PMID- 38073455
OWN - NLM
STAT- MEDLINE
DCOM- 20231216
LR  - 20240108
IS  - 1307-7945 (Electronic)
IS  - 1306-696X (Print)
IS  - 1306-696X (Linking)
VI  - 29
IP  - 12
DP  - 2023 Dec
TI  - Protective effects of passiflora incarnata on ovarian ischemia/reperfusion damage 
      in rats with ovarian torsion.
PG  - 1344-1350
LID - 10.14744/tjtes.2023.52986 [doi]
AB  - BACKGROUND: This study aimed to investigate whether Passiflora Incarnata (PI) has 
      a protective effect against ischemia-reperfu-sion (IR)-induced oxidative and 
      inflammatory ovarian damage. METHODS: The effects of PI on ovarian 
      ischemia-reperfusion injury were investigated in female Wistar albino rats. The 
      animals were randomly divided into three groups: Group 1 (sham), Group 2 (IR), 
      and Group 3 (IR+PI). RESULTS: The mean levels of Malondialdehyde (MDA), 
      Myeloperoxidase (MPO), and Total Oxidant Status (TOS) were higher in the IR group 
      (p=0.025, p<0.001, and p=0.016, respectively). The Total Antioxidant Status (TAS) 
      levels were lower in the IR group (p=0.005). Immunostaining revealed significant 
      differences across the groups for Tumor necrosis factor-alpha (TNF-alpha): 13.84%, 
      49.51%, and 22.51% for Groups 1, 2, and 3, respectively (p<0.01). Bax: 10.53%, 
      46.74%, and 26.46% for Groups 1, 2, and 3, respectively (p<0.01). Annexin V: 
      12.24%, 44.86%, and 23.28% for Groups 1, 2, and 3, respectively (p<0.01). The 
      mean scores for hemorrhage, inflammation, follicular degeneration, and congestion 
      showed significant variations among the groups, all registering p<0.001. 
      CONCLUSION: Passiflora Incarnata exhibited antioxidant, anti-inflammatory, and 
      anti-apoptotic properties, promoting cell survival, histologically protecting 
      ovarian tissue, and ameliorating IR injury by reducing oxidative stress.
FAU - Arslan, Serkan
AU  - Arslan S
AD  - Department of Pediatric Surgery, Dicle University Medical School, 
      Diyarbakir-Turkiye.
FAU - Asir, Firat
AU  - Asir F
AD  - Department of Histology and Embryology, Dicle University Medical School, 
      Diyarbakir-Turkiye.
FAU - Ozkorkmaz, Ebru Gokalp
AU  - Ozkorkmaz EG
AD  - Department of Nursing, Yildirim Beyazit University Faculty of Health Sciences, 
      Ankara-Turkiye.
FAU - Azizoglu, Mustafa
AU  - Azizoglu M
AD  - Department of Pediatric Surgery, Dicle University Medical School, 
      Diyarbakir-Turkiye.
FAU - Basuguy, Erol
AU  - Basuguy E
AD  - Department of Pediatric Surgery, Dicle University Medical School, 
      Diyarbakir-Turkiye.
FAU - Okur, Mehmet Hanifi
AU  - Okur MH
AD  - Department of Pediatric Surgery, Dicle University Medical School, 
      Diyarbakir-Turkiye.
FAU - Ozcelik Otcu, Serap Mutlu
AU  - Ozcelik Otcu SM
AD  - Department of Gynecology and Obstetrics, Health Sciences University, Gynecology 
      and Obstetrics hospital, Diyarbakir-Turkiye.
FAU - Alagoz Karabel, Musemma
AU  - Alagoz Karabel M
AD  - Department of Pediatrics, Dicle University Medical School, Diyarbakir-Turkiye.
FAU - Kaplan, Ibrahim
AU  - Kaplan I
AD  - Department of Biochemistry Dicle University Medical School, Diyarbakir-Turkiye.
FAU - Aydogdu, Bahattin
AU  - Aydogdu B
AD  - Department of Pediatric Surgery, Balikesir University Medical School, 
      Balikesir-Turkiye.
LA  - eng
PT  - Journal Article
TT  - Over torsiyonu olan sicanlarda Passiflora incarnata'nin overin iskemi/reperfuzyon 
      hasari uzerinde koruyucu etkileri.
PL  - Turkey
TA  - Ulus Travma Acil Cerrahi Derg
JT  - Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency 
      surgery : TJTES
JID - 101274231
RN  - 0 (Antioxidants)
SB  - IM
MH  - Humans
MH  - Rats
MH  - Female
MH  - Animals
MH  - Antioxidants/pharmacology
MH  - Rats, Wistar
MH  - Ovarian Torsion
MH  - *Passiflora
MH  - Oxidative Stress
MH  - *Reperfusion Injury/drug therapy/prevention & control/pathology
MH  - Ischemia
PMC - PMC10767294
COIS- Conflict of Interest: None declared.
EDAT- 2023/12/11 06:45
MHDA- 2023/12/17 09:44
PMCR- 2023/12/11
CRDT- 2023/12/11 04:03
PHST- 2023/12/17 09:44 [medline]
PHST- 2023/12/11 06:45 [pubmed]
PHST- 2023/12/11 04:03 [entrez]
PHST- 2023/12/11 00:00 [pmc-release]
AID - TJTES-29-1344 [pii]
AID - 10.14744/tjtes.2023.52986 [doi]
PST - ppublish
SO  - Ulus Travma Acil Cerrahi Derg. 2023 Dec;29(12):1344-1350. doi: 
      10.14744/tjtes.2023.52986.