PMID- 38075420
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231211
IS  - 2532-8689 (Electronic)
IS  - 1124-9390 (Print)
IS  - 1124-9390 (Linking)
VI  - 31
IP  - 4
DP  - 2023
TI  - Interaction of the viral infectious agents in the development and exacerbation of 
      the multiple sclerosis.
PG  - 476-487
LID - 10.53854/liim-3104-6 [doi]
AB  - Multiple sclerosis (MS) is a chronic inflammatory demyelinating disorder of the 
      central nervous system (CNS). The underlying cause of MS is still unknown. 
      Multiple risk factors have been suggested that involve a combination of genetic, 
      environmental, and infectious factors that contribute along with a weakened 
      immune system. There is growing evidence supporting the potential role of viral 
      infections in the development of the disease. Viruses like human immunodeficiency 
      virus (HIV), John Cunningham virus (JCV), Varicella-Zoster virus (VZV), human 
      herpesvirus 6 (HHV-6), Epstein-Barr virus (EBV), and human endogenous 
      retroviruses (HERVs) have been proposed in the pathogenesis of MS. Their 
      pathogenetic mechanisms are not well known, but several possibilities have been 
      discussed. The present study highlights the proposed potential molecular and 
      genetic mechanisms underlying this viral interaction and its implications for the 
      development of MS.
FAU - Mahdavi, Sina
AU  - Mahdavi S
AD  - Department of Microbiology and Virology, Tabriz University of Medical Sciences, 
      Tabriz, Iran.
FAU - Ozma, Mahdi Asghari
AU  - Ozma MA
AD  - Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, 
      Iran.
FAU - Azadi, Arezou
AU  - Azadi A
AD  - Department of Microbiology and Virology, Tabriz University of Medical Sciences, 
      Tabriz, Iran.
FAU - Sadeghi, Javid
AU  - Sadeghi J
AD  - Department of Microbiology and Virology, Tabriz University of Medical Sciences, 
      Tabriz, Iran.
FAU - Bannazadeh Baghi, Hossein
AU  - Bannazadeh Baghi H
AD  - Infectious and Tropical Diseases Research Center, Tabriz University of Medical 
      Sciences, Tabriz, Iran.
FAU - Ahangar Oskouee, Mahin
AU  - Ahangar Oskouee M
AD  - Infectious and Tropical Diseases Research Center, Tabriz University of Medical 
      Sciences, Tabriz, Iran.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20231201
PL  - Italy
TA  - Infez Med
JT  - Le infezioni in medicina
JID - 9613961
PMC - PMC10705862
OTO - NOTNLM
OT  - Epstein-Barr Virus
OT  - Human Endogenous Retrovirus
OT  - Human Immunodeficiency Virus
OT  - John Cunningham Virus
OT  - Multiple Sclerosis
COIS- Conflict of interest: None.
EDAT- 2023/12/11 06:45
MHDA- 2023/12/11 06:46
PMCR- 2023/12/01
CRDT- 2023/12/11 05:56
PHST- 2023/08/08 00:00 [received]
PHST- 2023/10/28 00:00 [accepted]
PHST- 2023/12/11 06:46 [medline]
PHST- 2023/12/11 06:45 [pubmed]
PHST- 2023/12/11 05:56 [entrez]
PHST- 2023/12/01 00:00 [pmc-release]
AID - 1124-9390_31_4_2023_476-487 [pii]
AID - 10.53854/liim-3104-6 [doi]
PST - epublish
SO  - Infez Med. 2023 Dec 1;31(4):476-487. doi: 10.53854/liim-3104-6. eCollection 2023.