PMID- 38073888
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231211
IS  - 2772-431X (Electronic)
IS  - 2097-0684 (Print)
IS  - 2772-431X (Linking)
VI  - 2
IP  - 3
DP  - 2023 Sep
TI  - Genome tuning through HLA and KIR gene clusters impact susceptibility to dengue.
PG  - 167-177
LID - 10.1016/j.imj.2023.05.001 [doi]
AB  - Dengue is amongst the most prevalent viral diseases which globally affects 
      millions of individuals annually and renders billions at risk, particularly in 
      tropical and sub-tropical nations. WHO estimated 100-400 million infections each 
      year and reported 4.2 million active cases in 2019 worldwide. The infection is 
      caused by arthropod-transmitted dengue virus which is known to have 5 serotypes 
      (DENV1-5). Most of the cases show mild clinical symptoms; though others may 
      develop severe forms viz; dengue hemorrhagic fever and dengue shock syndrome. 
      Though limited literature suggests the population-specific genetic influence on 
      susceptibility and the clinical course of dengue; the genetic propensity of 
      dengue is largely unknown in most ethnicities. In this context, the human 
      leukocyte antigen (HLA) system represents the most polymorphic region of the 
      human genome and is crucial for the initiation of an appropriate immune response. 
      In most of the genome-wide association studies, the HLA complex is the most 
      significantly linked genetic region with susceptibility or protection towards 
      various infectious and noninfectious diseases. Killer immunoglobulin-like 
      receptors represent another highly variable system present on the surface of 
      natural killer (NK) cells which regulate the activity of NK cells through 
      interactions with their cognate HLA ligands. It is conceivable that the 
      interaction of HLA-Killer immunoglobulin-like receptors systems influences the 
      host susceptibility towards dengue infection as well the disease outcome. Here we 
      attempt to review these parameters in dengue infection and disease outcome. 
      Further detailed investigations are warranted towards the identification of novel 
      susceptibility markers and targeted therapeutic interventions.
CI  - (c) 2023 Published by Elsevier Ltd on behalf of Tsinghua University Press.
FAU - Sharma, Neha
AU  - Sharma N
AD  - Department of Biosciences, School of Basic and Applied Sciences, Galgotias 
      University, Greater Noida 203201, India.
FAU - Sharma, Gaurav
AU  - Sharma G
AD  - Department of Translational and Regenerative Medicine, Postgraduate Institute of 
      Medical Education and Research, Chandigarh 160012, India.
FAU - Kanga, Uma
AU  - Kanga U
AD  - Department of Transplant Immunology and Immunogenetics, All India Institute of 
      Medical Sciences, New Delhi 110029, India.
FAU - Toor, Devinder
AU  - Toor D
AD  - Amity University Uttar Pradesh, Amity Institute of Virology and Immunology, Amity 
      University, Noida 201301, India.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20230511
PL  - China
TA  - Infect Med (Beijing)
JT  - Infectious medicine
JID - 9918663679306676
PMC - PMC10699717
OTO - NOTNLM
OT  - DENV
OT  - Human leukocyte antigen
OT  - Killer immunoglobulin receptor
OT  - Pathogenesis and genetic susceptibility
EDAT- 2023/12/11 06:45
MHDA- 2023/12/11 06:46
PMCR- 2023/05/11
CRDT- 2023/12/11 05:37
PHST- 2022/11/08 00:00 [received]
PHST- 2023/05/05 00:00 [revised]
PHST- 2023/05/05 00:00 [accepted]
PHST- 2023/12/11 06:46 [medline]
PHST- 2023/12/11 06:45 [pubmed]
PHST- 2023/12/11 05:37 [entrez]
PHST- 2023/05/11 00:00 [pmc-release]
AID - S2772-431X(23)00028-X [pii]
AID - 10.1016/j.imj.2023.05.001 [doi]
PST - epublish
SO  - Infect Med (Beijing). 2023 May 11;2(3):167-177. doi: 10.1016/j.imj.2023.05.001. 
      eCollection 2023 Sep.