PMID- 38072753
OWN - NLM
STAT- MEDLINE
DCOM- 20240101
LR  - 20240425
IS  - 1873-2518 (Electronic)
IS  - 0264-410X (Linking)
VI  - 42
IP  - 2
DP  - 2024 Jan 12
TI  - What determines mpox vaccination uptake? Assessing the effect of 
      intent-to-vaccinate versus other determinants among men who have sex with men.
PG  - 186-193
LID - S0264-410X(23)01449-4 [pii]
LID - 10.1016/j.vaccine.2023.12.018 [doi]
AB  - BACKGROUND: In response to the mpox outbreak, vaccination was offered in the 
      Netherlands to men who have sex with men (MSM) at increased risk for mpox. 
      Successful vaccination campaigns are leveraged by high intent-to-vaccinate, yet 
      intent might not always lead to uptake. Therefore, we assessed the impact of 
      intent-to-vaccinate and other factors on vaccination uptake among participants of 
      the Amsterdam Cohort Studies (ACS). METHOD: In July 2022, prior to the mpox 
      vaccination campaign, we distributed an online survey regarding mpox 
      intent-to-vaccinate, as well as e.g. beliefs, attitude, subjective norms, and 
      perception of risk among ACS participants (all MSM). Vaccination uptake was 
      self-reported during study visits after August 2022. The association between 
      vaccination intent and uptake, and determinants of intent, was jointly assessed 
      using a structural equation model (SEM) based on components of the Theory of 
      Planned Behavior (TPB). In a second SEM, determinants of intent were allowed to 
      have a direct effect on vaccination uptake. RESULTS: 492 MSM (median 
      age = 46 years) were included in analyses. 380 (77%) had high intent-to-vaccinate 
      and 238 (48%) received at least one vaccine dose. In the first model with a 
      direct relation between intent and uptake only, TBP components predicted intent 
      as expected, and high intent-to-vaccinate was significantly associated with 
      getting vaccinated (beta = 1.1, 95%CI = 0.6-1.5). However, 175/380 (46%) 
      participants with high intent-to-vaccinate did not get vaccinated. The second 
      model had an improved model fit compared to the first model. The effect of intent 
      on uptake was non-significant, and only perceiving to be at higher risk of 
      infection significantly increased vaccination uptake later on (beta = 0.42, 
      95%CI = 0.26-0.59). Having a steady relationship decreased the probability of 
      vaccination (beta = -0.59, 95%CI = -1.0- -0.18). CONCLUSIONS: While 
      intent-to-vaccinate for mpox was high among MSM, high intent did not necessarily 
      result in vaccine uptake. Mpox risk perception might have played a more pivotal 
      role in getting vaccinated, which may be related to the evolution of vaccination 
      eligibility criteria and accessibility to the vaccine.
CI  - Copyright (c) 2023 The Author(s). Published by Elsevier Ltd.. All rights reserved.
FAU - Jongen, Vita W
AU  - Jongen VW
AD  - Department of Infectious Diseases, Public Health Service of Amsterdam (GGD 
      Amsterdam), Amsterdam, the Netherlands; Stichting hiv monitoring, Amsterdam, the 
      Netherlands. Electronic address: vjongen@ggd.amsterdam.nl.
FAU - Groot Bruinderink, Marije L
AU  - Groot Bruinderink ML
AD  - Department of Infectious Diseases, Public Health Service of Amsterdam (GGD 
      Amsterdam), Amsterdam, the Netherlands; Department of Social Psychology, 
      University of Amsterdam, Amsterdam, the Netherlands.
FAU - Boyd, Anders
AU  - Boyd A
AD  - Department of Infectious Diseases, Public Health Service of Amsterdam (GGD 
      Amsterdam), Amsterdam, the Netherlands; Stichting hiv monitoring, Amsterdam, the 
      Netherlands; Amsterdam UMC location University of Amsterdam, Department of 
      Internal Medicine, Meibergdreef 9, Amsterdam, the Netherlands; Amsterdam 
      Institute for Infection and Immunity (AII), Amsterdam, the Netherlands.
FAU - Koole, Jeffrey C D
AU  - Koole JCD
AD  - Department of Infectious Diseases, Public Health Service of Amsterdam (GGD 
      Amsterdam), Amsterdam, the Netherlands.
FAU - Teker, Buhari
AU  - Teker B
AD  - Department of Infectious Diseases, Public Health Service of Amsterdam (GGD 
      Amsterdam), Amsterdam, the Netherlands.
