PMID- 38073770 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20231211 IS - 1792-1082 (Electronic) IS - 1792-1074 (Print) IS - 1792-1074 (Linking) VI - 27 IP - 1 DP - 2024 Jan TI - Renal cell carcinoma associated with Xp11.2 translocation/transcription factor E3 gene fusion: A case report and literature review. PG - 29 LID - 10.3892/ol.2023.14162 [doi] LID - 29 AB - Renal cell carcinoma (RCC) associated with Xp11.2 translocation/transcription factor E3 (TFE3) gene fusion is a rare subtype of RCC. A 31-year-old male patient was admitted to The Affiliated Hospital of Zunyi Medical University (Zunyi, China) with a solid mass in the left kidney during a routine health examination. After ruling out surgical contraindications, the patient underwent a laparoscopic left partial nephrectomy under general anesthesia. Postoperative pathology and fluorescence in situ hybridization (FISH) identified Xp11.2 translocation RCC. There was no tumor recurrence or metastasis during the 1-year follow-up. Xp11.2 translocation RCC is unusual, its clinical and imaging findings are not specific, and the diagnosis depends on TFE3-immunohistochemical assay and FISH analysis. Surgical resection is the first choice of treatment and its prognosis is worse than that of clear cell RCC, thus regular follow-ups are necessary. CI - Copyright: (c) Yang et al. FAU - Yang, Denghao AU - Yang D AD - Department of Urology, The Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563000, P.R. China. FAU - Tang, Wen AU - Tang W AD - Department of Urology, The Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563000, P.R. China. FAU - Liu, Mingwen AU - Liu M AD - Department of Urology, The Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563000, P.R. China. FAU - Xie, Zhifei AU - Xie Z AD - Department of Urology, The Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563000, P.R. China. FAU - Shi, Fei AU - Shi F AD - Department of Urology, People's Hospital of Honghuagang District, Zunyi, Guizhou 563000, P.R. China. FAU - Zhao, Zeju AU - Zhao Z AD - Department of Urology, The Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563000, P.R. China. FAU - Yang, Xiaorong AU - Yang X AD - Department of Pathology, The Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563000, P.R. China. FAU - Wu, Tao AU - Wu T AD - Department of Urology, The Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563000, P.R. China. LA - eng PT - Case Reports DEP - 20231121 PL - Greece TA - Oncol Lett JT - Oncology letters JID - 101531236 PMC - PMC10698840 OTO - NOTNLM OT - Xp11.2 OT - case report OT - fluorescence in situ hybridization OT - renal cell carcinoma OT - transcription factor E3 gene fusion COIS- The authors declare that they have no competing interests. EDAT- 2023/12/11 06:45 MHDA- 2023/12/11 06:46 PMCR- 2023/11/21 CRDT- 2023/12/11 05:35 PHST- 2023/08/30 00:00 [received] PHST- 2023/10/18 00:00 [accepted] PHST- 2023/12/11 06:46 [medline] PHST- 2023/12/11 06:45 [pubmed] PHST- 2023/12/11 05:35 [entrez] PHST- 2023/11/21 00:00 [pmc-release] AID - OL-27-1-14162 [pii] AID - 10.3892/ol.2023.14162 [doi] PST - epublish SO - Oncol Lett. 2023 Nov 21;27(1):29. doi: 10.3892/ol.2023.14162. eCollection 2024 Jan.