PMID- 38068375 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20231209 IS - 2077-0383 (Print) IS - 2077-0383 (Electronic) IS - 2077-0383 (Linking) VI - 12 IP - 23 DP - 2023 Nov 26 TI - Percutaneous Deep Venous Arterialization for Limb Salvage in No Option Patients with Chronic Limb-Threatening Ischemia. LID - 10.3390/jcm12237324 [doi] LID - 7324 AB - An endovascular approach is often considered the first line treatment option for lower limb chronic limb-threatening ischemia (CLTI), which is defined by the presence of ischemic rest pain and severe tissue loss, such as ulcers or gangrene. Although the technical success rate of endovascular revascularization is high, in specific patients with advanced infrapopliteal disease and the absence of run-off tibial vessels, the so-called 'desert foot', the chance of successful endovascular revascularization is minimal. In order to avoid primary amputation, several treatment options are currently being investigated, including gene therapy and deep venous arterialization. This review focuses on the percutaneous deep venous arterialization technique as a promising, minimally invasive treatment option for limb salvage in CLTI patients presenting with a 'desert foot'. FAU - Spiliopoulos, Stavros AU - Spiliopoulos S AUID- ORCID: 0000-0003-1860-0568 AD - 2nd Department of Radiology, Interventional Radiology Unit, Medical School, National and Kapodistrian University of Athens, "Attikon" University General Hospital, 15784 Athens, Greece. FAU - Davoutis, Efstathia AU - Davoutis E AD - 2nd Department of Radiology, Interventional Radiology Unit, Medical School, National and Kapodistrian University of Athens, "Attikon" University General Hospital, 15784 Athens, Greece. FAU - Arkoudis, Nikolaos-Achilleas AU - Arkoudis NA AUID- ORCID: 0000-0002-0783-5700 AD - 2nd Department of Radiology, Interventional Radiology Unit, Medical School, National and Kapodistrian University of Athens, "Attikon" University General Hospital, 15784 Athens, Greece. FAU - Sritharan, Kaji AU - Sritharan K AD - Department of Vascular Surgery, Liverpool University NHS Foundation Trust, Liverpool L69 3BX, UK. FAU - Lechareas, Symeon AU - Lechareas S AD - Department of Interventional Radiology, Liverpool University NHS Foundation Trust, Liverpool L69 3BX, UK. LA - eng PT - Journal Article PT - Review DEP - 20231126 PL - Switzerland TA - J Clin Med JT - Journal of clinical medicine JID - 101606588 PMC - PMC10707469 OTO - NOTNLM OT - chronic limb-threatening ischemia OT - desert foot OT - endovascular treatment OT - percutaneous deep venous arterialization COIS- The authors declare no conflict of interest. EDAT- 2023/12/09 10:44 MHDA- 2023/12/09 10:45 PMCR- 2023/11/26 CRDT- 2023/12/09 01:10 PHST- 2023/09/23 00:00 [received] PHST- 2023/11/23 00:00 [revised] PHST- 2023/11/24 00:00 [accepted] PHST- 2023/12/09 10:45 [medline] PHST- 2023/12/09 10:44 [pubmed] PHST- 2023/12/09 01:10 [entrez] PHST- 2023/11/26 00:00 [pmc-release] AID - jcm12237324 [pii] AID - jcm-12-07324 [pii] AID - 10.3390/jcm12237324 [doi] PST - epublish SO - J Clin Med. 2023 Nov 26;12(23):7324. doi: 10.3390/jcm12237324.