PMID- 38075030
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231211
IS  - 2391-5463 (Print)
IS  - 2391-5463 (Electronic)
VI  - 18
IP  - 1
DP  - 2023
TI  - miR-29 regulates metabolism by inhibiting JNK-1 expression in non-obese patients 
      with type 2 diabetes mellitus and NAFLD.
PG  - 20230873
LID - 10.1515/med-2023-0873 [doi]
LID - 20230873
AB  - Previous studies have shown that microRNAs (miRNAs) are involved in the 
      regulation of a variety of metabolic diseases, which related to some important 
      signal pathways. Our aim was to explore the possible mechanism of miRNAs by 
      revealing the differential expression of serum miRNAs in different BMI of type 2 
      diabetes mellitus (T2DM) patients with non-alcoholic fatty liver disease (NAFLD). 
      We found that miR-29 decreased liver aminotransferase gamma-GGT and uric acid 
      levels by inhibiting the expression of JNK-1 in non-obese T2DM patients with 
      NAFLD, and down-regulated the expression of atherosclerosis-related factor 
      lipoprotein phospholipase A2 (Lp-PLA2). Combined with bioinformatics analysis, we 
      speculate that this may be mediated by the AMPK signaling. These findings suggest 
      that miR-29 may be a potential targeted therapeutic strategy in T2DM patients 
      with NAFLD.
CI  - (c) 2023 the author(s), published by De Gruyter.
FAU - Lu, Fangdong
AU  - Lu F
AD  - Wuhan University of Science and Technology, Wuhan 430065, China.
FAU - Gong, Huaping
AU  - Gong H
AD  - Endocrinology Department, Hanchuan People's Hospital, Hanchuan 431600, China.
FAU - Duan, Linhai
AU  - Duan L
AD  - Endocrinology Department, Hanchuan People's Hospital, Hanchuan 431600, China.
FAU - Yan, Yuan
AU  - Yan Y
AD  - Endocrinology Department, Hanchuan People's Hospital, Hanchuan 431600, China.
FAU - Chen, Long
AU  - Chen L
AD  - Endocrinology Department, Hanchuan People's Hospital, Hanchuan 431600, China.
FAU - Peng, Pei
AU  - Peng P
AD  - Clinical Laboratory Department, Hanchuan People's Hospital, Hanchuan 431600, 
      China.
FAU - Zhang, Qiaoan
AU  - Zhang Q
AD  - Clinical Laboratory Department, Hanchuan People's Hospital, Hanchuan 431600, 
      China.
FAU - Song, Wenrong
AU  - Song W
AD  - Endocrinology Department, Hanchuan People's Hospital, No. 1 People's Avenue, 
      Hanchuan 431600, China.
FAU - Li, Jia
AU  - Li J
AD  - Endocrinology Department, Hanchuan People's Hospital, No. 1 People's Avenue, 
      Hanchuan 431600, China.
LA  - eng
PT  - Journal Article
DEP - 20231206
PL  - Poland
TA  - Open Med (Wars)
JT  - Open medicine (Warsaw, Poland)
JID - 101672167
PMC - PMC10710208
OTO - NOTNLM
OT  - AMPK signaling
OT  - JNK-1
OT  - NAFLD
OT  - diabetes mellitus
OT  - miR-29
COIS- Conflict of interest: All authors report no declarations of interest.
EDAT- 2023/12/11 06:45
MHDA- 2023/12/11 06:46
PMCR- 2023/12/06
CRDT- 2023/12/11 05:52
PHST- 2023/06/26 00:00 [received]
PHST- 2023/10/24 00:00 [revised]
PHST- 2023/11/17 00:00 [accepted]
PHST- 2023/12/11 06:46 [medline]
PHST- 2023/12/11 06:45 [pubmed]
PHST- 2023/12/11 05:52 [entrez]
PHST- 2023/12/06 00:00 [pmc-release]
AID - med-2023-0873 [pii]
AID - 10.1515/med-2023-0873 [doi]
PST - epublish
SO  - Open Med (Wars). 2023 Dec 6;18(1):20230873. doi: 10.1515/med-2023-0873. 
      eCollection 2023.