PMID- 38075069
OWN - NLM
STAT- MEDLINE
DCOM- 20231216
LR  - 20240301
IS  - 1664-2392 (Print)
IS  - 1664-2392 (Electronic)
IS  - 1664-2392 (Linking)
VI  - 14
DP  - 2023
TI  - Positive correlation between lipid accumulation product index and arterial 
      stiffness in Chinese patients with type 2 diabetes.
PG  - 1277162
LID - 10.3389/fendo.2023.1277162 [doi]
LID - 1277162
AB  - BACKGROUND: Many studies have confirmed that lipid accumulation products (LAP) 
      predict arterial stiffness (AS) in hypertensive patients. But there is little 
      research on the use of LAP in identifying early atherosclerosis in patients with 
      type 2 diabetes mellitus (T2DM). The aim of this study was to determine the 
      relationship between the LAP index and brachial-ankle pulse wave velocity (baPWV) 
      in Chinese patients with T2DM. METHODS: A total of 1471 Chinese participants with 
      T2DM, ranging in age from 18 to 80, were included in this cross-sectional study. 
      BaPWV measurements were used to calculate the AS. A baPWV greater than the 75th 
      percentile (1700 cm/s) was defined as indicating increased AS. The LAP index was 
      calculated from the combination of waist circumference (WC) and triglycerides 
      (TG). RESULTS: According to the quartiles of the LAP index, baPWV tended to 
      increase after adjusting for sex and age. Multiple linear regression analysis 
      showed that the beta coefficient (beta) of baPWV increased by 31.0 cm/s for each 
      unit of lnLAP that was increased, and the 95% confidence interval (CI) was (6.5, 
      55.5) cm/s. In multivariate logistic regression analyses, after fully adjusting 
      for confounders, the risk of elevated baPWV increased with each unit increase in 
      lnLAP, with an odds ratio (OR) of 1.3 (95% CI: 1.0, 1.8). According to the 
      generalized additive model (GAM), we found that lnLAP was positively correlated 
      with baPWV and baPWV elevation. The results were the same for males and females. 
      Subgroup analyses showed that the positive correlation between lnLAP and elevated 
      baPWV did not interact across all subgroups. CONCLUSIONS: In Chinese patients 
      with T2DM, LAP was strongly and positively correlated with baPWV and elevated 
      baPWV.
CI  - Copyright (c) 2023 Mao, Gan, Zhou, Yu, Zhou, Lu, Jin, Liu and Deng.
FAU - Mao, Jing
AU  - Mao J
AD  - Department of Medicine, University of South China, Hengyang, Hunan, China.
FAU - Gan, Shenglian
AU  - Gan S
AD  - Department of Endocrinology, Changde Hospital, Xiangya School of Medicine, 
      Central South University, Changde, China.
FAU - Zhou, Quan
AU  - Zhou Q
AD  - Department of Science and Education, Changde Hospital, Xiangya School of 
      Medicine, Central South University, Changde, China.
FAU - Yu, Fang
AU  - Yu F
AD  - Department of Endocrinology, Changde Hospital, Xiangya School of Medicine, 
      Central South University, Changde, China.
FAU - Zhou, Haifeng
AU  - Zhou H
AD  - Department of Endocrinology, Changde Hospital, Xiangya School of Medicine, 
      Central South University, Changde, China.
FAU - Lu, Huilin
AU  - Lu H
AD  - Department of Endocrinology, Changde Hospital, Xiangya School of Medicine, 
      Central South University, Changde, China.
FAU - Jin, Jing
AU  - Jin J
AD  - Department of Endocrinology, Changde Hospital, Xiangya School of Medicine, 
      Central South University, Changde, China.
FAU - Liu, Qin
AU  - Liu Q
AD  - Department of Endocrinology, Changde Hospital, Xiangya School of Medicine, 
      Central South University, Changde, China.
FAU - Deng, Zhiming
AU  - Deng Z
AD  - Department of Endocrinology, Changde Hospital, Xiangya School of Medicine, 
      Central South University, Changde, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20231123
PL  - Switzerland
TA  - Front Endocrinol (Lausanne)
JT  - Frontiers in endocrinology
JID - 101555782
SB  - IM
MH  - Male
MH  - Female
MH  - Humans
MH  - *Diabetes Mellitus, Type 2
MH  - Ankle Brachial Index
MH  - Risk Factors
MH  - *Lipid Accumulation Product
MH  - *Vascular Stiffness
MH  - Cross-Sectional Studies
MH  - Pulse Wave Analysis
MH  - China/epidemiology
PMC - PMC10702222
OTO - NOTNLM
OT  - arterial stiffness
OT  - brachial-ankle pulse wave velocity
OT  - insulin resistance
OT  - lipid accumulation product
OT  - type 2 diabetes mellitus
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2023/12/11 06:45
MHDA- 2023/12/17 09:42
PMCR- 2023/01/01
CRDT- 2023/12/11 05:52
PHST- 2023/08/14 00:00 [received]
PHST- 2023/11/06 00:00 [accepted]
PHST- 2023/12/17 09:42 [medline]
PHST- 2023/12/11 06:45 [pubmed]
PHST- 2023/12/11 05:52 [entrez]
PHST- 2023/01/01 00:00 [pmc-release]
AID - 10.3389/fendo.2023.1277162 [doi]
PST - epublish
SO  - Front Endocrinol (Lausanne). 2023 Nov 23;14:1277162. doi: 
      10.3389/fendo.2023.1277162. eCollection 2023.