PMID- 38071260 OWN - NLM STAT- MEDLINE DCOM- 20231216 LR - 20240314 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 13 IP - 1 DP - 2023 Dec 9 TI - General Movements trajectories and outcome at 12 months in very preterm infants: An analysis of tendencies and pathological persistence. PG - 21825 LID - 10.1038/s41598-023-49037-w [doi] LID - 21825 AB - Very preterm infants (VPI) < 32 weeks are at increased risk of developmental disorders detectable using the Prechtl General Movements Assessment (GMA) and the Bayley Scales of Infant and Toddler Development-Third Edition (BSID-III). The aim of this study was to investigate General Movements (GMs) trajectories from preterm to fidgety age including GMs tendencies and their association with cognitive and motor outcome. Retrospective analysis of VPI with GMA at preterm (35 +/- 2 weeks postmenstrual age (PMA), T1) and fidgety age (12 +/- 3 weeks corrected age CA), T2), and BSID-III (12 +/- 3 months CA, T3) is performed. Data are analysed using Pearson chi(2)-test, Fisher-Freeman-Halton Exact test, and residual analyses. This study found significant associations between (a) GMs (T1) and (b) persistent pathological GMs (T1 + T2) with cognitive outcomes at 12 months (T3) considering the tendencies of GMs in addition to the global character (p = 0.007, p = 0.022, respectively), representing medium-sized effects. There were no significant associations between GMs or persistence of pathological GMs and gross and fine motor outcomes, regardless of GMs tendencies. Findings indicate that considering tendencies of GMs and the persistence of pathological GMs may be important in identifying children at risk of cognitive impairments early. This additional assessment parameter may have the potential for early identification of infants with milder motor and/or cognitive impairments. However, more research is needed using larger sample cohorts to generalise the results and to be able to recommend sequential GMA for clinical routine. CI - (c) 2023. The Author(s). FAU - Teschler, Uta AU - Teschler U AD - Department of Paediatrics I, Neonatology, Paediatric Intensive Care and Paediatric Neurology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany. uta.teschler@uk-essen.de. AD - Center for Translational Neuro- and Behavioral Sciences, University Hospital Essen, University of Duisburg-Essen, Essen, Germany. uta.teschler@uk-essen.de. FAU - Dathe, Anne-Kathrin AU - Dathe AK AD - Department of Paediatrics I, Neonatology, Paediatric Intensive Care and Paediatric Neurology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany. AD - Center for Translational Neuro- and Behavioral Sciences, University Hospital Essen, University of Duisburg-Essen, Essen, Germany. AD - Department of Health and Nursing, Occupational Therapy, Ernst-Abbe-University of Applied Sciences, Jena, Germany. FAU - Heuser-Spura, Katharina Maria AU - Heuser-Spura KM AD - Department of Paediatrics I, Neonatology, Paediatric Intensive Care and Paediatric Neurology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany. AD - Center for Translational Neuro- and Behavioral Sciences, University Hospital Essen, University of Duisburg-Essen, Essen, Germany. FAU - Bialas, Johanna AU - Bialas J AD - Department of Paediatrics I, Neonatology, Paediatric Intensive Care and Paediatric Neurology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany. AD - Center for Translational Neuro- and Behavioral Sciences, University Hospital Essen, University of Duisburg-Essen, Essen, Germany. FAU - Cordier, Larissa Jane AU - Cordier LJ AD - Department of Paediatrics I, Neonatology, Paediatric Intensive Care and Paediatric Neurology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany. AD - Center for Translational Neuro- and Behavioral Sciences, University Hospital Essen, University of Duisburg-Essen, Essen, Germany. FAU - Albayrak, Bilge AU - Albayrak B AD - Department of Paediatrics I, Neonatology, Paediatric Intensive Care and Paediatric Neurology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany. AD - Center for Translational Neuro- and Behavioral Sciences, University Hospital Essen, University of Duisburg-Essen, Essen, Germany. FAU - Felderhoff-Mueser, Ursula AU - Felderhoff-Mueser U AD - Department of Paediatrics I, Neonatology, Paediatric Intensive Care and Paediatric Neurology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany. AD - Center for Translational Neuro- and Behavioral Sciences, University Hospital Essen, University of Duisburg-Essen, Essen, Germany. FAU - Huening, Britta Maria AU - Huening BM AD - Department of Paediatrics I, Neonatology, Paediatric Intensive Care and Paediatric Neurology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany. AD - Center for Translational Neuro- and Behavioral Sciences, University Hospital Essen, University of Duisburg-Essen, Essen, Germany. LA - eng PT - Journal Article DEP - 20231209 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Infant MH - Female MH - Humans MH - Infant, Newborn MH - *Infant, Premature MH - Retrospective Studies MH - Movement MH - Infant, Very Low Birth Weight MH - Fetal Growth Retardation MH - *Infant, Premature, Diseases PMC - PMC10710415 COIS- The authors declare no competing interests. EDAT- 2023/12/10 06:43 MHDA- 2023/12/17 09:41 PMCR- 2023/12/09 CRDT- 2023/12/09 23:12 PHST- 2023/07/07 00:00 [received] PHST- 2023/12/03 00:00 [accepted] PHST- 2023/12/17 09:41 [medline] PHST- 2023/12/10 06:43 [pubmed] PHST- 2023/12/09 23:12 [entrez] PHST- 2023/12/09 00:00 [pmc-release] AID - 10.1038/s41598-023-49037-w [pii] AID - 49037 [pii] AID - 10.1038/s41598-023-49037-w [doi] PST - epublish SO - Sci Rep. 2023 Dec 9;13(1):21825. doi: 10.1038/s41598-023-49037-w.