PMID- 38075398
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231211
IS  - 2001-0370 (Print)
IS  - 2001-0370 (Electronic)
IS  - 2001-0370 (Linking)
VI  - 23
DP  - 2024 Dec
TI  - The influence of Helicobacter pylori, proton pump inhibitor, and obesity on the 
      gastric microbiome in relation to gastric cancer development.
PG  - 186-198
LID - 10.1016/j.csbj.2023.11.053 [doi]
AB  - Helicobacter pylori infection is still the main risk factor for the development 
      of gastric cancer (GC). We explore the scientific evidence for the role of the 
      gastric microbiome beyond Helicobacter pylori (H. pylori) in gastric 
      carcinogenesis. The composition of the gastric microbiome in healthy individuals, 
      in presence and absence of H. pylori infection, in proton pump inhibitor 
      (PPI)-users, obese individuals, and GC patients was investigated. Possible 
      mechanisms for microbial involvement, limitations of available research and 
      options for future studies are provided. A common finding amongst studies was 
      increased levels of Streptococcus, Prevotella, Neisseria, and Actinomyces in 
      healthy individuals or those with H. pylori-negative gastritis. In PPI-users the 
      risk for GC increases with the treatment duration, and the gastric microbiome 
      shifts, with the most consistent increase in the genus Streptococcus. Similarly, 
      in obese individuals, Streptococcus was the most abundant genus, with an 
      increased risk for cardia GC. The genera Streptococcus, Lactobacillus and 
      Prevotella were found to be more prominent in GC patients in multiple studies. 
      Potential mechanisms of non-H. pylori microbiota contributing to GC are linked to 
      lipopolysaccharide production, contribution to inflammatory pathways, and the 
      formation of N-nitroso compounds and reactive oxygen species. In conclusion, the 
      knowledge of the gastric microbiome in GC is mainly descriptive and based on 
      sequencing of gastric mucosal samples. For a better mechanistic understanding of 
      microbes in GC development, longitudinal cohorts including precancerous lesions, 
      different regions in the stomach, and subtypes of GC, and gastric organoid models 
      for diffuse and intestinal type GC should be employed.
CI  - (c) 2023 The Authors.
FAU - Zhou, Chengliang
AU  - Zhou C
AD  - Radboud University Medical Center, Radboud Institute for Molecular Life Sciences, 
      Department of Pathology, P.O. box 9101, 6500 HB Nijmegen, the Netherlands.
FAU - Bisseling, Tanya M
AU  - Bisseling TM
AD  - Radboud University Medical Center, Radboud Institute for Molecular Life Sciences, 
      Department of Gastroenterology and Hepatology, P.O. box 9101, 6500 HB Nijmegen, 
      the Netherlands.
FAU - van der Post, Rachel S
AU  - van der Post RS
AD  - Radboud University Medical Center, Radboud Institute for Molecular Life Sciences, 
      Department of Pathology, P.O. box 9101, 6500 HB Nijmegen, the Netherlands.
FAU - Boleij, Annemarie
AU  - Boleij A
AD  - Radboud University Medical Center, Radboud Institute for Molecular Life Sciences, 
      Department of Pathology, P.O. box 9101, 6500 HB Nijmegen, the Netherlands.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20231130
PL  - Netherlands
TA  - Comput Struct Biotechnol J
JT  - Computational and structural biotechnology journal
JID - 101585369
PMC - PMC10704269
OTO - NOTNLM
OT  - 16 s rRNA sequencing
OT  - Gastric microbiome
OT  - Non-Helicobacter pylori bacteria
OT  - Obesity
OT  - PPI use
COIS- The authors declare the following financial interests/personal relationships 
      which may be considered as potential competing interests: Cheng-Liang Zhou 
      reports financial support was provided by CSC.
EDAT- 2023/12/11 06:45
MHDA- 2023/12/11 06:46
PMCR- 2023/11/30
CRDT- 2023/12/11 05:56
PHST- 2023/07/13 00:00 [received]
PHST- 2023/11/27 00:00 [revised]
PHST- 2023/11/27 00:00 [accepted]
PHST- 2023/12/11 06:46 [medline]
PHST- 2023/12/11 06:45 [pubmed]
PHST- 2023/12/11 05:56 [entrez]
PHST- 2023/11/30 00:00 [pmc-release]
AID - S2001-0370(23)00469-5 [pii]
AID - 10.1016/j.csbj.2023.11.053 [doi]
PST - epublish
SO  - Comput Struct Biotechnol J. 2023 Nov 30;23:186-198. doi: 
      10.1016/j.csbj.2023.11.053. eCollection 2024 Dec.