PMID- 38069179
OWN - NLM
STAT- MEDLINE
DCOM- 20231216
LR  - 20231216
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 24
IP  - 23
DP  - 2023 Nov 28
TI  - Endogenous Extracellular Vesicles Participate in Brain Remodeling after Ischemic 
      Stroke.
LID - 10.3390/ijms242316857 [doi]
LID - 16857
AB  - Brain remodeling after an ischemic stroke represents a promising avenue for 
      exploring the cellular mechanisms of endogenous brain repair. A deeper 
      understanding of these mechanisms is crucial for optimizing the safety and 
      efficacy of neuroprotective treatments for stroke patients. Here, we interrogated 
      the role of extracellular vesicles, particularly exosomes, as potential mediators 
      of endogenous repair within the neurovascular unit (NVU). We hypothesized that 
      these extracellular vesicles may play a role in achieving transient stroke 
      neuroprotection. Using the established ischemic stroke model of middle cerebral 
      artery occlusion in adult rats, we detected a surged in the extracellular vesicle 
      marker CD63 in the peri-infarct area that either juxtaposed or co-localized with 
      GFAP-positive glial cells, MAP2-labeled young neurons, and VEGF-marked angiogenic 
      cells. This novel observation that CD63 exosomes spatially and temporally 
      approximated glial activation, neurogenesis, and angiogenesis suggests that 
      extracellular vesicles, especially exosomes, contribute to the endogenous repair 
      of the NVU, warranting exploration of extracellular vesicle-based stroke 
      therapeutics.
FAU - Alvarez, Mauricio Muleiro
AU  - Alvarez MM
AUID- ORCID: 0009-0007-6628-4973
AD  - Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and 
      Brain Repair, Morsani College of Medicine, University of South Florida, 12901 
      Bruce B. Downs Blvd., Tampa, FL 33612, USA.
FAU - Salazar, Felipe Esparza
AU  - Salazar FE
AUID- ORCID: 0000-0003-1884-5389
AD  - Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and 
      Brain Repair, Morsani College of Medicine, University of South Florida, 12901 
      Bruce B. Downs Blvd., Tampa, FL 33612, USA.
FAU - Rodriguez, Thomas
AU  - Rodriguez T
AD  - Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and 
      Brain Repair, Morsani College of Medicine, University of South Florida, 12901 
      Bruce B. Downs Blvd., Tampa, FL 33612, USA.
FAU - D'Egidio, Francesco
AU  - D'Egidio F
AUID- ORCID: 0000-0001-9695-6274
AD  - Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and 
      Brain Repair, Morsani College of Medicine, University of South Florida, 12901 
      Bruce B. Downs Blvd., Tampa, FL 33612, USA.
FAU - Borlongan, Cesar V
AU  - Borlongan CV
AUID- ORCID: 0000-0002-2966-9782
AD  - Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and 
      Brain Repair, Morsani College of Medicine, University of South Florida, 12901 
      Bruce B. Downs Blvd., Tampa, FL 33612, USA.
FAU - Lee, Jea-Young
AU  - Lee JY
AUID- ORCID: 0000-0001-5270-3224
AD  - Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and 
      Brain Repair, Morsani College of Medicine, University of South Florida, 12901 
      Bruce B. Downs Blvd., Tampa, FL 33612, USA.
LA  - eng
PT  - Journal Article
DEP - 20231128
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
SB  - IM
MH  - Humans
MH  - Rats
MH  - Animals
MH  - *Ischemic Stroke
MH  - Brain
MH  - *Stroke
MH  - Infarction, Middle Cerebral Artery
MH  - *Extracellular Vesicles
MH  - *Brain Ischemia
PMC - PMC10706116
OTO - NOTNLM
OT  - angiogenesis
OT  - cerebral ischemia
OT  - exosomes
OT  - glial activation
OT  - neurogenesis
OT  - neuroprotection
COIS- The authors declare no conflict of interest.
EDAT- 2023/12/09 10:45
MHDA- 2023/12/17 09:42
PMCR- 2023/11/28
CRDT- 2023/12/09 01:15
PHST- 2023/10/27 00:00 [received]
PHST- 2023/11/21 00:00 [revised]
PHST- 2023/11/26 00:00 [accepted]
PHST- 2023/12/17 09:42 [medline]
PHST- 2023/12/09 10:45 [pubmed]
PHST- 2023/12/09 01:15 [entrez]
PHST- 2023/11/28 00:00 [pmc-release]
AID - ijms242316857 [pii]
AID - ijms-24-16857 [pii]
AID - 10.3390/ijms242316857 [doi]
PST - epublish
SO  - Int J Mol Sci. 2023 Nov 28;24(23):16857. doi: 10.3390/ijms242316857.