PMID- 38075228
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231211
IS  - 2296-861X (Print)
IS  - 2296-861X (Electronic)
IS  - 2296-861X (Linking)
VI  - 10
DP  - 2023
TI  - Monounsaturated and polyunsaturated fatty acids concerning prediabetes and type 2 
      diabetes mellitus risk among participants in the National Health and Nutrition 
      Examination Surveys (NHANES) from 2005 to March 2020.
PG  - 1284800
LID - 10.3389/fnut.2023.1284800 [doi]
LID - 1284800
AB  - OBJECTIVE: Unsaturated fatty acids (UFA) may be related to glycometabolism. While 
      associations between UFA intake (especially their subtype) and prediabetes or 
      type 2 diabetes mellitus (T2DM) need to be further studied. In this study, we 
      aimed to evaluate the potential relation of UFA with prediabetes and T2DM. 
      METHODS: A total of 16,290 adults aged older than 18 years from the National 
      Health and Nutrition Examination Survey (NHANES) from 2005 to March 2020 were 
      included in the present analysis. Dietary intake was assessed by two day, 24-hour 
      dietary recalls and daily intake of total monounsaturated fatty acids (MUFA) and 
      polyunsaturated fatty acids (PUFA); four specific fatty acids of MUFA and seven 
      specific fatty acids of PUFA were calculated. Prediabetes and T2DM were diagnosed 
      by fasting glucose, glycohemoglobin, and self-reported medication or insulin. 
      Rao-Scott modified chi-square tests, the Taylor series linearization method, and 
      multivariable logistic regression analyses were applied to analyze the 
      associations of dietary MUFA and PUFA intake with diabetes risk. RESULTS: Of the 
      participants, 44.34% had prediabetes and 13.16% had T2DM patients. From 
      multivariate analysis, we found that intake of MUFA, PUFA, and some subtypes was 
      negatively associated with the risk of prediabetes and T2DM in Americans. 
      Compared with adults in the lowest tertile, those in the highest MUFA (PUFA) 
      tertile had an approximately 50% (49%) and 69% (68%) lower risk of prediabetes 
      and T2DM, respectively. Moreover, the effects of the subtypes of MUFA and PUFA on 
      prediabetes and T2DM were different. Higher intakes of MFA 18:1, MFA 20:1, PFA 
      18:2, and PFA 18:3 and higher tertile intakes of MFA 16:1 and PFA 20:4 were 
      related to a lower risk of prediabetes and T2DM. Similarly, the effects of MUFA, 
      PUFA, and subtype on prediabetes and T2DM varied among different age groups, 
      being weakened along with age. CONCLUSION: Our study suggested that total MUFA 
      and PUFA intake might be essential in preventing prediabetes and T2DM, especially 
      in Americans. However, this protective effect may decrease with age. Moreover, 
      the effects of the specific UFA on prediabetes and T2DM need further 
      consideration.
CI  - Copyright (c) 2023 Jiang, Yang, Li, Feng, Miao, Shi and Xue.
FAU - Jiang, Susu
AU  - Jiang S
AD  - Department of Child and Adolescent Health, School of Public Health, Guangdong 
      Pharmaceutical University, Guangzhou, Guangdong, China.
FAU - Yang, Wenhan
AU  - Yang W
AD  - Department of Child and Adolescent Health, School of Public Health, Guangdong 
      Pharmaceutical University, Guangzhou, Guangdong, China.
FAU - Li, Yanmei
AU  - Li Y
AD  - Department of Child and Adolescent Health, School of Public Health, Guangdong 
      Pharmaceutical University, Guangzhou, Guangdong, China.
FAU - Feng, Jingying
AU  - Feng J
AD  - Food Science School, Guangdong Pharmaceutical University, Zhongshan, Guangdong, 
      China.
FAU - Miao, Junjie
AU  - Miao J
AD  - School of Public Health, Hebei Medical University, Shijiazhuang, Hebei, China.
FAU - Shi, Hongmei
AU  - Shi H
AD  - School of Public Health, Hebei Medical University, Shijiazhuang, Hebei, China.
FAU - Xue, Hongmei
AU  - Xue H
AD  - The First Hospital of Hebei Medical University, Shijiahzunag, Hebei, China.
AD  - College of Public Health, Hebei University, Baoding, Hebei, China.
LA  - eng
PT  - Journal Article
DEP - 20231124
PL  - Switzerland
TA  - Front Nutr
JT  - Frontiers in nutrition
JID - 101642264
PMC - PMC10704138
OTO - NOTNLM
OT  - NHANES
OT  - monounsaturated fatty acids
OT  - polyunsaturated fatty acid
OT  - prediabetes
OT  - type 2 diabetes
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2023/12/11 06:45
MHDA- 2023/12/11 06:46
PMCR- 2023/01/01
CRDT- 2023/12/11 05:54
PHST- 2023/08/29 00:00 [received]
PHST- 2023/10/30 00:00 [accepted]
PHST- 2023/12/11 06:46 [medline]
PHST- 2023/12/11 06:45 [pubmed]
PHST- 2023/12/11 05:54 [entrez]
PHST- 2023/01/01 00:00 [pmc-release]
AID - 10.3389/fnut.2023.1284800 [doi]
PST - epublish
SO  - Front Nutr. 2023 Nov 24;10:1284800. doi: 10.3389/fnut.2023.1284800. eCollection 
      2023.