T
AD  - Chemistry Department, Lakehead University, 955 Oliver Road, Thunder Bay, Ontario 
      P7B 5E1, Canada.
FAU - DeBoef, Brenton
AU  - DeBoef B
AUID- ORCID: 0000-0002-9270-2557
AD  - Department of Chemistry, University of Rhode Island, Kingston, Rhode Island 
      02881, United States.
FAU - Albert, Mitchell S
AU  - Albert MS
AD  - Chemistry Department, Lakehead University, 955 Oliver Road, Thunder Bay, Ontario 
      P7B 5E1, Canada.
AD  - Thunder Bay Regional Health Research Institute, 980 Oliver Road, Thunder Bay, 
      Ontario P7B 6V4, Canada.
AD  - Northern Ontario School of Medicine, 955 Oliver Road, Thunder Bay, Ontario P7B 
      5E1, Canada.
LA  - eng
PT  - Journal Article
DEP - 20231208
PL  - United States
TA  - ACS Sens
JT  - ACS sensors
JID - 101669031
RN  - 0 (Xenon-129)
RN  - 0 (Xenon Isotopes)
RN  - 3H3U766W84 (Xenon)
RN  - 0 (Contrast Media)
RN  - 0 (Mesylates)
SB  - IM
MH  - *Magnetic Resonance Imaging/methods
MH  - *Xenon Isotopes/chemistry
MH  - Xenon/chemistry
MH  - Contrast Media/chemistry
MH  - Mesylates
OTO - NOTNLM
OT  - HyperCEST
OT  - Noria
OT  - R3-Noria-methanesulfonate
OT  - chemical exchange
OT  - magnetic resonance imaging
OT  - magnetic resonance spectroscopy
OT  - xenon-129
EDAT- 2023/12/08 18:42
MHDA- 2023/12/25 06:42
CRDT- 2023/12/08 16:43
PHST- 2023/12/25 06:42 [medline]
PHST- 2023/12/08 18:42 [pubmed]
PHST- 2023/12/08 16:43 [entrez]
AID - 10.1021/acssensors.3c01791 [doi]
PST - ppublish
SO  - ACS Sens. 2023 Dec 22;8(12):4707-4715. doi: 10.1021/acssensors.3c01791. Epub 2023 
      Dec 8.