PMID- 38065591
OWN - NLM
STAT- MEDLINE
DCOM- 20231216
LR  - 20240515
IS  - 1473-4893 (Electronic)
IS  - 1470-2118 (Print)
IS  - 1470-2118 (Linking)
VI  - 23
IP  - 6
DP  - 2023 Nov
TI  - Health-related quality of life following TAVI or cardiac surgery in patients at 
      intermediate and low risk: a systematic review and meta-analysis.
PG  - 594-605
LID - S1470-2118(24)00032-0 [pii]
LID - 10.7861/clinmed.2023-0258 [doi]
AB  - Recent randomised trials have shown that clinical outcomes with transcatheter 
      aortic valve implantation (TAVI) are non-inferior to surgical aortic valve 
      replacement (SAVR) in patients with symptomatic aortic stenosis at intermediate 
      to low risk. Health-related quality of life (HrQoL) outcomes in these patient 
      groups remain uncertain. A systematic search of the literature was conducted that 
      included nine trials and 11,295 patients. Kansas City Cardiomyopathy 
      Questionnaire (KCCQ), a heart-failure-specific measure and EuroQol-5D (EQ-5D) (a 
      generic health status tool) changes were the primary outcomes. New York Heart 
      Association (NYHA) classification was the secondary outcome. Improvement in KCCQ 
      scores was greater with TAVI (mean difference (MD)=13.56, 95% confidence interval 
      (CI) 11.67-15.46, p<0.001) at 1 month, as was the improvement in EQ-5D (MD=0.07, 
      95% CI 0.05-0.08, p<0.001). There was no difference in KCCQ (MD=1.05, 95% CI 
      -0.11 to 2.21, p=0.08) or EQ-5D (MD=-0.01, 95% CI -0.03 to 0.01), p=0.37) at 12 
      months. NYHA functional class 3/4 was lower in patients undergoing TAVI at 1 
      month (MD=0.51, 95% CI 0.34-0.78, p=0.002), but there was no difference at 12 
      months (MD=1.10; 95% CI 0.87-1.38, p=0.43). Overall, TAVI offers early benefit in 
      HRQoL outcomes compared with SAVR, but they are equivalent at 12 months.
CI  - (c) Royal College of Physicians 2023. All rights reserved.
FAU - Gonnah, Ahmed R
AU  - Gonnah AR
AD  - Imperial College Healthcare NHS Trust, London, UK ahmedgonnah18@outlook.com.
FAU - Abdelwahab, Mohamed
AU  - Abdelwahab M
AD  - Boston University, Boston, MA, USA.
FAU - Taylor, Rebecca
AU  - Taylor R
AD  - Blackpool Teaching Hospitals NHS Foundation Trust, Blackpool, UK.
FAU - Labib, Aser
AU  - Labib A
AD  - Southport and Ormskirk NHS Foundation Trust, Southport, UK.
FAU - Masoud, Omar
AU  - Masoud O
AD  - University College London Hospitals NHS Foundation Trust, London, UK.
FAU - Debski, Maciej
AU  - Debski M
AD  - University of East Anglia, Norwich, UK and research fellow, Norfolk and Norwich 
      University Hospital, Norwich, UK.
FAU - Abdelaziz, Hesham Kamal
AU  - Abdelaziz HK
AD  - Lancashire Cardiac Centre, Blackpool, UK.
FAU - Roberts, David Hesketh
AU  - Roberts DH
AD  - Lancashire Cardiac Centre, Blackpool, UK, and honorary senior lecturer, 
      University of Liverpool, Merseyside Liverpool.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PT  - Systematic Review
PL  - England
TA  - Clin Med (Lond)
JT  - Clinical medicine (London, England)
JID - 101092853
SB  - IM
MH  - Humans
MH  - *Transcatheter Aortic Valve Replacement
MH  - Quality of Life
MH  - *Aortic Valve Stenosis/surgery
MH  - Aortic Valve
MH  - Risk
MH  - Treatment Outcome
MH  - Risk Factors
PMC - PMC11046617
OTO - NOTNLM
OT  - EQ-5D
OT  - KCCQ
OT  - NYHA
OT  - SAVR
OT  - TAVI
OT  - aortic stenosis
EDAT- 2023/12/09 05:43
MHDA- 2023/12/17 09:45
PMCR- 2024/03/15
CRDT- 2023/12/08 20:43
PHST- 2023/12/17 09:45 [medline]
PHST- 2023/12/09 05:43 [pubmed]
PHST- 2023/12/08 20:43 [entrez]
PHST- 2024/03/15 00:00 [pmc-release]
AID - S1470-2118(24)00032-0 [pii]
AID - 10.7861/clinmed.2023-0258 [doi]
PST - ppublish
SO  - Clin Med (Lond). 2023 Nov;23(6):594-605. doi: 10.7861/clinmed.2023-0258.