FAU - Dukers-Muijrers, Nicole H T M
AU  - Dukers-Muijrers NHTM
AD  - Department of Sexual Health, Infectious Diseases, and Environmental Health, 
      Heerlen, South Limburg Public Health Service, the Netherlands; Department of 
      Health Promotion, Care and Public Health Research Institute (CAPHRI), Maastricht 
      University Medical Center (MUMC+), Maastricht, the Netherlands.
FAU - Evers, Ymke J
AU  - Evers YJ
AD  - Department of Sexual Health, Infectious Diseases, and Environmental Health, 
      Heerlen, South Limburg Public Health Service, the Netherlands; Department of 
      Social Medicine, Care and Public Health Research Institute (CAPHRI), Maastricht 
      University Medical Center (MUMC+), Maastricht, the Netherlands.
FAU - Schim van der Loeff, Maarten F
AU  - Schim van der Loeff MF
AD  - Department of Infectious Diseases, Public Health Service of Amsterdam (GGD 
      Amsterdam), Amsterdam, the Netherlands; Amsterdam UMC location University of 
      Amsterdam, Department of Internal Medicine, Meibergdreef 9, Amsterdam, the 
      Netherlands; Amsterdam Institute for Infection and Immunity (AII), Amsterdam, the 
      Netherlands; Amsterdam Public Health Research Institute (APH), Amsterdam, the 
      Netherlands.
FAU - Prins, Maria
AU  - Prins M
AD  - Department of Infectious Diseases, Public Health Service of Amsterdam (GGD 
      Amsterdam), Amsterdam, the Netherlands; Amsterdam UMC location University of 
      Amsterdam, Department of Internal Medicine, Meibergdreef 9, Amsterdam, the 
      Netherlands; Amsterdam Institute for Infection and Immunity (AII), Amsterdam, the 
      Netherlands; Amsterdam Public Health Research Institute (APH), Amsterdam, the 
      Netherlands.
FAU - de Vries, Henry J C
AU  - de Vries HJC
AD  - Department of Infectious Diseases, Public Health Service of Amsterdam (GGD 
      Amsterdam), Amsterdam, the Netherlands; Amsterdam Institute for Infection and 
      Immunity (AII), Amsterdam, the Netherlands; Amsterdam Public Health Research 
      Institute (APH), Amsterdam, the Netherlands; Amsterdam UMC location University of 
      Amsterdam, Department of Dermatology, +Meibergdreef 9, Amsterdam, the 
      Netherlands.
FAU - Matser, Amy
AU  - Matser A
AD  - Department of Infectious Diseases, Public Health Service of Amsterdam (GGD 
      Amsterdam), Amsterdam, the Netherlands; Amsterdam UMC location University of 
      Amsterdam, Department of Internal Medicine, Meibergdreef 9, Amsterdam, the 
      Netherlands; Amsterdam Institute for Infection and Immunity (AII), Amsterdam, the 
      Netherlands; Amsterdam Public Health Research Institute (APH), Amsterdam, the 
      Netherlands.
FAU - Davidovich, Udi
AU  - Davidovich U
AD  - Department of Infectious Diseases, Public Health Service of Amsterdam (GGD 
      Amsterdam), Amsterdam, the Netherlands; Department of Social Psychology, 
      University of Amsterdam, Amsterdam, the Netherlands.
LA  - eng
PT  - Journal Article
DEP - 20231209
PL  - Netherlands
TA  - Vaccine
JT  - Vaccine
JID - 8406899
RN  - 0 (Smallpox Vaccine)
SB  - IM
MH  - Male
MH  - Humans
MH  - Middle Aged
MH  - Homosexuality, Male
MH  - *Smallpox Vaccine
MH  - *Mpox (monkeypox)
MH  - *Sexual and Gender Minorities
MH  - Vaccination
OTO - NOTNLM
OT  - Intention
OT  - Men who have sex with men
OT  - Monkeypox
OT  - Smallpox Vaccine
OT  - Vaccination
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2023/12/11 00:42
MHDA- 2024/01/02 11:44
CRDT- 2023/12/10 21:58
PHST- 2023/08/24 00:00 [received]
PHST- 2023/11/08 00:00 [revised]
PHST- 2023/12/03 00:00 [accepted]
PHST- 2024/01/02 11:44 [medline]
PHST- 2023/12/11 00:42 [pubmed]
PHST- 2023/12/10 21:58 [entrez]
AID - S0264-410X(23)01449-4 [pii]
AID - 10.1016/j.vaccine.2023.12.018 [doi]
PST - ppublish
SO  - Vaccine. 2024 Jan 12;42(2):186-193. doi: 10.1016/j.vaccine.2023.12.018. Epub 2023 
      Dec 9.