PMID- 38071452
OWN - NLM
STAT- MEDLINE
DCOM- 20240111
LR  - 20240319
IS  - 1540-8159 (Electronic)
IS  - 0147-8389 (Linking)
VI  - 47
IP  - 1
DP  - 2024 Jan
TI  - Beyond biventricular pacing: Exploring the advantages of his-bundle pacing and 
      left bundle branch pacing in heart failure-A systematic review and meta-analysis.
PG  - 156-166
LID - 10.1111/pace.14892 [doi]
AB  - BACKGROUND: This meta-analysis compares His-Purkinje system pacing (HPSP), a 
      novel cardiac resynchronization therapy (CRT) technique that targets the 
      intrinsic conduction system of the heart, with conventional biventricular pacing 
      (BiVP) in heart failure (HF) patients with left ventricular (LV) dysfunction and 
      dyssynchrony. METHODS: We searched multiple databases up to May 2023 and 
      identified 18 studies (five randomized controlled trials and 13 observational 
      studies) involving 1291 patients. The outcome measures were QRS duration, left 
      ventricular ejection fraction (LVEF) improvement, left ventricular end-diastolic 
      diameter (LVEDD) change, HF hospitalization, and New York Heart Association 
      (NYHA) functional class improvement. We used a random-effects model to calculate 
      odds ratios (OR), and mean differences (MD) with 95% confidence intervals (CI). 
      We also assessed the methodological quality of the studies. RESULTS: The mean 
      LVEF was 30.7% and the mean follow-up duration was 8.1 months. Among LBBP, HBP, 
      and BiVP, HBP provided the shortest QRS duration [MD: -18.84 ms, 95% CI: -28.74 
      to -8.94; p = 0.0002], while LBBP showed the greatest improvement in LVEF [MD: 
      5.74, 95% CI: 2.74 to 7.46; p < 0.0001], LVEDD [MD: -5.55 mm, 95% CI: -7.51 to 
      -3.59; p < 0.00001], and NYHA functional class [MD: -0.58, 95% CI: -0.80 to 
      --0.35; p < 0.00001]. However, there was no significant difference in HF 
      hospitalization between HPSP and BiVP. CONCLUSION: LBBP as modality of HPSP 
      demonstrated superior outcomes in achieving electrical ventricular synchrony and 
      systolic function, as well as alleviating HF symptoms, compared to other pacing 
      techniques.
CI  - (c) 2023 Wiley Periodicals LLC.
FAU - Al Hennawi, Hussam
AU  - Al Hennawi H
AUID- ORCID: 0000-0002-1968-4962
AD  - Department of Internal Medicine, Jefferson Abington Hospital, Abington, 
      Philadelphia, USA.
FAU - Khan, Muhammad Khuzzaim
AU  - Khan MK
AUID- ORCID: 0000-0003-4586-8607
AD  - Department of Internal Medicine, Dow University of Health Sciences, Karachi, 
      Pakistan.
FAU - Khalid, Momina
AU  - Khalid M
AD  - Department of Internal Medicine, Jinnah Sindh Medical University Karachi, 
      Karachi, Pakistan.
FAU - Khalid, Hiba
AU  - Khalid H
AD  - Department of Internal Medicine, Dow University of Health Sciences, Karachi, 
      Pakistan.
FAU - Fatima, Laveeza
AU  - Fatima L
AD  - Department of Internal Medicine, Allama Iqbal Medical College, Lahore, Pakistan.
FAU - Ashraf, Muhammad Talal
AU  - Ashraf MT
AD  - Department of Internal Medicine, Dow University of Health Sciences, Karachi, 
      Pakistan.
FAU - Bhimani, Sameer
AU  - Bhimani S
AD  - Department of Internal Medicine, Jinnah Sindh Medical University Karachi, 
      Karachi, Pakistan.
FAU - Pavri, Behzad B
AU  - Pavri BB
AUID- ORCID: 0000-0003-1240-7812
AD  - Division of Cardiology, Thomas Jefferson University Hospital, Philadelphia, USA.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Systematic Review
DEP - 20231209
PL  - United States
TA  - Pacing Clin Electrophysiol
JT  - Pacing and clinical electrophysiology : PACE
JID - 7803944
SB  - IM
MH  - Humans
MH  - *Cardiac Resynchronization Therapy/methods
MH  - Stroke Volume
MH  - Ventricular Function, Left
MH  - Treatment Outcome
MH  - *Heart Failure
MH  - Bundle of His
MH  - Electrocardiography/methods
MH  - Cardiac Pacing, Artificial/methods
OTO - NOTNLM
OT  - His-Purkinje system pacing
OT  - cardiac resynchronization therapy
OT  - heart failure
OT  - pacing techniques
EDAT- 2023/12/10 08:41
MHDA- 2024/01/11 07:42
CRDT- 2023/12/10 02:41
PHST- 2023/10/23 00:00 [revised]
PHST- 2023/09/09 00:00 [received]
PHST- 2023/11/17 00:00 [accepted]
PHST- 2024/01/11 07:42 [medline]
PHST- 2023/12/10 08:41 [pubmed]
PHST- 2023/12/10 02:41 [entrez]
AID - 10.1111/pace.14892 [doi]
PST - ppublish
SO  - Pacing Clin Electrophysiol. 2024 Jan;47(1):156-166. doi: 10.1111/pace.14892. Epub 
      2023 Dec 9.